Adenosine ni iki?

Adenosine ni nucleoside ibaho bisanzwe mu ngirabuzimafatizo zose z'umubiri. Muburyo bwa chimique ni 6-amino-9-beta-D-ribofuranosyl-9-H-purine.

Imiterere n'urwego rw'amaraso

Adenosine igizwe na adenine ifatanye na molekile isukari ya ribose (ribofuranose). Inkunga ifata adenine hamwe nisukari ya ribose yitwa β-N9-glycosidic.

Urwego rusanzwe rwa plasma adenosine ruri hagati ya 0.04 na 0.2 micromole.

Uruhare rwa physiologique na farumasi rwa Adenosine

Mu mubiri, adenosine ifasha mu guhererekanya ingufu za selile ikora molekile nka adenosine triphosphate (ATP) na adenosine diphosphate (ADP).

Adenosine igira kandi uruhare mu kwerekana inzira n'imikorere itandukanye mu mubiri ikora molekile zerekana ibimenyetso nka cyclic adenosine monophosphate (cAMP).

Adenosine mu bwonko

Mu bwonko adenosine ni inzitizi ya neurotransmitter. Ibi bivuze, adenosine irashobora gukora nka sisitemu yo hagati yo kwiheba. Mubihe bisanzwe, biteza ibitotsi kandi bigabanya kubyutsa. Iyo ukangutse urugero rwa adenosine mu bwonko ruzamuka buri saha.

Adenosine mu mutima

Mu mutima adenosine itera kwaguka kw'imiyoboro y'amaraso ya koronari ituma amaraso atembera mu mutima. Adenosine kandi yongerera diameter y'imiyoboro y'amaraso mu ngingo za periferiya.

Mu mutima adenosine igabanya umuvuduko wumutima kandi mumaraso igira ibikorwa byo kurwanya platine. Igikorwa cya antiplatelet kirinda platine guteranya hamwe na coagulation.

Adenosine mu maraso

Mu maraso adenosine isenywa na adenosine deaminase. Iyi misemburo iboneka mu ngirabuzimafatizo zitukura no ku rukuta rw'imitsi. Umuti Dipyridamole ni inzitizi ya enzyme adenosine deaminase bityo ikazamura urugero rwa adenosine mumaraso. Ibi bituma imiyoboro y'amaraso yaguka kandi ikagenda neza mu maraso binyuze mu mitsi y'amaraso itanga imitsi y'umutima.

Adenosine mu mpyiko, mu bihaha no mu mwijima

Mu mpyiko adenosine igabanya umuvuduko wamaraso yimpyiko kandi igabanya umusaruro wa rennin uva mumpyiko.

Mu bihaha bitera kugabanuka k'umuyaga no mu mwijima biganisha ku kugabanuka kw'imiyoboro y'amaraso kandi byongera gusenyuka kwa glycogene gukora glucose.

Adenosine ni ibintu bisanzwe bibaho bigira uruhare runini mubikorwa bitandukanye bya physiologique mumubiri wumuntu. Ni nucleoside, bivuze ko igizwe na molekile ya adenine ifitanye isano na molekile ya ribose. Adenosine iboneka mu ngirabuzimafatizo zose kandi igira uruhare mu guhererekanya ingufu nk'igice cya adenosine triphosphate (ATP), ifaranga ry'ibanze ry'ingirabuzimafatizo. Usibye uruhare rwayo muri metabolism yingufu, adenosine nayo ikora nka molekile yerekana ibimenyetso, ikora binyuze mubyakirwa byihariye mumubiri.

Kimwe mu bintu by'ingenzi bigize farumasi ya adenosine ni uburyo bwo gukora. Adenosine ikora ihuza reseptor ya adenosine yihariye, muri yo hakaba harimo ubwoko bune: A1, A2A, A2B, na A3. Buri isoform ihujwe nibikorwa bitandukanye bya physiologique hamwe ninzira zerekana inzira. Iyo adenosine ihuza abayakira, igenga imikorere itandukanye ya selile, harimo neurotransmission, tone y'amaraso, n'imikorere y'umubiri. Kurugero, gukora kwakirwa rya A1 birashobora gutuma umuntu abuza kurekura neurotransmitter, mugihe ibikorwa bya A2A byakira bishobora gutera vasodilasiyo ningaruka zo kurwanya inflammatory.

Gusobanukirwa na farumasi ya adenosine biganisha kumavuriro mubuvuzi butandukanye. Bumwe mu buryo buzwi bwo kuvura kwa adenosine ni uruhare rwayo mu kuvura indwara zimwe na zimwe z'umutima. Adenosine ikoreshwa nka antarrhythmic agent kubera ubushobozi bwayo bwo gutinda gutembera binyuze muri node ya atrioventricular, bityo igahagarika inzira igaruka kandi ikagarura injyana ya sinus isanzwe. Byongeye kandi, adenosine ikoreshwa nkibikoresho bya farumasi mubushakashatsi bwerekana amashusho yumutima kugirango hamenyekane parufe ya myocardial.

Muri make, adenosine ni molekile ifite impande nyinshi zikoreshwa mumavuriro menshi kubera imiterere ya farumasi nuburyo bwo gukora. Ubushobozi bwayo bwo guhindura imikorere ya selile binyuze mubikorwa byihariye bya reseptor bituma iba igikoresho cyingirakamaro mukuvura indwara zitandukanye zubuvuzi, kuva arititiyumu yumutima kugeza indwara zubuhumekero kimwe nibishobora gukoreshwa na neuroprotective. Mugihe ubushakashatsi kuri adenosine bukomeje, gukoresha amavuriro mashya kuri iyi molekile ishimishije birashobora gukomeza kugaragara, bikarushaho kwagura ubushobozi bwo kuvura mubuvuzi.

Pls mubaze neza Alisa kugirango ubone ibisobanuro birambuye ukoreshejekugurisha02@imaherb.com