Kedu ihe bụ PROCYANIDIN B-2 (wepụtara na apụl)?

Kedu ihe bụ ihe ahụ?

Procyanidin B-2, bụ subclass nke flavonoids nke a maara na-arụ ọrụ antioxidant dị ike, ọgwụgwọ na mgbochi mkpali.

Ogige polyphenol ndị a, nke a na-ahụkarị na apụl, ọka bali, na mkpụrụ vaịn, ka akwadoro ka ha mepụta mmetụta na-akpali akpali ntutu site na ịkwalite uto cell epithelial ntutu na ịkpalite usoro uto anagen na-arụ ọrụ na ụdị vivo murine na ọnwa 6 & ọnwa 12. ọnwụnwa.

Uru nkePROCYANIDIN B-2

Omume mgbochi megide mmepe catagen, mbibi DNA cellular (apoptosis), na ntutu isi:

Ọmụmụ ihe a nyochara mmekọrịta Procyanidin b-2 na ụzọ mgbaàmà TGF-beta, bụ ndị a maara na-ebute usoro catagen (nke bụ ntutu isi na-emebi emebi), na protein kinase cascade nke mitogen-activated (PKC), nke jikọtara ya na cell. mmụba. Ọmụmụ ihe a gbakwunyere TGF-beta (1) na (2) na omenala epithelial cell ntutu wee chọpụta na ụzọ ndị a na-adabere na-ebelata uto cell na apoptosis kpatara (apoptosis bụ ọnwụ nke mkpụrụ ndụ nke na-eme dị ka akụkụ nkịtị na nke a na-achịkwa. uto ma ọ bụ mmepe organism). Otú ọ dị, mgbakwunye procyanidin B-2 na omenala ntutu isi na-ewepụ mmetụta ndị a na-egbochi uto ma chebe mkpụrụ ndụ ntutu site na apoptosis.

A nyochara ihe karịrị 1,000 sitere n'okike...

A na-ewere proanthocyanidins (gụnyere procyanidin b-2) sitere na mkpụrụ vine dị ka ihe dị mkpa sitere n'okike maka uto ntutu, mgbe ndị ọkà mmụta sayensị nyochachara ihe karịrị 1,000 ụdị ihe ọkụkụ dị iche iche. Ha chọpụtara na ndị a proanthocyanidins mụbara mkpụrụ ndụ follicle ntutu n'ime ụmụ oke ihe dịka 230% n'ihe metụtara njikwa (100%) ma nwee "ọrụ mgbanwe ntutu dị ịrịba ama site na oge telogen ruo oge anagen...". Ya mere, n'ime 1,000 nyocha nke ihe ọkụkụ, mkpụrụ vine karịrị ha niile. Ihe ndị dị n'ime mkpụrụ osisi vine na ihe mere ha ji nwee ọganihu na ntutu isi bụ ndị a na-agbanye site na ogige phenolic dị iche iche, ike antioxidant, mgbasa ọbara ka mma, nkwalite nke collagen na uru ndị ọzọ. (ihe omumu). Mkpokọta mkpụrụ vine mejupụtara proanthocyanidin oligomeric dị iche iche nwere naanị ihe dịka 3.1% PB-2. Anyị na-achọkwu ọdịnaya PB-2, ya mere, mkpụrụ osisi grape enweghị mmasị maka uto ajị agba (n'agbanyeghị na ha nwere ike ịbụ maka ntutu isi).

Mmetụta uto cell Epithelial ntutu

Iji kwubie n'usoro ọrụ na-akwalite uto nke procyanidins ndị a, nchọpụta a gosipụtara na procyanidin b-2 gosipụtara mmetụta kachasị na-akwalite uto maka ntutu epithelial cell. Nchọpụta a na-akọ na procyanidin b-2 nwere ọrụ na-akwalite uto na mkpụrụ ndụ epithelial ntutu murine n'ogo kachasị elu nke 300% na njikwa na omenala 5 ụbọchị, ma gosipụtakwala na procyanidin oligomers na-akpali anagen induction na vivo murine. ihe nlereanya na ihe fọrọ nke nta ka ọ bụrụ otu ike dị ka minoxidil 2%. Procyanidin b-2 pụtara dị ka polyphenol kachasị na-akwalite uto, ma e jiri ya tụnyere PB-3 na PC-1 (nke mere na mwepu mkpụrụ vaịn agaghị abụ ihe kacha mma maka uto ajị agba).

Ọ bụ ihe na-adọrọ mmasị ịmara na ọmụmụ ihe a nyochara ngwa ngwa nke procyanidin oligomer ndị a na ntinye naanị 1%. Ọmụmụ ihe a tụnyere naanị 1% itinye uche ya na minoxidil 2%. Enwere ike ịkọwapụta na ntinye uche dị elu (dị ka 5%) nke procyanidin b-2 nwere ike iji ya tụnyere nke Minoxidil 5%.

Ọmụmụ ihe a na-egosiputa ikike dị mma maka procyanidin b2 iji mee ihe na-eme ka ntutu na-eto eto.

Ọnwụnwa ụlọ ọgwụ mmadụ

Nnwale ụlọ ọgwụ a nyochara mmetụta nke naanị 1% procyanidin b2 na uto ntutu mmadụ mgbe ejiri ya mee ihe maka ọnwa 6. Emere ule ụlọ ọgwụ kpuru okpukpu abụọ nke gụnyere mkpokọta ihe ọmụmụ 29. A na-enyocha ndị ikom 19 n'ime ìgwè procyanidin B-2 na ndị ikom 10 nọ n'òtù ndị na-achịkwa placebo. Ọnweghị mmetụta ọjọọ a hụrụ n'otu ọ bụla.

Nsonaazụ:

Mmụba nke ọnụ ọgụgụ ntutu zuru ezu na mpaghara isi isi a họpụtara (0.5 cm square = 0.25 cm2) nke ihe gbasara otu procyanidin B-2 mgbe ikpe ọnwa 6 gasịrị dị ukwuu karịa nke ndị na-achịkwa placebo (procyanidin B-2). , 6.68 +/- 5.53 (pụtara +/- SD) / 0.25 cm2; placebo, 0.08 +/- 4.56 (pụtara +/- SD) / 0.25 cm2; P

Nsonaazụ ndị a na-ekpughe na ndị ikom ji PB2 nwere mmụba dị ukwuu na ntutu isi tolitere, ọnụ ọgụgụ nke ntutu isi, na enweghị mmetụta ọ bụla a kọrọ.

Mgbe ndị nyocha ahụ jiri nsonaazụ ha tụnyere nke ọgwụ ndị dị ugbu a, ha chọpụtara na procyanidin B-2 mere ka ntutu dị ntakịrị belata karịa minoxidil (na 2%, ọ bụghị 5%), mana mmụba dị ukwuu na ntutu isi karịa finasteride (Proscar). N'adịghị ka ọgwụ ndị a na-ede ọgwụ, procyanidin B-2 enweghị mmetụta ọ bụla. Usoro ọgwụgwọ Procyanidin B-2 na-egosi ike dị ka ọgwụgwọ dị mma na nke na-ekwe nkwa maka isi nkwọcha nwoke.

Ọmụmụ ụlọ ọgwụ ọzọ, nke dịruru ọnwa 12, nyochara ịdị irè nke 0.7% apple procyanidin oligomers (ọzọ, ntinye uche dị ala ma nsonaazụ ya ka dị ịrịba ama).

Emere ule ụlọ ọgwụ kpuru okpukpu abụọ nke gụnyere ngụkọta nke isiokwu 43. A na-enyocha ndị ikom 21 n'ime ìgwè procyanidin na ndị ikom 22 nọ na-achịkwa placebo. N'ime ọnwa isii mbụ, anyị tụlere procyanidin na ndị otu placebo iji chọpụta mmetụta ọgwụ nke procyanidin oligomers. E mechara gbasaa oge ntinye nke otu procyanidin na ọnwa 12, ma nyochaa oge nke uru mmezi ya.

Mmụba nke ngụkọta ọnụ ọgụgụ nke ntutu isi na mpaghara isi isi a họpụtara ahọpụta nke ndị otu procyanidin mgbe nnwale nke ọnwa 6 dị ukwuu karịa nke ndị na-ahụ maka njikwa placebo (procyanidin, 3.3 +/- 13.0 (pụtara +/- SD)/ 0.50 cm (2); placebo, -3.6 +/- 8.1 / 0.50 cm (2); P

Pharmacology & Pharmacokinetics nke Procyanidin B-2

Pharmacology bụ ngalaba ọgwụ metụtara ojiji, mmetụta, na ụdị omume nke ọgwụ.

Pharmacokinetics bụ ngalaba nke nkà mmụta ọgwụ na-emetụta mmegharị ọgwụ n'ime ahụ.

Ọ bụghị naanị na ọ dị mkpa ileba anya na nyochaa usoro nke ime ihe maka PB-2, ọ dị mkpa ịhụ ka ihe a ga-esi banye, banye, ma dị na ndụ mgbe etinyere ya n'elu.

Ọmụmụ ihe a hụrụ ntinye nke PB2 na ude mmiri nwere naanị 0.0663mg. Nsonaazụ gosiri na n'agbanyeghị obere itinye uche na ude mmiri ahụ, ihe ahụ gosipụtara bara uru n'ihe gbasara ọgwụ pharmacokinetics.

Ntụle echiche 4-5% nke PB2 kwesịrị inye ma banye nke ọma, mana onye ịchọ mma chemist m goro ga-akwado m ma ọ bụrụ na nke a ga-ekwe omume.

Nke a ọ naghị egbu egbu ma dịkwa mma maka ojiji?

Iji nyochaa nchekwa nke procyanidin B-2 dị n'elu dị ka onye na-eto eto ntutu, nchọpụta a nyochara mutagenicity, nnukwu injection subcutaneous, mgbakasị mbụ, mmetụta anụ ahụ, na iwe anya nke ogige a. Nsonaazụ gosiri na onyinye a enweghị mmetụta mutagenic, ọ nweghị mmebi usoro, usoro iwu karịrị 2000mg (ntụtụ subcutaneous), enweghị mgbakasị mbụ n'etiti ule na oke bekee, yana obere iwe mgbe etinyere ya n'anya oke bekee.

Nnwale ụlọ ọgwụ ndị gara aga na ụmụ mmadụ gosikwara enweghị mmetụta ọjọọ a kọrọ. Ihe ọmụmụ ndị a kpọtụrụ aha na mbụ na ụdị murine egosighi mmetụta ọjọọ ọ bụla.

Nsonaazụ ndị a na-egosi na procyanidin b-2 dị n'elu dị mma ma na-anabata ya maka ojiji.

N'ikpeazụ, Procyanidin B-2 nwere ikike dị ukwuu ma na-enyocha ya mgbe niile maka ọtụtụ uru ahụike ya. Nkwenye Aogubio n'ịmepụta ihe ndị na-edozi ahụ, ihe mgbakwunye na ngwaahịa maka ụlọ ọrụ dị iche iche site na iji Procyanidin B-2 na-emesi nkwenye ụlọ ọrụ ahụ iji nweta ike nke ihe ndị sitere n'okike iji meziwanye ahụike mmadụ. Ka nyocha na nghọta nke Procyanidin B-2 na-aga n'ihu na-agbanwe, o doro anya na Procyanidin B-2 dị ike nwere nnukwu nkwa maka ọdịnihu nke ahụike anụ ahụ.

Miranda Zhang