Ukwembula Iqiniso Nge-Kojic Acid Dipalmitate kanye Nokusebenza kwayo
Ukwembula Iqiniso Nge-Kojic Acid Dipalmitate kanye Nokusebenza kwayo
I-Kojic acid dipalmitate, eyaziwa nangokuthi i-2-Palmitoylmethyl-5-palmitoyl-pyrone, iphuma ku-fat-soluble ye-kojic acid. Kuyisithako esisebenzayo esithole ukuthandwa embonini yezimonyo ngenxa yezindawo zayo ezicwebezelayo kanye ne-melanin-inhibiting. Kulesi sihloko, sizohlola ukusebenza kwe-kojic acid dipalmitate futhi sikhanyise izinzuzo zayo ezingaba khona esikhumbeni.
I-Aogubio, inkampani egxile ekukhiqizeni nasekusabalaliseni izinto ezisebenza ekhemisi, izinto zokusetshenziswa, okukhishwe kwezitshalo, kanye nokudla okunomsoco, ibe ngumkhiqizi ohamba phambili we-kojic acid dipalmitate. I-Aogubio izisungule embonini yemithi, yokudla, yezokudla okunempilo, nezimonyo ngokuhlinzeka ngemikhiqizo esezingeni eliphezulu ezosetshenziswa abantu. Ngobuchwepheshe nolwazi lwabo, i-Aogubio isebenzise ngempumelelo i-kojic acid dipalmitate ekukhiqizeni izimonyo, okuyenza ibe umthombo othembekile walesi sithako esinamandla.
I-Kojic acid, i-precursor ye-kojic acid dipalmitate, i-ejenti ehlanzayo ekhiqizwa isikhunta eziningana njenge-Aspergillus oryzae, i-Aspergillus parasiticus, ne-Aspergillus flavus. Itholakala nasekudleni okuvutshelwe njengesosi yesoya, ubhontshisi wesoya, newayini. AmaJapane abesebenzisa i-kojic acid amakhulu eminyaka ekukhiqizeni iwayini laseJapane elayisi, elaziwa ngokuthi "jiu koji." I-Japan isalokhu ingumkhiqizi oyinhloko we-kojic acid emhlabeni jikelele kusukela ngawo-1970.
Ukuhluka kwe-kojic acid dipalmitate kusekuzinzeni nasekusebenzeni kwayo ngempumelelo uma kuqhathaniswa ne-kojic acid yendabuko. I-Kojic acid yaziwa ngokungazinzi kwayo ekukhanyeni, ekushiseni, nasezinsimbini zensimbi, ezingaphazamisa ukusebenza kwayo kahle. Kodwa-ke, ngokwethulwa kwe-kojic acid dipalmitate, lezi ziphutha ziyanqotshwa. I-esterification yeqembu le-hydroxyl esebenzayo esakhiweni samangqamuzana e-kojic acid dipalmitate iyalivikela ekwenzeni amabhondi e-hydrogen nezinye izithako zezimonyo. Lokhu kuqinisekisa ukuthi ukusebenza kwezinye izithasiselo akuthinteki, okuvumela ukubambisana okungcono nezinye izinto zokusetshenziswa kwezimonyo.
Enye yezinzuzo eziyinhloko ze-kojic acid dipalmitate yikhono layo lokuvimbela ukwakheka kwe-melanin. I-Melanin inesibopho sobumnyama besikhumba, futhi ukukhiqizwa kwayo ngokweqile kungaholela ekukhanyeni kwebala kanye nethoni yesikhumba engalingani. Ngokuvimbela i-tyrosinase, i-enzyme ehilelekile ekukhiqizeni i-melanin, i-kojic acid dipalmitate isiza ukukhanyisa isikhumba futhi inciphise ukubukeka kwamabala amnyama namabala. Ukwakhiwa okuyingqayizivele kwe-kojic acid dipalmitate kuqinisekisa ukuthi umsebenzi wayo omuhle kakhulu uyagcinwa, unikeze imiphumela ephumelelayo yokukhanya kwesikhumba.
Ngaphezu kwalokho, i-kojic acid dipalmitate inikeza izakhiwo zokuthambisa, okuyenza ibe isithako esifanelekile sezimonyo. Ukuhambisana kwayo nezinye izinto zokusetshenziswa kwezimonyo kuyivumela ukuthi isebenze ngokubambisana, ilethe i-hydration esikhumbeni ngaphandle kokuphazamisa ukusebenza kwezinye izithasiselo. Lokhu kwenza i-kojic acid i-dipalmitate ibe isithako esisebenza ngezindlela eziningi esingagcini nje ngokukhazimulisa isikhumba kodwa futhi sisondle futhi sisinikeze amanzi, okuthuthukisa ibala elinempilo nelikhazimulayo.
Sengiphetha, i-kojic acid dipalmitate iyisithako esinamandla embonini yezimonyo, eyaziwa ngokukhazimula kwesikhumba kanye nezindawo ezivimbela i-melanin. I-Aogubio, inkampani ehloniphekile egxile ekukhiqizeni nasekusabalaliseni izinto ezisebenzayo nezinto zokusetshenziswa, ifake ngempumelelo i-kojic acid dipalmitate emikhiqizweni yabo yezimonyo. Ngokuzinza, ukusebenza kahle, kanye nezindawo zokuswakama, i-kojic acid dipalmitate inikeza isixazululo esihle kulabo abafuna ukuthuthukisa ukubukeka kwesikhumba sabo futhi bathole ibala elilinganayo.
Incazelo Yemikhiqizo
I-Kojic acid dipalmitate i-modified kojic acid derivative, engagcini nje ngokunqoba ukuntengantenga kokukhanya, ukushisa kanye ne-iron eyinsimbi, kodwa futhi igcina umsebenzi ovimbelayo we-tyrosinase futhi ivimbele ukwakheka kwe-melanin. I-Kojic dipalmitate ingumnikazi wendawo yamakhemikhali ezinzile. Ngeke ijike ibe phuzi uma isetshenziselwa i-oxidation, i-metallic ion, ukukhanya nokushisa.
Umsebenzi
- i-kojic acid dipalmitate iwuhlobo lwesivimbeli esikhethekile se-melanin. Ingavimbela umsebenzi we-tyrosinase ngokuhlanganiswa ne-ion yethusi kumaseli ngemva kokungena kumaseli esikhumba. I-Kojic acid nokuphuma kwayo kunomphumela ongcono wokuvimbela i-tyrosinase kunanoma iyiphi enye i-ejenti emhlophe yesikhumba.
- I-kojic acid dipalmitate ingaphinda iqede i-radical yamahhala, iqinise ukusebenza kwamaseli futhi igcine ukudla kukusha.
UKUHLAZIYWA OKUSISEKELO
| UHLAZIYO | INKCAZO | IMIPHUMELA |
| Ukubukeka | Impushana Emhlophe | Iyahambisana |
| Iphunga | Isici | Iyahambisana |
| Kunambithile | Isici | Iyahambisana |
| Isivivinyo | 99% | Iyahambisana |
| Sieve Analysis | I-100% idlula i-80 mesh | Iyahambisana |
| Ukulahlekelwa Ekumisweni | 5% Ubukhulu. | 1.02% |
| Umlotha one-sulphate | 5% Ubukhulu. | 1.3% |
| Khipha i-Solvent | I-Ethanol Namanzi | Iyahambisana |
| Insimbi Enzima | 5 ppm Max | Iyahambisana |
| Njengoba | 2ppm Max | Iyahambisana |
| Izincibilikisi Ezisele | 0.05% Ubukhulu. | Okubi |
| I-Microbiology | ||
| Inani Lepuleti Eliphelele | 1000/g Ubukhulu | Iyahambisana |
| Imvubelo & Isikhunta | 100/g Ubukhulu | Iyahambisana |
| E.Coli | Okubi | Iyahambisana |
| I-Salmonella | Okubi | Iyahambisana |
Izinhlelo zokusebenza
Ama-toner okunakekela umzimba/ubuso, izinto zokulwa nokuguga, ukuvikela ilanga, ngemva kokushona kwelanga nokuzishuka, ukucwenga kwesikhumba/ukukhanya, ukwelapha izimo ezihlukahlukene zesikhumba ezishintsha umbala obala noma iziyaluyalu, isb ama-solar lentigene, i-melasma, i-chloasma, izibazi, amabala, ubudala be-pigment nezinye izindawo zesikhumba ezinombala ogqamile
