Iyini i-PROCYANIDIN B-2 (ekhishwe kuma-apula)?

Yini leyo?

I-Procyanidin B-2, iyi-subclass ye-flavonoid eyaziwa ngokuba nemiphumela enamandla ye-antioxidant, yokwelapha, ne-anti-inflammatory.

Lezi zinhlanganisela ze-polyphenol, ezivame ukutholakala kuma-apula, ibhali, nembewu yamagilebhisi, ziye zaphakanyiswa ukuthi zikhiqize imiphumela evuselelayo yokukhula kwezinwele ngokukhuthaza ukukhula kwamangqamuzana ezinwele ze-epithelial kanye nokugqugquzela isigaba esisebenzayo sokukhula kwe-anagen kumamodeli e-vivo murine kanye nezinyanga ezingu-6 & 12 izinyanga zomtholampilo. izilingo.

Izinzuzo zeI-PROCYANIDIN B-2

Izenzo zokuvimbela ngokumelene nokuthuthukiswa kwe-catagen, ukubhujiswa kwe-DNA yeselula (i-apoptosis), nokulahlekelwa izinwele:

Lolu cwaningo luhlole ubudlelwano be-Procyanidin b-2 nezindlela zesignali ye-TGF-beta, ezaziwa ngokuheha isigaba se-catagen (okuyisigaba sezinwele eziwohlokayo), kanye ne-mitogen-activated protein kinase cascade (PKC), exhunywe kuseli. ukwanda. Lolu cwaningo lwengeze i-TGF-beta(1) kanye (2) kumaseli ezinwele ze-epithelial cell futhi lwaphawula ukuthi lezi zindlela zehlisa ukukhula kwamaseli ngokuncika futhi zenze i-apoptosis (i-apoptosis ukufa kwamaseli okwenzeka njengengxenye evamile nelawulwayo ye-apoptosis). ukukhula noma ukukhula komzimba). Kodwa-ke, ukungezwa kwe-procyanidin B-2 kusiko lamaseli ezinwele kwehlisa le miphumela evimbela ukukhula futhi kwavikela amangqamuzana ezinwele ku-apoptosis.

Zingaphezu kuka-1,000 izingcaphuno zemvelo ezihloliwe...

I-proanthocyanidins (kuhlanganise ne-procyanidin b-2) ekhishwe kumbewu yamagilebhisi kuthiwa iyisiphuzo semvelo esibalulekile ekukhuleni kwezinwele, ngemva kokuba ososayensi behlole izinhlobo ezingaphezu kuka-1,000 zezitshalo ezihlukene. Bathole ukuthi lawa ma-proanthocyanidin andisa amaseli e-follicle yezinwele kumagundane cishe ngo-230% uma kuqhathaniswa nezilawuli (100%) futhi abe "nomsebenzi omangalisayo wokuguqula umjikelezo wezinwele ukusuka esigabeni se-telogen ukuya esigabeni se-anagen ...". Ngakho-ke ekuhlaziyweni okungu-1,000 kokukhishwe kwezitshalo, imbewu yamagilebhisi idlule kukho konke. Okuqukethwe okukhishwa kwembewu yamagilebhisi kanye nesizathu sazo sokuphumelela ekukhuleni kwezinwele kuqondiswa ngezinhlanganisela zayo ezihlukahlukene ze-phenolic, amandla e-antioxidant, ukujikeleza kwegazi okuthuthukisiwe, ukukhuthazwa kwe-collagen nezinye izinzuzo. (isifundo). Izinhlamvu zembewu yamagilebhisi zakha izinhlobonhlobo ze-oligomeric proanthocyanidins cishe ngo-3.1% we-PB-2 kuphela. Sifuna okuqukethwe okwengeziwe kwe-PB-2, ngakho okukhishwe kwembewu yamagilebhisi akunantshisekelo ekukhuleni kwentshebe (noma kunjalo kungase kube okokukhula kwezinwele).

Izinwele Epithelial Cell Effects

Ukuphetha mayelana nendlela yokukhula ekhuthaza imisebenzi yalawa ma-procyanidin, lolu cwaningo lubonise ukuthi i-procyanidin b-2 ibonise imiphumela ephezulu yokuthuthukisa ukukhula kwe-hair epithelial cell. Lokhu okutholakele kubika ukuthi i-procyanidin b-2 inomsebenzi wokuthuthukisa ukukhula kumaseli e-murine wezinwele ze-epithelial ngenani eliphakeme kakhulu le-300% ngokuhlobene nezilawuli kusiko losuku lwe-5, futhi ibonise ukuthi i-procyanidin oligomers ivuselela ukufakwa kwe-anagen ku-vivo murine. imodeli cishe umfutho ofanayo njengoba minoxidil 2%. I-Procyanidin b-2 igqame njenge-polyphenol ephezulu ekhuthaza ukukhula, uma iqhathaniswa ne-PB-3 ne-PC-1 (yingakho ukukhishwa kwembewu yamagilebhisi kungeke kube umthombo ongcono kakhulu wokukhula kwentshebe).

Kuyathakazelisa ukuqaphela ukuthi lolu cwaningo luhlole kuphela ukusetshenziswa kwezihloko zalawa ma-oligomers e-procyanidin ane-concentration engu-1%. Lolu cwaningo luqhathanise ukugxila kwalo okungu-1% kuphela ne-minoxidil engu-2%. Kungase kubekwe ukuthi ukuhlushwa okuphezulu (okufana no-5%) we-procyanidin b-2 kungase kuqhathaniswe kahle naleyo ye-Minoxidil engu-5%.

Lolu cwaningo lubonisa amandla athembisayo e-procyanidin b2 ukuze asetshenziswe njengesifaki sokukhula kwezinwele zemvelo.

Izivivinyo Zemitholampilo Yabantu

Lolu cwaningo lomtholampilo luphenye imiphumela ye-procyanidin b2 engu-1% kuphela ekukhuleni kwezinwele zomuntu ngemva kokusetshenziswa izinyanga ezingu-6. Ukuhlolwa komtholampilo okuyizimpumputhe okuphindwe kabili okubandakanya ingqikithi yezifundo ezingama-29 kwenziwa. Amadoda angu-19 eqenjini le-procyanidin B-2 namadoda angu-10 eqenjini lokulawula i-placebo ahlolwe. Ayikho imiphumela emibi ebonwe kunoma yiliphi iqembu.

Imiphumela:

Ukwanda kwenani lezinwele eziphelele endaweni ekhethiwe ye-scalp (0.5 cm square = 0.25 cm2 indawo) yezifundo zeqembu le-procyanidin B-2 ngemva kokuhlolwa kwezinyanga ezingu-6 kwakukhulu kakhulu kunezihloko zeqembu lokulawula i-placebo (i-procyanidin B-2 , 6.68 +/- 5.53 (isho +/- SD)/0.25 cm2; 0.08 +/- 4.56 (isho +/- SD)/0.25 cm2; Ukwanda kwenani lezinwele ezibulalayo, ezichazwa njengezinwele ezingaphezu kuka-60 microm ububanzi, endaweni ekhethiwe (0.5 cm square = 0.25 cm2 indawo) yezihloko zeqembu le-procyanidin B-2 ngemva kokuhlolwa kwezinyanga ezingu-6 kwakukhulu kakhulu. kunaleso sezihloko zeqembu lokulawula i-placebo (i-procyanidin B-2, 1.99 +/- 2.58 (isho +/- SD)/0.25 cm2; i-placebo, -0.82 +/- 3.40 (isho +/- SD)/0.25 cm2; P

Le miphumela iveza ukuthi amadoda asebenzisa i-PB2 abe nokwanda okukhulu kwenani lezinwele ezikhulile, inani lezinwele ezibulalayo, futhi ayikho imiphumela emibi ebikiwe.

Lapho abacwaningi beqhathanisa imiphumela yabo naleyo yemithi etholakalayo njengamanje, bathola ukuthi i-procyanidin B-2 ibangele ukukhula kwezinwele kancane kancane kune-minoxidil (ku-2%, hhayi i-5%), kodwa ukwanda okukhulu kwezinwele eziphelele kune-finasteride (Proscar). Ngokungafani nale mithi kadokotela, i-procyanidin B-2 ayizange ikhiqize imiphumela emibi. Ukwelashwa kwe-Procyanidin B-2 kukhombisa amandla njengekhambi eliphephile nelithembisayo lempandla yephethini yabesilisa.

Olunye ucwaningo lomtholampilo, olwathatha izinyanga eziyi-12, lwaphenya ukusebenza ngempumelelo kwama-oligomers e-apula procyanidin angu-0.7% (nakhona, ukugxila okuphansi impela nokho imiphumela yayisabalulekile).

Ukuhlolwa komtholampilo okuyizimpumputhe okuphindwe kabili okubandakanya ingqikithi yezifundo ze-43 kwenziwa. Amadoda angu-21 eqenjini le-procyanidin namadoda angu-22 eqenjini lokulawula i-placebo ahlaziywa. Ezinyangeni zokuqala ze-6, siqhathanise i-procyanidin namaqembu e-placebo ukuhlola imiphumela yokwelapha ye-procyanidin oligomers. Isikhathi sokufaka isicelo seqembu le-procyanidin sabe sesinwetshwa safinyelela ezinyangeni eziyi-12, futhi kwahlolwa isikhathi senani layo lokulungisa.

Ukwanda kwenani eliphelele lezinwele endaweni ekhethiwe ye-scalp yezihloko zeqembu le-procyanidin ngemva kokuhlolwa kwezinyanga ezingu-6 kwakukhulu kakhulu kunezihloko zeqembu lokulawula i-placebo (i-procyanidin, i-3.3 +/- 13.0 (isho +/- SD)/ 0.50 cm(2); -3.6 +/- 8.1/0.50 cm(2); Ukuthuthukiswa okuncike esikhathini esincike kusikhathi sokuminyana kwezinwele kwabonwa ezifundweni ze-procyanidin. Ayikho imiphumela emibi ebonwe kunoma yiziphi izifundo. Ngakho-ke ukwelashwa kwe-procyanidin kubonisa umsebenzi ongase ukhule izinwele.

I-Pharmacology & Pharmacokinetics ye-Procyanidin B-2

I-Pharmacology igatsha lezokwelapha eliphathelene nokusetshenziswa, imiphumela, kanye nezindlela zokwenza izidakamizwa.

I-Pharmacokinetics igatsha le-pharmacology eliphathelene nokuhamba kwezidakamizwa ngaphakathi komzimba.

Akubalulekile kuphela ukubheka nokuhlaziya izindlela zokwenza ze-PB-2, kubalulekile ukuqaphela ukuthi lesi sithako singamuncwa kanjani, singene, futhi sitholakale ngokwebhayoloji uma sisetshenziswa ngokwezihloko.

Lolu cwaningo luqaphele ukungena kwe-percutaneous kwe-PB2 e-lotion ene-0.0663mg kuphela. Imiphumela yabonisa ukuthi naphezu kokugxila okuphansi e-lotion, into yabonakala iwusizo mayelana ne-pharmacokinetics.

Ingqikithi yetiyori engu-4-5% ye-PB2 kufanele inikeze futhi ingene ngempumelelo, kodwa usokhemisi wezimonyo engimqashile uzongiqinisekisa uma lokhu kungenzeka.

Ingabe lokhu akunabo ubuthi futhi kuphephile ukusetshenziswa?

Ukuze kuhlolwe ukuphepha kwe-topical procyanidin B-2 njenge-ejenti ekhulisa izinwele, lolu cwaningo luhlole i-mutagenicity, umjovo we-acute subcutaneous, ukucasuka okuyinhloko, ukuzwela kwesikhumba, nokucasuka kwamehlo kwalesi sakhi. Imiphumela yabonisa ukuthi le nhlanganisela ayinazo imiphumela ye-mutagenic, ayinakho ukuchezuka kwesakhiwo, umthamo osemthethweni ungaphezu kuka-2000mg (umjovo ongaphansi kwesikhumba), akukho ukucasuka okuyinhloko phakathi kokuhlolwa onogwaja, kanye nokucasuka kancane lapho kufakwa emehlweni kanogwaja.

Izivivinyo zangaphambilini zomtholampilo kubantu nazo azizange zibonise imiphumela emibi emibi ebikiwe. Ucwaningo olushiwo ngaphambilini kumamodeli we-murine aluzange lubonise imiphumela emibi futhi.

Le miphumela iphakamisa ukuthi i-topical procyanidin b-2 iphephile futhi yamukelekile ukusetshenziswa.

Sengiphetha, i-Procyanidin B-2 inamandla amakhulu futhi ihlale ihlolwa ngezinzuzo zayo eziningi zezempilo. Ukuzibophezela kuka-Aogubio ekuthuthukiseni ama-nutraceuticals, izithasiselo kanye nemikhiqizo yezimboni ezihlukahlukene ezisebenzisa i-Procyanidin B-2 kugcizelela ukuzibophezela kwenkampani ekusebenziseni amandla ezinto zemvelo ukuthuthukisa impilo yabantu. Njengoba ucwaningo nokuqonda kwe-Procyanidin B-2 kuqhubeka nokuvela, kuyacaca ukuthi i-Procyanidin B-2 enamandla inesithembiso esihle ngekusasa lempilo yemvelo.

Miranda Zhang