Aogubio SNAP-8 Anti-Wrinkle Peptide

SNAP-8 ndi anti-wrinkle octapeptide yomwe ndi mtundu wautali wa hexapeptide Argireline yotchuka. SNAP-8 ndi chidule cha dzina lake lonse la Synaptosomoal-associated protein 25. Monga octapeptide, peptide iyi imapangidwa ndi tcheni cha polypeptide chomwe chimagwirizanitsa 8 amino acid. Imatchedwanso Acetyl Glutamyl Heptapeptide-1 kapena Acetyl Octapeptide ndipo imakhala ndi molekyulu yolemera 1075.16 Daltons ndipo mamolekyu ake ndi C14H70N16O16S1.SNAP-8 imatsanzira mapeto a N-terminal a SNAP-25 ndipo motero amapikisana ndi SNAP- 25 paudindo mkati mwa zovuta za SNARE zomwe zimapangitsa kusinthidwa kwa mapangidwe ake (SNARE complex). SNAP-25 ndi ya m'banja la t-SNARE la mamembala pafupifupi 60 ndipo imathandizira kusakanikirana kwa membrane ndipo makamaka imathandizira kuphatikizika popanga cholimba chomwe chimagwirizanitsa ma synaptic vesicle ndi plasma membranes. Kuwonongeka pang'ono kwa zovuta za SNARE kumalepheretsa kutulutsidwa kwabwino kwa ma neurotransmitters ndi vesicle ndipo izi zimabweretsa kutsika kwa minofu, kuteteza mapangidwe a makwinya ndi mizere.

Mofananamo ndi Argireline, SNAP-8 imalepheretsa mapangidwe a SNARE complex komanso imalepheretsa kutulutsidwa kwa catecholamine, izi zimabweretsa kuchepa kwa makwinya omwe alipo (amachepetsa kuya kwa makwinya a nkhope omwe amayamba chifukwa cha kuchepa kwa makwinya a nkhope. minyewa ya nkhope, makamaka yomwe ili pamphumi ndi m'dera lamaso) ndipo imalepheretsa kukula kwawo ikagwiritsidwa ntchito pafupipafupi. SNAP-8 imagwira ntchito ngati inhibitor ya kukangana kwa minofu ndipo motero imalola kuti minofu ikwaniritse njira zokhazikika zopezera homeostasis. Zimalimbikitsanso kupanga ndi kutulutsidwa kwa collagen kuchokera ku maselo, izi zimalimbitsa maselo, kuwapangitsa kuti achepetse mizere yabwino ndi mizere.