Adenosine yog dab tsi?

Adenosine yog ib qho nucleoside uas tshwm sim hauv txhua lub hlwb ntawm lub cev. Chemically nws yog 6-amino-9-beta-D-ribofuranosyl-9-H-purine.

Cov qauv thiab cov ntshav

Adenosine yog tsim los ntawm adenine txuas rau ribose qab zib molecule (ribofuranose) moiety. Daim ntawv cog lus uas txuas cov adenine thiab ribose qab zib yog hu ua β-N9-glycosidic daim ntawv cog lus.

Cov qib plasma adenosine ib txwm nyob nruab nrab ntawm 0.04 thiab 0.2 micromoles.

Physiological thiab pharmacological lub luag haujlwm ntawm Adenosine

Hauv lub cev, adenosine pab hloov lub zog ntawm tes los ntawm kev tsim cov molecules xws li adenosine triphosphate (ATP) thiab adenosine diphosphate (ADP).

Adenosine kuj tseem ua lub luag haujlwm hauv kev taw qhia ntau txoj hauv kev thiab kev ua haujlwm hauv lub cev los ntawm kev tsim cov khoom lag luam zoo li cyclic adenosine monophosphate (cAMP).

Adenosine nyob rau hauv lub hlwb

Nyob rau hauv lub hlwb adenosine yog ib qho inhibitory neurotransmitter. Qhov no txhais tau tias, adenosine tuaj yeem ua raws li lub hauv paus paj hlwb kev nyuaj siab. Nyob rau hauv tej yam kev mob, nws txhawb kev pw tsaug zog thiab suppresses arousal. Thaum tsaug zog, qib ntawm adenosine hauv lub hlwb nce txhua teev.

Adenosine hauv plawv

Nyob rau hauv lub plawv adenosine ua rau dilation ntawm cov hlab ntsha coronary uas txhim kho cov ntshav mus rau lub plawv. Adenosine kuj nce txoj kab uas hla ntawm cov hlab ntsha hauv cov kab mob peripheral.

Hauv plawv adenosine txo qis lub plawv dhia thiab hauv cov ntshav nws muaj kev tiv thaiv platelet. Antiplatelet kev ua haujlwm tiv thaiv platelet aggregation thiab coagulation.

Adenosine hauv cov ntshav

Hauv cov ntshav adenosine yog tawg los ntawm adenosine deaminase. Cov enzyme no muaj nyob rau hauv cov hlwb liab thiab cov hlab ntsha. Cov tshuaj Dipyridamole yog ib qho inhibitor ntawm enzyme adenosine deaminase thiab yog li nce qib ntawm adenosine hauv cov ntshav. Qhov no ua rau cov hlab ntsha dilatation thiab txhim kho cov ntshav ntws los ntawm cov hlab ntsha coronary uas muab cov leeg plawv.

Adenosine nyob rau hauv lub raum, ntsws thiab lub siab

Nyob rau hauv ob lub raum adenosine txo qis raum cov ntshav khiav thiab txo qhov tsim ntawm renin los ntawm ob lub raum.

Nyob rau hauv lub ntsws nws ua rau constriction ntawm cov hlab ntsha thiab nyob rau hauv lub siab nws ua rau constriction ntawm cov hlab ntsha thiab ua rau kom glycogen stagnation ntawm cov piam thaj.

Adenosine yog ib qho tshwm sim ib txwm muaj uas ua lub luag haujlwm tseem ceeb hauv ntau yam txheej txheem physiological hauv tib neeg lub cev. Nws yog ib tug nucleoside, uas txhais tau hais tias nws yog tsim los ntawm ib tug adenine molecule txuas mus rau ib tug ribose molecule. Adenosine muaj nyob hauv txhua lub hlwb thiab koom nrog hauv kev hloov pauv hluav taws xob ua ib feem ntawm adenosine triphosphate (ATP), lub xov tooj ntawm lub zog tseem ceeb. Ntxiv nrog rau nws lub luag haujlwm hauv lub zog metabolism, adenosine kuj tseem ua lub cim qhia molecule, ua los ntawm cov receptors tshwj xeeb hauv lub cev.

Ib qho tseem ceeb ntawm adenosine pharmacology yog nws cov txheej txheem ntawm kev ua. Adenosine ua haujlwm los ntawm kev khi rau ib qho adenosine receptors, ntawm uas muaj plaub yam subtypes: A1, A2A, A2B, thiab A3. Txhua isoform yog txuam nrog kev sib txawv physiological functions thiab taw qhia txoj kev. Thaum adenosine khi rau nws cov receptors, nws tswj ntau yam txheej txheem ntawm tes, suav nrog kev xa cov paj hlwb, lub suab nrov, thiab kev tiv thaiv kab mob. Piv txwv li, kev ua kom cov A1 receptors tuaj yeem ua rau inhibition ntawm neurotransmitter tso tawm, thaum ua kom cov A2A receptors tuaj yeem ua rau vasodilation thiab tiv thaiv cov teebmeem.

Nkag siab txog cov tshuaj pharmacology ntawm adenosine ua rau kev siv tshuaj kho mob hauv ntau qhov chaw kho mob. Ib qho ntawm cov kws kho mob paub zoo tshaj plaws ntawm kev siv adenosine yog nws lub luag haujlwm hauv kev kho mob ntawm qee yam mob plawv arrhythmias. Adenosine yog siv los ua tus neeg sawv cev antiarrhythmic vim tias nws muaj peev xwm ua kom qis qis los ntawm atrioventricular node, yog li cuam tshuam txoj hauv kev rov qab los thiab rov ua kom lub cev zoo li qub. Tsis tas li ntawd, adenosine yog siv los ua tus kws kho mob kev ntxhov siab hauv kev tshawb fawb txog kev mob plawv los soj ntsuam myocardial perfusion.

Nyob rau hauv cov ntsiab lus, adenosine yog ib tug multifaceted molecule nrog ntau yam kev kho mob siv vim nws pharmacological zog thiab mechanism ntawm kev txiav txim. Nws lub peev xwm los hloov cov txheej txheem ntawm tes los ntawm kev sib cuam tshuam receptor tshwj xeeb ua rau nws yog ib qho cuab yeej tseem ceeb hauv kev kho ntau yam mob, los ntawm lub plawv arrhythmias mus rau cov kab mob ua pa nrog rau cov ntawv thov kev tiv thaiv neuroprotective. Raws li kev tshawb fawb ntawm adenosine txuas ntxiv mus, kev siv tshuaj kho mob tshiab rau cov molecule ntxim nyiam no tseem tuaj yeem tshwm sim, ntxiv nthuav nws cov peev xwm kho mob hauv tshuaj.

Pls ua siab zoo hu rau Alisa kom paub meej ntxiv ntawmsales02@imaherb.com