Waa maxay PROCYANIDIN B-2 (laga soo saaray tufaaxa)?

Waa maxay taasi?

Procyanidin B-2, waa fasal hoose oo flavonoids ah oo loo yaqaan inay sameeyaan antioxidant awood leh, daaweyn, iyo saameyn barar ah.

Xeryahooda polyphenol, oo sida caadiga ah laga helo tufaaxa, shaciir, iyo abuurka canabka, ayaa la soo jeediyay inay soo saaraan saamaynta kobcinta timaha iyagoo kor u qaadaya korriinka unugyada epithelial ee timaha iyo kicinta marxaladda koritaanka anagen ee firfircoon ee moodooyinka murinka ee vivo iyo bilaha 6 & 12 kiliinikada tijaabooyin.

Faa'iidooyinkaPROCYANIDIN B-2

Tallaabooyin ka hortag ah oo ka dhan ah korriinka catagen-ka, burburinta unugyada DNA-da (apoptosis), iyo timo luminta:

Daraasadani waxay baadhay xidhiidhka Procyanidin b-2 ee waddooyinka calaamadaha TGF-beta, kuwaas oo loo yaqaan inay kiciyaan marxaladda catagen (taas oo ah marxaladda timaha qallafsan), iyo borotiinka kinase cascade ee mitogen-activated (PKC), kaas oo ku xiran unugyada. fidinta. Daraasadani waxay ku dartay TGF-beta (1) iyo (2) dhaqamada unugyada epithelial timaha waxayna xustay in dariiqyadani ay si ku-tiirsan u yareeyeen korriinka unugyada iyo apoptosis ay keentay Koritaanka ama koritaanka noolaha). Si kastaba ha noqotee, ku darida procyanidin B-2 ee dhaqanka unugyada timaha ayaa ka takhalusay saameyntan koritaanka-horjoogta ah waxayna ka ilaalisay unugyada timaha apoptosis.

In ka badan 1,000 nooc oo dabiici ah ayaa la baaray...

Proanthocyanidins (oo ay ku jiraan procyanidin b-2) ee laga soosaaray abuurka canabka ayaa loo tixgaliyay inay tahay wax soo saar dabiici ah oo muhiim u ah koritaanka timaha, ka dib markii saynisyahannadu ay baareen in ka badan 1,000 nooc oo kala duwan oo geedo ah. Waxay ogaadeen in proanthocyanidins-yadani ay ku bateen unugyada timaha follicle ee jiirarka ilaa 230% marka loo eego kontaroolada (100%) waxayna leeyihiin "waxqabad cajiib ah oo timo-wareejin ah oo ka soo jeeda marxaladda telogen ilaa marxaladda anagen...". Markaa 1,000 ka mid ah falanqaynta laga soo saaray dhirta, iniinaha canabka ah ayaa dhammaantood kor u qaaday. Waxyaabaha ku jira abuurka canabka ah iyo sababta ay ugu guulaysteen korriinka timaha ayaa lagu dhexdhexaadiyaa iyada oo loo marayo xeryahooda kala duwan ee phenolic, awoodda antioxidant, wareegga dhiigga oo wanaajiyey, kor u qaadista kolajka iyo faa'iidooyinka kale. (waxbarasho). Abuurka abuurka canabku wuxuu ka kooban yahay noocyo kala duwan oo oligomeric proanthocyanidins ah oo leh kaliya 3.1% PB-2. Waxaan rabnaa waxyaabo badan oo PB-2 ah, sidaa darteed soosaarka abuurka canabka maaha mid xiiso u leh koritaanka gadhka (si kastaba ha ahaatee waxay noqon karaan koritaanka timaha).

Saamaynta Kobaca Unug Epithelial timaha

Si loo soo gabagabeeyo habka kobcinta korriinka ee hawlaha procyanidins, daraasaddan ayaa muujisay in procyanidin b-2 ay muujisay saameynta ugu badan ee kobcinta koritaanka timaha koritaanka unugyada epithelial. Natiijadan ayaa sheegaysa in procyanidin b-2 ay leedahay firfircoonida kor u qaadida korriinka ee unugyada epithelial murine timaha heerka ugu sarreeya ee 300% marka loo eego kontaroolada 5-maalin dhaqameed, waxayna sidoo kale muujiyeen in procyanidin oligomers ay kiciyaan anagen induction in vivo murine. moodel ku dhawaad ​​la mid ah xoojinta minoxidil 2%. Procyanidin b-2 waxay u soo baxday inay tahay polyphenol kobaca ugu sarreeya, marka la barbardhigo PB-3 iyo PC-1 (taas oo ah sababta soo saarista abuurka canabka aysan noqon doonin isha ugu fiican ee koritaanka gadhka).

Waxaa xiiso leh in la ogaado in daraasaddan ay kaliya eegtay codsiga jirka ee procyanidin oligomers oo leh 1% kaliya. Daraasadani waxay barbardhigtay kaliya 1% feejignaanta minoxidil 2%. Waxaa laga yaabaa in lagu qeexo in fiirsashada sare (sida 5%) ee procyanidin b-2 laga yaabo in si wanaagsan loo barbar dhigo Minoxidil 5%.

Daraasadani waxay muujinaysaa suurtagalnimada rajada ah ee procyanidin b2 in loo isticmaalo kicinta koritaanka timaha dabiiciga ah.

Tijaabooyin Caafimaad oo Aadanaha

Tijaabada caafimaadku waxay baadhis ku samaysay saamaynta kaliya ee 1% procyanidin b2 ee koritaanka timaha bini'aadamka kadib isticmaalka bilaha 6. Tijaabo caafimaad oo laba-indho la'aan ah oo ka kooban wadar ahaan 29 maado ayaa la sameeyay. 19 nin oo ka tirsan kooxda procyanidin B-2 iyo 10 nin oo ka tirsan kooxda kantaroolka placebo ayaa lagu sameeyay baaritaan. Wax saameyn xun ah laguma arag labada kooxoodba.

Natiijooyinka:

Korodhka tirada guud ee timaha ee aagga madaxa ee loo qoondeeyey (0.5 cm square = 0.25 cm2) ee maadooyinka kooxda procyanidin B-2 ka dib tijaabada 6-bilood ayaa aad uga weyn tan maadooyinka kooxda kontoroolka placebo (procyanidin B-2). , 6.68 +/- 5.53 (macnaha +/- SD)/0.25 cm2; placebo, 0.08 +/- 4.56 (macnaha +/- SD)/0.25 cm2; Korodhka tirada timaha terminaalka, kuwaas oo lagu qeexay inay yihiin timo ka badan 60 microm dhexroorka, ee aagga loo qoondeeyey (0.5 cm square = 0.25 cm2) ee maadooyinka kooxda procyanidin B-2 ka dib tijaabada 6-bilood ayaa si weyn u weynaaday. marka loo eego kuwa maadooyinka kooxda xakamaynta placebo (procyanidin B-2, 1.99 +/- 2.58 (macnaha +/- SD) / 0.25 cm2; placebo, -0.82 +/- 3.40 (macnaha +/- SD) / 0.25 cm2; P

Natiijooyinkani waxay muujinayaan in ragga isticmaalay PB2 ay si weyn u korodheen wadarta timaha koray, tirada timaha aan dhamaadka lahayn, iyo wax saameyn ah oo la soo sheegay.

Markii cilmi-baarayaashu ay barbar dhigeen natiijooyinkooda daawooyinka hadda la heli karo, waxay ogaadeen in procyanidin B-2 ay sababtay korriinka timaha wax yar ka yar minoxidil (2%, maaha 5%), laakiin koror weyn oo timaha guud ahaan marka loo eego finasteride (Proscar). Si ka duwan dawooyinkan dhakhtar qoray, procyanidin B-2 ma soo saarin wax saameyn ah. Daawaynta Procyanidin B-2 waxay tusinaysaa suurtogalnimada inay tahay daawo badbaado leh oo rajo leh oo loogu talagalay bidaarta qaabka labka ah.

Daraasad kale oo caafimaad, oo socotay muddo 12 bilood ah, ayaa baadhay waxtarka 0.7% oligomers procyanidin tufaax (mar kale, feejignaan aad u hooseeya weli natiijadu waxay ahayd mid muhiim ah).

Tijaabo caafimaad oo laba-indho la'aan ah oo ka kooban wadar ahaan 43 maado ayaa la sameeyay. 21 nin oo ka tirsan kooxda procyanidin iyo 22 nin oo ka tirsan kooxda kantaroolka placebo ayaa lagu sameeyay falanqayn. 6dii bilood ee ugu horeysay, waxaan is barbar dhignay procyanidin iyo kooxaha placebo si loo qiimeeyo saameynta daawada ee procyanidin oligomers. Wakhtiga codsiga kooxda procyanidin ka dib ayaa la kordhiyay ilaa 12 bilood, iyo wakhtiga koorsada qiimihiisa hagaajinta ayaa la baaray.

Korodhka tirada guud ee timaha ee aagga madaxa ee loo qoondeeyay maadooyinka kooxda procyanidin ka dib tijaabada 6-bilood ayaa aad uga weyn tan maadooyinka kooxda xakamaynta placebo (procyanidin, 3.3 +/- 13.0 (macnaha +/- SD)/ 0.50 cm (2); placebo, -3.6 +/- 8.1 / 0.50 cm (2); Koorsada waqtiga ku-tiirsanaanta ku-tiirsanaanta cufnaanta timaha ayaa lagu arkay maadooyinka procyanidin. Wax saameyn xun ah laguma arag mid ka mid ah maadooyinka. Daawaynta Procyanidin waxay markaa tusinaysaa waxqabad timaha kori kara.

Farmashiistaha & Farmacokinetics ee Procyanidin B-2

Pharmacology waa laanta daawadu ay khusayso isticmaalka, saamaynta, iyo hababka ficilka daawooyinka.

Pharmacokinetics waa laanta farmashiistaha ee ka welwelsan dhaqdhaqaaqa daroogada ee jirka.

Muhiim ma aha oo kaliya in la fiirsado oo la falanqeeyo hababka ficilka ee PB-2, waxaa muhiim ah in la ilaaliyo sida maaddadan loo nuugi karo, loo geli karo, iyo la heli karo si bayooloji ah marka dusha sare loo mariyo.

Daraasadani waxay u fiirsatay galitaanka PB2 ee looshanka oo leh 0.0663mg oo keliya. Natiijooyinku waxay muujiyeen in inkasta oo diiradda hoose ee looshanka, walaxda ayaa muujisay faa'iido leh marka loo eego farmashiyaha.

Fikrad ahaan 4-5% fiirsiga PB2 waa in ay soo bandhigtaa oo u soo gasho si wax ku ool ah, laakiin farmashiyaha qurxinta ee aan shaqaaleysiiyay ayaa ii xaqiijin doona haddii ay tani suurtogal tahay.

Kani miyaan sun ahayn oo badbaado u ah isticmaalka?

Si loo qiimeeyo badbaadada procyanidin B-2 ee jirka la mariyo sida wakiilka timaha u koraya, daraasaddan ayaa baadhay mutagenicity-ka, cirbadeynta ba'an ee subcutaneous, xanaaqa aasaasiga ah, dareenka maqaarka, iyo cuncunka indhaha ee xaruntan. Natiijooyinku waxay muujiyeen xaruntan inaysan lahayn wax saameyn ah oo mutagenic ah, ma jiraan wax qalooc ah oo dhisme ah, qiyaasta sharciga ah oo ka weyn 2000mg (durbaanka subcutaneous), ma jiro xanaaq asaasi ah oo ka dhex jira tijaabooyinka bakaylaha, iyo xanaaq yar marka la geliyo indhaha bakaylaha.

Tijaabooyinkii hore ee kiliinikada ee bini'aadamka sidoo kale ma muujin waxyeelo xun oo la soo sheegay. Daraasadihii hore ee lagu sheegay moodooyinka xuubka xuubka ma muujin waxyeellooyin xun midkoodna.

Natiijooyinkani waxay soo jeedinayaan in procyanidin b-2 ee jirka la mariyo uu yahay badbaado oo la aqbali karo in la isticmaalo.

Gebogebadii, Procyanidin B-2 waxay leedahay karti weyn waxaana si joogto ah loogu sahamiyaa faa'iidooyinkeeda caafimaad ee badan. Ballanqaadka Aogubio ee horumarinta nafaqeynta, kaabeyaasha iyo alaabooyinka warshado kala duwan iyadoo la adeegsanayo Procyanidin B-2 waxay hoosta ka xariiqaysaa sida ay uga go'an tahay shirkadda inay ka faa'iideysato awoodda walxaha dabiiciga ah si loo hagaajiyo caafimaadka aadanaha. Maaddaama cilmi-baarista iyo fahamka Procyanidin B-2 ay sii socoto horumarinta, waxaa cad in Procyanidin B-2 ee xoogga leh ay ballanqaad weyn u leedahay mustaqbalka caafimaadka dabiiciga ah.

Miranda Zhang