Kodi PROCYANIDIN B-2 (yotengedwa kuchokera ku maapulo) ndi chiyani?

Chimenecho ndi chiyani?

Procyanidin B-2, ndi gulu laling'ono la flavonoids lomwe limadziwika kuti lili ndi antioxidant yamphamvu, yochizira, komanso yotsutsa-kutupa.

Mankhwalawa a polyphenol, omwe amapezeka mu maapulo, balere, ndi njere za mphesa, adanenedwa kuti apangitse kukula kwa tsitsi polimbikitsa kukula kwa tsitsi la epithelial cell ndikulimbikitsa kukula kwa anagen mumitundu ya vivo murine komanso m'miyezi 6 & 12 yachipatala. mayesero.

Ubwino waPROCYANIDIN B-2

Zodzitetezera pakukula kwa catagen, kuwonongeka kwa ma cell a DNA (apoptosis), ndi kutayika tsitsi:

Kafukufukuyu adawunikira ubale wa Procyanidin b-2 ndi njira za TGF-beta, zomwe zimadziwika kuti zimathandizira gawo la catagen (lomwe ndi gawo lopusitsa tsitsi), komanso ma protein kinase cascade (PKC), omwe amalumikizidwa ndi cell. kuchuluka. Kafukufukuyu adawonjezera TGF-beta (1) ndi (2) ku chikhalidwe cha cell epithelial cell ndipo adawona kuti njirazi zimachepetsa kukula kwa maselo ndikupangitsa kuti apoptosis (apoptosis ndi kufa kwa maselo omwe amapezeka ngati gawo lachibadwa komanso lolamuliridwa). kukula kapena kukula kwa chamoyo). Komabe, kuwonjezera kwa procyanidin B-2 ku chikhalidwe cha tsitsi la tsitsi kunalepheretsa izi kukula ndikuteteza maselo atsitsi ku apoptosis.

Zopitilira 1,000 zachilengedwe zidawunikidwa ...

Ma proanthocyanidins (kuphatikiza procyanidin b-2) ochokera ku mbewu za mphesa adadziwika kuti ndiwofunikira kwambiri pakumera kwa tsitsi, asayansi atafufuza mitundu yopitilira 1,000 yamitundu yosiyanasiyana yazitsamba. Iwo adapeza kuti ma proanthocyanidins amachulukitsa ma cell follicle atsitsi mu mbewa pafupifupi 230% poyerekeza ndi zowongolera (100%) ndipo anali ndi "ntchito yodabwitsa yotembenuza tsitsi kuchokera ku gawo la telogen kupita ku gawo la anagen ...". Chifukwa chake, mwa kusanthula 1,000 pazamasamba, mbewu zamphesa zidaposa zonse. Zomwe zili mumbewu yamphesa ndi chifukwa chake chopambana pakukula kwa tsitsi zimayanjanitsidwa ndi mankhwala ake osiyanasiyana a phenolic, mphamvu ya antioxidant, kupititsa patsogolo kayendedwe ka magazi, kupititsa patsogolo collagen ndi zina zabwino. (maphunziro). Mbeu za mphesa zimapanga mitundu yosiyanasiyana ya oligomeric proanthocyanidins yokhala ndi 3.1% PB-2 yokha. Tikufuna zambiri za PB-2, kotero kuti zotsalira za mphesa sizikhala ndi chidwi pakukula kwa ndevu (ngakhale zingakhale za kukula kwa tsitsi).

Tsitsi Epithelial Cell Zotsatira Zakukula

Pomaliza pa njira yolimbikitsira ntchito za ma procyanidin awa, kafukufukuyu adawonetsa kuti procyanidin b-2 idawonetsa zotsatira zazikulu zolimbikitsira kukula kwa cell epithelial cell. Kupeza uku kukuwonetsa kuti procyanidin b-2 ili ndi ntchito yolimbikitsa kukula m'maselo a epithelial a murine pamlingo wapamwamba kwambiri wa 300% wokhudzana ndi zowongolera pachikhalidwe chamasiku a 5, komanso awonetsa kuti procyanidin oligomers imapangitsa kuti anagen induction mu vivo murine. chitsanzo pafupifupi mofanana mwamphamvu monga minoxidil 2%. Procyanidin b-2 anaonekera monga pazipita kukula-kulimbikitsa polyphenol, poyerekeza ndi PB-3 ndi PC-1 (ndicho chifukwa mphesa Tingafinye mbewu sadzakhala gwero yabwino kukula ndevu).

Ndizosangalatsa kudziwa kuti kafukufukuyu adangoyang'ana momwe ma oligomer a procyanidin awa amangogwiritsa ntchito ndi 1% yokha. Phunziroli limangoyerekeza ndende yake ya 1% ndi minoxidil 2%. Zitha kunenedwa kuti kuchuluka kwakukulu (monga 5%) kwa procyanidin b-2 kungafanane bwino ndi Minoxidil 5%.

Kafukufukuyu akuwonetsa kuthekera kolonjeza kwa procyanidin b2 kuti igwiritsidwe ntchito ngati choyambitsa tsitsi lachilengedwe.

Mayesero Achipatala a Anthu

Chiyeso chachipatalachi chinafufuza zotsatira za 1% procyanidin b2 yokha pa kukula kwa tsitsi laumunthu pambuyo pa kugwiritsidwa ntchito kwa miyezi 6. Kuyesedwa kwachipatala kwapawiri komwe kumaphatikizapo maphunziro a 29 kunachitidwa. Amuna 19 mu gulu la procyanidin B-2 ndi amuna 10 mu gulu lolamulira la placebo adayesedwa. Palibe zotsatira zoyipa zomwe zidawonedwa mu gulu lililonse.

Zotsatira:

Kuwonjezeka kwa chiwerengero cha tsitsi lonse m'dera la scalp (0.5 cm lalikulu = 0.25 cm2 dera) la gulu la procyanidin B-2 pambuyo pa mayesero a miyezi 6 linali lalikulu kwambiri kuposa la gulu lolamulira la placebo (procyanidin B-2). , 6.68 +/- 5.53 (kutanthauza +/- SD)/0.25 cm2; 4.56 (amatanthauza +/- SD) / 0.25 cm2 P

Zotsatira izi zikuwonetsa kuti amuna omwe adagwiritsa ntchito PB2 anali ndi chiwonjezeko chachikulu cha tsitsi lonse lomwe lakula, kuchuluka kwa tsitsi lomaliza, ndipo palibe zotsatirapo.

Ofufuzawo atayerekezera zotsatira zawo ndi mankhwala omwe alipo panopa, adapeza kuti procyanidin B-2 inachititsa kuti tsitsi likhale lochepa kwambiri kuposa minoxidil (pa 2%, osati 5%), koma kuwonjezeka kwakukulu kwa tsitsi lonse kuposa finasteride (Proscar). Mosiyana ndi mankhwalawa, procyanidin B-2 sinatulutse zotsatira zoyipa. Thandizo la Procyanidin B-2 likuwonetsa kuthekera ngati mankhwala otetezeka komanso odalirika a dazi lachimuna.

Kafukufuku wina wachipatala, yemwe adatenga miyezi 12, adafufuza momwe 0,7% ya apulo procyanidin oligomers imayendera (kachiwiri, ndende yotsika kwambiri komabe zotsatira zake zinali zofunikabe).

Kuyesedwa kwachipatala kwapawiri komwe kumaphatikizapo maphunziro a 43 kunachitidwa. Amuna a 21 mu gulu la procyanidin ndi amuna 22 mu gulu lolamulira la placebo adayesedwa. M'miyezi yoyamba ya 6, tinayerekezera procyanidin ndi magulu a placebo kuti tiwone zotsatira za mankhwala a procyanidin oligomers. Nthawi yogwiritsira ntchito gulu la procyanidin pambuyo pake inapitilizidwa kwa miyezi 12, ndipo nthawi ya mtengo wake wokonzanso inayesedwa.

Kuwonjezeka kwa tsitsi lonse m'dera losankhidwa la scalp la gulu la procyanidin pambuyo pa mayesero a miyezi ya 6 linali lalikulu kwambiri kuposa la gulu lolamulira la placebo (procyanidin, 3.3 +/- 13.0 (kutanthauza +/- SD)/ 0.50 cm(2), -3.6 +/- 8.1/0.50 cm(2); t-mayeso awiri). Kuwongolera kotengera nthawi ya kachulukidwe tsitsi kunawonedwa m'maphunziro a procyanidin. Palibe zotsatira zoyipa zomwe zidawonedwa pamitu iliyonse. Mankhwala a procyanidin amawonetsa ntchito yokulitsa tsitsi.

Pharmacology & Pharmacokinetics ya Procyanidin B-2

Pharmacology ndi nthambi yazamankhwala yomwe imakhudzidwa ndi kagwiritsidwe ntchito ka mankhwala, zotsatira zake, ndi machitidwe ake.

Pharmacokinetics ndi nthambi ya pharmacology yokhudzana ndi kayendedwe ka mankhwala mkati mwa thupi.

Sikofunikira kokha kuyang'ana ndikuwunika momwe PB-2 imagwirira ntchito, ndikofunikira kuyang'ana momwe chophatikizirachi chingatengedwere, kulowetsedwa, ndi kupezeka mwachilengedwe pakagwiritsidwa ntchito pamutu.

Kafukufukuyu adawona kulowerera kwa PB2 mu lotion yokhala ndi 0.0663mg yokha. Zotsatira zake zidawonetsa kuti ngakhale mafuta odzola amakhala ochepa, mankhwalawa adakhala othandiza pankhani ya pharmacokinetics.

Chiyembekezo cha 4-5% cha PB2 chiyenera kuperekedwa ndikulowa bwino, koma katswiri wodzikongoletsera yemwe ndinamulemba ntchito adzanditsimikizira ngati izi zingatheke.

Kodi izi sizowopsa komanso zotetezeka kuti mugwiritse ntchito?

Kuwunika chitetezo cha topical procyanidin B-2 ngati chokulitsa tsitsi, kafukufukuyu adasanthula mutagenicity, jekeseni wocheperako kwambiri, kuyabwa koyamba, kukopa khungu, komanso kuyabwa kwamaso kwa mankhwalawa. Zotsatira zinawonetsa kuti mankhwalawa alibe zotsatira za mutagenic, palibe kusintha kwapangidwe, mlingo walamulo ndi waukulu kuposa 2000mg (jekeseni wa subcutaneous), palibe kupsa mtima kwakukulu pakati pa mayesero a akalulu, ndi kupsa mtima pang'ono pamene alowetsedwa m'maso mwa kalulu.

Mayesero am'mbuyomu azachipatala pa anthu adawonetsanso kuti palibe zotsatirapo zoyipa zomwe zidanenedwa. Maphunziro omwe atchulidwa m'mbuyomu pamitundu ya murine sanawonetse zotsatira zoyipa.

Zotsatirazi zikusonyeza kuti topical procyanidin b-2 ndi yotetezeka komanso yovomerezeka kuti igwiritsidwe ntchito.

Pomaliza, Procyanidin B-2 ili ndi kuthekera kwakukulu ndipo ikufufuzidwa nthawi zonse chifukwa cha zabwino zake zambiri zaumoyo. Kudzipereka kwa Aogubio pakupanga zakudya zopatsa thanzi, zowonjezera ndi zinthu zamafakitale osiyanasiyana pogwiritsa ntchito Procyanidin B-2 zikugogomezera kudzipereka kwa kampaniyo kugwiritsa ntchito mphamvu za zinthu zachilengedwe kuti anthu akhale ndi thanzi labwino. Pamene kafukufuku ndi kumvetsetsa kwa Procyanidin B-2 kukupitirizabe kusinthika, zikuwonekeratu kuti Procyanidin B-2 yamphamvu ili ndi lonjezo lalikulu la tsogolo la thanzi lachilengedwe.

Miranda Zhang