Ukulawula Ukulutha Nezifiso Nge-N-Acetylcysteine: Indlela Esekelwe Ebufakazini
Ukulutheka kuyisimo esiyinkimbinkimbi esithinta izigidi zabantu emhlabeni wonke. Kungakhathaliseki ukuthi ukusebenzisa kabi izidakamizwa, ukugembula, nanoma yikuphi okunye ukuziphatha okuyimpoqo, ukulutheka kungaba nemiphumela elimazayo kubantu ngabanye nakubantu ababathandayo. Nakuba kunezinketho zokwelashwa ezihlukahlukene ezitholakalayo, i-N-Acetylcysteine (NAC) iye yavela njengethuluzi elithembisayo ekulawuleni ukulutheka nokulangazelela.
I-NAC iyinhlanganisela eyenzeka ngokwemvelo futhi itholakala kabanzi njengesengezo sokudla ngendlela yempushana. Ifundelwe kabanzi ngamakhono ayo okwelapha, ikakhulukazi emkhakheni wokulutheka. Ucwaningo selukhombisile ukuthi i-NAC inganciphisa ngempumelelo izifiso kanye nezimpawu zokuhoxa ezihambisana nokulutheka.
Enye yezindlela ezibalulekile i-NAC esebenza ngayo iwukugcwalisa i-glutathione, i-antioxidant ebalulekile ebuchosheni. I-Glutathione isiza ukulawula uhlelo lokuvuza lobuchopho, oluphazamiseka kakhulu ekuluthweni. Ngokubuyisela amazinga e-glutathione, i-NAC isiza ukulinganisa kabusha uhlelo lokuklomelisa, ukunciphisa izifiso ezinamandla ezitholwa abantu abanomlutha.
Ngaphezu kwalokho, i-NAC itholakale imodela izinhlelo eziningana ze-neurotransmitter ebuchosheni ezibandakanyeka ekuluthweni. Ithonya amazinga e-dopamine, i-neurotransmitter ehambisana nenjabulo nomvuzo, kanye ne-glutamate, i-neurotransmitter ehilelekile ekufundeni nasekukhumbuleni. Ngokulawula lawa ma-neurotransmitters, i-NAC ingasiza ekubuyiseleni ukusebenza kobuchopho okuvamile futhi inciphise isifiso sokuzibandakanya ekuziphatheni okuluthayo.
Ucwaningo oluningi lukhombise ukusebenza kahle kwe-NAC ekulawuleni ukulutheka kanye nezifiso. Ucwaningo olushicilelwe kuyi-American Journal of Psychiatry luthole ukuthi i-NAC inciphise kakhulu izifiso ze-cocaine futhi yathuthukisa izinga lokuzithiba kubantu abanomlutha we-cocaine. Olunye ucwaningo olwanyatheliswa kuyi-Journal of Clinical Psychopharmacology lubonise ukuthi i-NAC yehlisa izifiso ze-nicotine futhi yathuthukisa amazinga okuyeka ukubhema kubantu abanomlutha kagwayi.
I-NAC iphinde yakhombisa isithembiso ekwelapheni ezinye izidakamizwa, njengokugembula kanye nokulutha kwe-inthanethi. Ucwaningo olushicilelwe kumagazini i-Biological Psychiatry luhlole imiphumela ye-NAC kubantu abanenkinga yokugembula futhi lwathola ukuthi kunciphisa kakhulu izifiso zokugembula kanye namakhono okuthatha izinqumo athuthukile. Ngokufanayo, ucwaningo olushicilelwe ku-Journal of Clinical Psychopharmacology luphenye imiphumela ye-NAC ekuluthweni kwe-inthanethi futhi lwabika ukuncipha okukhulu kwezifiso nokulawula umfutho okuthuthukisiwe.
Okubalulekile, ukusetshenziswa kwe-NAC ekulawuleni ukulutheka kusekelwa ubufakazi obuqinile besayensi. Kuye kwacwaningwa kabanzi kuzo zombili izifundo zezilwane nezabantu, nokutholakele okungaguquki okusekela ukusebenza kahle kwayo. Ukwengeza, i-NAC inephrofayili yokuphepha esungulwe kahle futhi ivame ukubekezelelwa kahle, okuyenza ibe inketho efanelekile yokusebenzisa isikhathi eside.
Nakuba i-NAC ibonisa imiphumela ethembisayo ekulawuleni ukulutheka kanye nezifiso, akufanele kubhekwe njengokwelashwa okuzimele. Isebenza kahle kakhulu uma isetshenziswa njengengxenye yohlelo lokwelapha oluphelele oluhlanganisa ukwelapha, ukwelulekwa, namaqembu okusekela. I-NAC ingabonwa njengokwelashwa okuhlanganisayo okusiza abantu ukuba bazibandakanye kangcono enqubweni yokululama ngokunciphisa izifiso nokuthuthukisa inhlalakahle jikelele.
Sengiphetha, ukuluthwa wudaba olusabalele oludinga izindlela zokwelapha ezisebenzayo. I-N-Acetylcysteine (NAC) ivele njengethuluzi elithembisayo ekulawuleni ukulutheka kanye nezifiso. Ngamandla ayo okubuyisela ukusebenza kobuchopho, ukulungisa izinhlelo ze-neurotransmitter, nokunciphisa izifiso, i-NAC inikeza ithemba kubantu abafuna ukululama. Kodwa-ke, kubalulekile ukukhumbula ukuthi i-NAC kufanele isetshenziswe ngokuhambisana nezinye izindlela zokwelapha ukuze kube nemiphumela emihle. Uma wena noma othile omaziyo enenkinga yokulutheka, thintana nochwepheshe bezempilo ukuze nixoxe ngokuthi i-NAC iyindlela efanelekile yini.
Incazelo Yomkhiqizo
I-N-acetyl cysteine (NAC) ivela ku-amino acid L-cysteine. Ama-amino acid ayizingqimba zokwakha amaprotheni. I-NAC inokusetshenziswa okuningi futhi iwumuthi ogunyazwe yi-FDA.
I-N-acetyl cysteine i-antioxidant engase ibambe iqhaza ekuvimbeleni umdlavuza. Njengomuthi, usetshenziswa abahlinzeki bezempilo ukwelapha ubuthi be-acetaminophen (Tylenol). Isebenza ngokubopha izinhlobo ezinobuthi ze-acetaminophen ezakheka esibindini.
Abantu bavame ukusebenzisa i-N-acetyl cysteine ukukhwehlela nezinye izimo zamaphaphu. Ibuye isetshenziselwe umkhuhlane, iso elomile, nezinye izimo eziningi, kodwa abukho ubufakazi obuhle besayensi obusekela okuningi kwalokhu kusetshenziswa. Abukho futhi ubufakazi obuhle bokusekela ukusebenzisa i-N-acetyl cysteine ye-COVID-19.
I-N-Acetyl-L-Cysteine iyi-amino acid, ingashintshwa isuka emzimbeni we-methionine, i-cystine ingaguqulwa nomunye nomunye. I-N-Acetyl-l-cysteine ingasetshenziswa njenge-ejenti ye-mucilagenic. Ifanele ukuvinjelwa kokuphefumula okubangelwa inani elikhulu lokuvinjelwa kwe-phlegm. Ngaphezu kwalokho, ingasetshenziswa futhi ukuqeda ubuthi obunobuthi be-acetaminophen.
Umsebenzi
I-N-Acetyl-L-Cysteine iyi-amino acid, ingashintshwa isuka emzimbeni we-methionine, i-cystine ingaguqulwa nomunye nomunye. I-N-Acetyl-l-cysteine ingasetshenziswa njenge-ejenti ye-mucilagenic. Ifanele ukuvinjelwa kokuphefumula okubangelwa inani elikhulu lokuvinjelwa kwe-phlegm. Ngaphezu kwalokho, ingasetshenziswa futhi ukuqeda ubuthi obunobuthi be-acetaminophen.
