nicotinamide yog dab tsi?

nicotinamide yog dab tsi?

Nicotinamide, tseem hu ua niacinamide los yog nicotinic acid amide, yog cov dej-soluble, active daim ntawv ntawm vitamin B3. Nws tau raug nce mus kawm rau ntau qhov sib txawv indications nyob rau hauv lub teb ntawmdermatology, tab sis xav tau kev tshawb fawb ntxiv kom paub meej nws tus nqi.

Nicotinamide yog ib txwm muaj nyob rau hauv me me nyob rau hauv poov xab, lean nqaij, ntses, txiv ntseej thiab legumes. Nws kuj feem ntau ntxiv rau cov nplej thiab lwm yam khoom noj. Qhov ncauj nicotinamide muaj li 20-30 mg hauv multivitamin ua ke, thiab ntawm nws tus kheej li pheej yig 500-mg ntsiav tshuaj. Nws kuj tau muab tso rau hauv ntau yamtshuajcov tshuaj xws li tshuaj pleev thaiv hnub thiab tshuaj pleev ib ce.

nicotinamide ua haujlwm li cas?

Cov teebmeem dav dav ntawm nicotinamide tuaj yeem piav qhia los ntawm nws lub luag haujlwm xws li:

• Acellularlub zog precursor
• Ib tug modulator ntawmmob cytokines
• Ibinhibitorntawmnuclear enzymepoly (adenosine diphosphate-ribose [ADP]) polymerase [PARP], uas ua lub luag haujlwm tseem ceeb hauvDNAkho, txij nkawm ntawm genomic stability, thiab cellular teb rau kev raug mob nrog raumobthiabapoptosis(cell tuag).

nicotinamide siv rau dab tsi?

Vitamin B3 yog qhov tseem ceeb rau kev noj qab haus huv; tsis muaj peev xwm ua rau muaj mob hnyav, pellagra. Qhov ncauj nicotinamide tuaj yeem siv tau zoo los kho pellagra.

Nicotinamide siv los ua tshuaj yuav pab tau rau ntawm daim tawv nqaij ntawm ntau txoj kev.

• Nicotinamide muajanti-inflammatorycov khoom, uas yuav siv tau rau kev kho mob ntawm bullous (blistering) kab mob.
• Nws tuaj yeem txhim kho pob txuv los ntawm nws cov tshuaj tiv thaiv kab mob thiab txo sebum.
• Nws tuaj yeem txhim kho daim tawv nqaij barrier ua haujlwm los ntawm kev txo cov dej los ntawm qhovepidermis(cov txheej txheem ntawm daim tawv nqaij) yog li ua rau daim tawv nqaij hydration.
• Nws yog qhia los txhim kho complexion, los ntawm kev txhim kho covpigmentation, blotchiness thiab redness ntawm daim tawv nqaij laus; nws yog siv nyob rau hauv ib cotshuaj pleev ib cecov khoom.
• Nws tuaj yeem txo cov actinic keratoses thiab kev pheej hmoo ntawm cov qog nqaij hlav ntawm daim tawv nqaij, tshwj xeeb tshaj yog squamous cell carcinoma.
• Nws tau raug siv los kho polymorphic lub teeb tawg.

Cov tawv nqaij mob kho nrog nicotinamide

• Qhov ncauj nicotinamide

Bullous pemphigoid

Kev sib xyaw ntawm qhov ncauj nicotinamide thiab tetracycline zoo li yog ib qho txiaj ntsig zoo raukab kesteroids nyob rau hauv kev kho mob ntawm bullous pemphigoid. Nws yog tsawgtshuaj lomthiab muaj kev nyab xeeb dua li dapsone thiab prednisone.

Nyob rau hauv tsawg kawg yog ib qho qhib-labeled soj ntsuam kev sib piv ntawm kev sib xyaw ntawm 500 mg ntawm nicotinamide, peb zaug ib hnub twg, thiab 500 mg ntawm tetracycline plaub zaug ib hnub twg, nrog prednisone, nyob rau hauv 20 cov neeg mob nrog bullous pemphigoid, muaj tsib cov lus teb thiab tsib feem lus teb. , hauv pawg nicotinamide thiab tetracycline piv nrog ib qho lus teb ua tiav thiab tsib cov lus teb ib nrab hauv pawg prednisone, tom qab 8 lub lis piam ntawm kev kho mob. Tag nrho tsib cov neeg mob ua tiav cov lus teb hauv pawg nicotinamide thiab tetracycline tseem tsis muaj kab mob nyob rau lub sijhawm noj tshuaj ntau dua 10 lub hlis tom qab, thaum peb tus neeg mob hauv pab pawg prednisone tau rov ua tus kab mob flare-ups nrog steroid tapering nyob rau tib lub sijhawm.

tawv nqaij mob cancer

Cov tshuaj placebo-Cov kev sim tswj tau qhia tias muaj kev pheej hmoo siab rau cov neeg mob hnub ci puas tsuaj noj qhov ncauj nicotinamide uas muaj cov actinic keratoses thiab cutaneous squamous cell carcinomas tuaj yeem xav tias yuav txo qis ntawm cov neeg tshiab.kab mobdhau sijhawm. Cov pov thawj tsis meej.

Cov teebmeem ntawm qhov ncauj nicotinamide

Qhov ncauj nicotinamide feem ntau ua tau zoo nyob rau hauv koob tshuaj qis dua 3 g / hnub. Nws tsis ua rau mob plab lossis plab hnyuv, tsis zoo li nws cov nicotinic acid ua ntej. Nws tau raug tshaj tawm tias ua kom tawm hws, nce ntshav qab zib, thiab ua rauhypotension.

Kev noj tshuaj ntau ntau ntawm nicotinamide tuaj yeem ua rau xeev siab.

• Cov tshuaj nicotinamide

Pob txuv Nicotinamide, muaj nyob rau hauv tshuaj pleev ib cecream,gelthiab cov ntaub ntawv ntawm qhov ncauj (xws li Nicomide®), tau pom tias muaj txiaj ntsig zoo hauv kev tshem pob txuv. Hauv kev sim tshuaj ntsuam xyuas, 4% nicotinamide gel tau pom tias muaj txiaj ntsig zoo li cov tshuaj tua kab mob 1% clindamycin gel hauv kev kho pob txuv vulgaris hauv 76 cov neeg mob uas muaj pob txuv nruab nrab. Txoj kev tshawb no xaus lus tias cov tshuaj tiv thaiv kab mob ntawm nicotinamide tuaj yeem ua rau nws txoj kev vam meej hauv pob txuv. Nicotinamide kuj txo cov qog sebum ntau lawm.Sebyog lub luag hauj lwm rau lub ntsej muag ci thiab pab txhawb rau noninflamed comedones thiab inflammatory pob txuv lesions. Cov txiaj ntsig ntawm kev soj ntsuam zoo hauv cov poj niam Caucasian thiab Nyij Pooj tau pom tias daim ntawv thov ntawm 2% nicotinamide moisturizer rau lub ntsej muag rau 4-6 lub lis piam txo sebum ntau lawm nrog qhov sib txawv ntawm lub ntsej muag ci thiab oiliness.

Nicotinamide gel yog muag raws li ib qhodhau ntawm lub txeekho pob txuv hauv Canada, Australia, NZ, UK, USA thiab Ireland. Yog tias daim ntawv thov ob zaug ib hnub ua rau cov tawv nqaij qhuav heev, ib qho yuav txo tau ib zaug ib hnub, lossis txhua hnub.

Rosacea

Cov tsos mob thiab cov tsos mob ntawm rosacea muaj xws li ua rau lub ntsej muag qhuav qhuav, liab thiab rhiab heev. Nyob rau hauv tsawg kawg yog ob txoj kev tshawb fawb, moisturizers uas muaj nicotinamide tau pom tias yuav txhim kho daim tawv nqaij barrier muaj nuj nqi nyob rau hauv cov neeg mob rosacea, ua rau txo qis cov tshuaj tiv thaiv.irritantssuav nrog tshuaj ntxuav tes thiab tshuaj pleev ib ce.

Nicotinamide ua haujlwm ua ntej ntawm nicotinamide adenine dinucleotide (NAD) thiab nicotinamide adenine dinucleotide phosphate (NADP), uas yog co-cov enzymes(facilitators ntawmenzymaticcov tshuaj tiv thaiv) tseem ceeb rau ntau txoj hauv kev metabolic. Cov co-enzymes no ua lub luag haujlwm hauv lub cevmetabolismntawmqabzib, cellular zog ntau lawm, thiabsynthesisntawmlipids.Cov theem ntawm NADH / NADPH (cov ntawv txo qis ntawm NAD thiab NADP) txo qis nrog lub hnub nyoog thiab cov tshuaj pleev xim nicotinamide zoo li thim rov qab. Hauv ntau cov kev tshawb fawb soj ntsuam, tshuaj pleev xim nicotinamide txhim kho cov kab zoo thiab wrinkles, hyperpigmented me ntsis, liab blotchiness, thiab daim tawv nqaij salllowness (daj) thiab elasticity. Ib txoj kev tshawb fawb pom tias nicotinamide ua kom cov tawv nqaij ntau lawmceramides, uas yog ntuj emollients thiab tiv thaiv daim tawv nqaij, yog li txhim kho daim tawv nqaij hydration.

Aob-dig muag, placebo-tswj, cais-ntsej muag, sab laug-txoj cai,randomizedKev kawm 12-lub lim tiam hauv 50 tus poj niam tau soj ntsuam cov teebmeem ntawm 5% tshuaj pleev nicotinamide ntawm ntau yam cim ntawm daim tawv nqaij laus. Cov kws tshawb fawb tau tshaj tawm cov tshuaj pleev xim nicotinamide ua rau muaj kev txhim kho tseem ceeb hauv cov kab zoo / wrinkles, pigmentation, kev ntxhib los mos thiab liab blotchiness. Txoj kev tshawb no tau txhawb nqa los ntawm Proctor thiab Gamble.

Lwm txoj kev tshawb fawb ntawm 30 tus poj niam noj qab haus huv Nyij Pooj tau tshaj tawm txog kev txhim kho ntawm daim tawv muag wrinkles tom qab yim lub lis piam ntawm kev siv cov tshuaj pleev ib ce uas muaj 4% nicotinamide.

Nicotinamide tau txais txiaj ntsig zoo thiab feem ntau tuaj yeem siv los ntawm cov neeg uas tsis tuaj yeem zam cov tshuaj pleev xim retinoids lossis txiv hmab txiv ntoo acids.

Cov teebmeem Anticancer

Ultraviolet hluav taws xob (UVR) yog qhov tseem ceeb ntawm kev pheej hmoo rau mob qog noj ntshavkev loj hlob.Cov mechanisms uas UVR ua raumob qog noj ntshavyog complex nrog rau kev puas tsuaj ncaj qha rau DNA thiab cuam tshuam rau lub cev tiv thaiv kab mob. Nicotinamide tau pom tias yuav txhim khu kev kho ntawm ncaj qha thiab oxidative DNA puas tsuaj rau tib neegkeratinocytesthiab tib neeg daim tawv nqaij. Nws muaj peev xwm tiv thaiv tauUV-inducedtiv thaiv kab mob, pom nyob rau hauv kev tshawb fawb ntawm cov neeg tuaj yeem pab dawb nrog kev kuaj Mantoux zoo (zoo tuberculin rhiab heev kuaj). Cov tshuaj tiv thaiv Mantoux tuaj yeem cuam tshuam los ntawm kev raug UVR. Nicotinamide txo qhov kev tiv thaiv kab mob no thaum nws tau siv ua ntej lossis tom qab raug UVR (simulating tshav ntuj raug).

Hauv kev sim tshuaj ntsuam xyuas randomized hauv 50 tus neeg mob, 1% nicotinamide gel tau siv ob zaug ib hnub rau lub taub hau, hauv pliaj thiab txhais tes rau rau lub hlis txo qis.txhais tau tiastus lej ntawmprecancerousactinic keratoses los ntawm 28%.

Nicotinamide tsis ua haujlwm li tshuaj pleev thaiv hnub (thiab tsis tiv thaiv tshav ntuj). Nws tsis muaj cov khoom antioxidant, tab sis nws tuaj yeem cuam tshuam rau kev ua kom muaj zog ntxiv, cell zog metabolism, thiab apoptosis (cell tuag).

Cov ntaub ntawv pom zoo yog cov ntaub ntawv tseem ceeb ntawm cov tshuaj, suav nrog kev pom zoo siv, koob tshuaj, thiab cov ntaub ntawv kev nyab xeeb. Tshawb xyuas daim ntawv teev cov ntaub ntawv tus kheej hauv koj lub tebchaws kom paub txog cov tshuaj.