Kedu ihe bụ Adenosine?

Adenosine bụ nucleoside nke na-eme na sel niile nke ahụ. Kemịkalụ ọ bụ 6-amino-9-beta-D-ribofuranosyl-9-H-purine.

Ọdịdị na ọkwa ọbara

Adenosine bụ nke adenine jikọtara ya na molecule sugar ribose (ribofuranose). Njikọ nke jikọtara adenine na shuga ribose bụ nke a na-akpọ njikọ β-N9-glycosidic.

Ọkwa adenosine plasma na-emebu bụ n'etiti 0.04 na 0.2 micromoles.

Ọrụ physiological na ọgwụ ọgwụ nke Adenosine

N'ime ahụ, adenosine na-enyere aka na nnyefe ike cell site n'ịmepụta ụmụ irighiri ihe dị ka adenosine triphosphate (ATP) na adenosine diphosphate (ADP).

Adenosine na-ekerekwa òkè n'igosipụta ụzọ dị iche iche na ọrụ dị n'ime ahụ site n'ịmepụta ụmụ irighiri ihe dị ka cyclic adenosine monophosphate (cAMP).

Adenosine na ụbụrụ

Na ụbụrụ adenosine bụ ihe na-egbochi neurotransmitter. Nke a pụtara na adenosine nwere ike rụọ ọrụ dị ka onye na-akụda sistemu ụjọ nke etiti. N'ọnọdụ nkịtị, ọ na-akwalite ụra ma na-egbochi mkpali. Mgbe edemede nke adenosine dị n'ụbụrụ na-ebili kwa awa.

Adenosine n'ime obi

N'ime obi adenosine na-akpata mgbasa nke arịa ọbara nke na-eme ka ọbara na-erugharị n'obi. Adenosine na-abawanye dayameta nke arịa ọbara na akụkụ akụkụ ahụ.

N'ime obi adenosine na-ebelata ọnụọgụ obi yana n'ime ọbara ọ nwere ihe mgbochi platelet. Omume antiplatelet na-egbochi nchịkọta platelet na coagulation.

Adenosine n'ime ọbara

N'ime ọbara adenosine na-agbaji site na adenosine deaminase. Enzyme a dị na sel uhie na mgbidi arịa. Ọgwụ Dipyridamole bụ ihe na-egbochi enzyme adenosine deaminase ma si otú a na-ebuli ọkwa nke adenosine n'ọbara. Nke a na-eduga n'ịgbasa arịa ọbara na mmụba ọbara ka mma site na arịa ọbara akwara na-enye akwara obi.

Adenosine n'ime akụrụ, ngụgụ na imeju

N'ime akụrụ adenosine na-ebelata oke ọbara gbasara akụrụ ma belata mmepụta nke rennin site na akụrụ.

N'ime akpa ume ọ na-ebute mkpọchi nke ụzọ ikuku na imeju ọ na-eduga ná mkpọchi nke arịa ọbara ma na-abawanye ndakpọ glycogen iji mepụta glucose.

Adenosine bụ ihe sitere n'okike nke na-arụ ọrụ dị mkpa na usoro physiological dị iche iche na ahụ mmadụ. Ọ bụ nucleoside, nke pụtara na ọ bụ molecule adenine jikọtara ya na molecule ribose. Adenosine dị na sel niile ma na-etinye aka na nnyefe ike dị ka akụkụ nke adenosine triphosphate (ATP), ego bụ isi ike nke cell. Na mgbakwunye na ọrụ ya na metabolism ike, adenosine na-arụkwa ọrụ dị ka molekul na-egosi, na-eme site na ndị na-anabata ya kpọmkwem n'ime ahụ.

Otu n'ime isi akụkụ nke adenosine pharmacology bụ usoro ya. Adenosine na-arụ ọrụ site na ijikọta ndị na-anabata adenosine kpọmkwem, nke nwere subtypes anọ: A1, A2A, A2B, na A3. A na-ejikọta isoform ọ bụla na ọrụ physiological dị iche iche na ụzọ mgbaàmà. Mgbe adenosine na-ejikọta ya na ndị na-anabata ya, ọ na-achịkwa usoro dị iche iche nke cellular, gụnyere neurotransmission, ụda vaskụla, na ọrụ mgbochi. Dịka ọmụmaatụ, ịgbalite ndị na-anabata A1 nwere ike iduga nkwụsị nke ntọhapụ nke neurotransmitter, ebe ịgbalite ndị na-anabata A2A nwere ike iduga vasodilation na mmetụta mgbochi mkpali.

Ịghọta nkà mmụta ọgwụ nke adenosine na-eduga na ngwa ụlọ ọgwụ na ọnọdụ ahụike dị iche iche. Otu n'ime ọgwụgwọ kachasị mara nke adenosine bụ ọrụ ya na ọgwụgwọ ụfọdụ arrhythmias obi. A na-eji Adenosine mee ihe dị ka ihe na-egbochi ọrịa arrhythmic n'ihi ike ọ na-eme ka a na-emegharị ya ngwa ngwa site na oghere atrioventricular, si otú ahụ na-akpaghasị ụzọ ntinyeghachi azụ na iweghachi ụda nke sinus nkịtị. Ọzọkwa, a na-eji adenosine eme ihe dị ka onye na-ahụ maka nrụgide ọgwụ na ọmụmụ ihe gbasara obi iji chọpụta perfusion myocardial.

Na nchịkọta, adenosine bụ ihe dị iche iche nwere ọtụtụ ihe eji eme ụlọ ọgwụ n'ihi njirimara ọgwụ ya na usoro ọrụ ya. Ikike ya ịmegharị usoro cellular site na mmekọrịta ndị nnata kpọmkwem na-eme ka ọ bụrụ ngwá ọrụ bara uru n'ịgwọ ọrịa dịgasị iche iche, site na arrhythmias obi na ọrịa iku ume yana ngwa ndị nwere ike ime ihe na-adịghị mma. Ka nyocha banyere adenosine na-aga n'ihu, ojiji ụlọ ọgwụ ọhụrụ maka ụmụ irighiri ihe a na-adọrọ mmasị nwere ike ịga n'ihu na-apụta, na-agbasawanye ikike ọgwụgwọ ya na ọgwụ.

Pls jiri obiọma kpọtụrụ Alisa maka nkọwa ndị ọzọ site nasales02@imaherb.com