Nicotinamide ni iki?

Nicotinamide ni iki?

Nikotinamide, izwi kandi nka niacinamide cyangwa aside aside ya nikotinike amide, ni amazi ashonga, akora vitamine B3. Byarushijeho kwigwa kubimenyetso byinshi bitandukanye murwego rwadermatology, ariko hakenewe ubushakashatsi bwinshi kugirango dusobanure agaciro kayo.

Nikotinamide isanzwe iboneka muke mumisemburo, inyama zinanutse, amafi, ibinyomoro n'ibinyamisogwe. Yongeyeho kandi kenshi mubinyampeke nibindi biribwa. Nicotinamide yo mu kanwa iraboneka nka 20-30 mg muri vitamine nyinshi, kandi ubwayo nkibinini 500-mg bihenze. Yinjijwe kandi muri benshiingingoibikoresho birimo izuba ryizuba hamwe nibikoresho byo kwisiga.

Nicotinamide ikora ite?

Ingaruka nini zamavuriro ya nicotinamide irashobora gusobanurwa ninshingano zayo nka:

• A.selireingufu zabanjirije
• Umuyobozi wainflammatory cytokine
• AninhibitorBya ikirimbuzi enzymepoly (adenosine diphosphate-ribose [ADP]) polymerase [PARP], igira uruhare runini muriADNgusana, kubungabunga genomic stabilite, hamwe na selile selile kubikomere birimogutwikanaapoptose(urupfu rw'akagari).

Niki nikotinamide ikoreshwa?

Vitamine B3 ni ngombwa ku buzima bwiza; kubura biganisha ku burwayi bukomeye, pellagra. Nicotinamide yo mu kanwa irashobora gukoreshwa neza mukuvura pellagra.

Nikotinamide ikoreshwa nkimiti irashobora kugirira akamaro uruhu muburyo butandukanye.

• Nikotinamide afiteanti-inflammatoryimitungo, ishobora gukoreshwa mukuvura indwara zifata (blisting).
• Irashobora kunoza acne mubikorwa byayo byo kurwanya inflammatory no kugabanya sebum.
• Irashobora kunoza imikorere yinzitizi yuruhu mukugabanya gutakaza amazi binyuze muriepidermis(uruhu rwinyuma) bityo byongera uruhu rwuruhu.
• Biravugwa kunoza isura, mugutezimberepigmentation, guhindagurika no gutukura uruhu rusaza; ikoreshwa muri bimwecosmeceuticalibicuruzwa.
• Irashobora kugabanya keratose ya actinic hamwe na kanseri y'uruhu, cyane cyane kanseri ya selile.
• Byakoreshejwe mu kuvura urumuri rwa polymorphique.

Imiterere yuruhu ivurwa na nikotinamide

• Nicotinamide

Bullous pemphigoid

Gukomatanya umunwa nicotinamide na tetracycline bigaragara ko ari ingirakamaro kuriSisitemusteroid mukuvura pemphigoid. Ni bikeuburozin'umutekano kuruta dapsone na prednisone.

Nibura byibuze igeragezwa rimwe ryamavuriro ugereranije no guhuza mg 500 za nikotinamide, inshuro eshatu kumunsi, na mg 500 za tetracycline inshuro enye kumunsi, hamwe na prednisone, mubarwayi 20 barwaye pemphigoide, habaye ibisubizo bitanu byuzuye nibisubizo bitanu byigice , mu itsinda rya nicotinamide na tetracycline ugereranije nigisubizo cyuzuye hamwe nibisubizo bitanu byigice mumatsinda ya prednisone, nyuma yibyumweru 8 bivurwa. Abarwayi bose uko ari batanu basubije mu itsinda rya nicotinamide na tetracycline bakomeje kutagira indwara mu gihe cyo gufata imiti mu gihe cy’amezi 10 yakurikiranwe, mu gihe abarwayi batatu bo mu itsinda rya prednisone bari barongeye kwibasirwa n'indwara hamwe no gufata steroid mu gihe kimwe.

Kanseri y'uruhu

Umwanya-igeragezwa ryagenzuwe ryagaragaje ko abarwayi bafite ibyago byinshi byangiza izuba bafata nicotinamide yo mu kanwa bafite keratose nini ya actinic na kanseri yo mu bwoko bwa kanseri yo mu bwoko bwa kanseri ishobora gutegereza kugabanuka kw'umubare mushyaibisebeigihe. Ibimenyetso ntibishoboka.

Ingaruka mbi zo munwa nicotinamide

Nicotinamide yo mu kanwa muri rusange yihanganirwa cyane muri dosiye munsi ya 3 g / kumunsi. Ntabwo itera guhindagurika cyangwa gastrointestinal guhagarika umutima, bitandukanye na aside ya nikotinike ibanziriza. Byavuzwe ko byongera ibyuya, kuzamura isukari mu maraso, no guterahypotension.

Umubare munini cyane wa nikotinamide urashobora gutera isesemi.

• Nicotinamide

Acne Nikotinamide, iboneka mumutwecream,gelnuburyo bwo munwa (urugero, Nicomide®), byagaragaye ko bifite akamaro mugukuraho acne. Mu isuzuma ry’amavuriro ryagenzuwe, gel ya nikotinamide 4% yasanze ifite akamaro nka antibiyotike yibanze ya 1% clindamycin gel mu kuvura acne vulgaris ku barwayi 76 bafite acne nkeya. Ubushakashatsi bwanzuye ko imiti igabanya ubukana bwa nikotinamide ishobora kuba yaragize uruhare mu gutsinda kwa acne. Nikotinamide igabanya kandi umusaruro wo mu maso.Sebumishinzwe kumurika mumaso kandi igira uruhare muri comedone zidacanwa no gukomeretsa acne. Ibyavuye mu igeragezwa ry’amavuriro ryagenzuwe neza mu bagore bo muri Caucase n’Abayapani ryerekanye ko gukoresha 2% nicotinamide moisturizer mu maso mu byumweru 4-6 bigabanya umusaruro wa sebum ufite itandukaniro rikomeye mu kumurika mu maso no mu mavuta.

Gel ya Nikotinamide igurishwa nka anKurengakuvura acne muri Kanada, Ositaraliya, NZ, Ubwongereza, Amerika na Irilande. Niba inshuro ebyiri-buri munsi zitera gukama cyane kuruhu, umuntu arashobora kugabanuka rimwe kumunsi, cyangwa undi munsi.

Rosacea

Ibimenyetso bya clinique nibimenyetso bya rosacea harimo kongera uruhu rwo mumaso rwumye, umutuku no kumva. Nibura byibuze ubushakashatsi bubiri, ubushakashatsi bwamazi burimo nicotinamide bwerekanwe kunoza imikorere yinzitizi yuruhu kubarwayi ba rosacea, bigatuma abantu batitabira neza.kurakaraharimo koza no kwisiga.

Nikotinamide ibanziriza nicotinamide adenine dinucleotide (NAD) na nicotinamide adenine dinucleotide fosifate (NADP), zifatanije-enzymes(abahugura baenzymatiquereaction) nibyingenzi munzira nyinshi zo guhinduranya. Iyi co-enzymes igira uruhare murimetabolismByaglucose, ingufu zituruka ku ngirabuzimafatizo, nasynthesisByalipide.Urwego rwa NADH / NADPH (uburyo bwagabanutse bwa NAD na NADP) bugabanuka uko imyaka igenda ishira hamwe nicotinamide yibanze bigaragara ko ihindura igabanuka. Mu bushakashatsi bwinshi bw’ubuvuzi, nicotinamide yibanze yateje imbere imirongo myiza n’iminkanyari, ibibara birenze urugero, ubururu butukura, hamwe no kutagira uruhu (umuhondo) kimwe na elastique. Ubushakashatsi bumwe bwerekanye nicotinamide kugirango yongere umusaruro wuruhu rwaceramide, aribintu byangiza umubiri kandi birinda uruhu, bityo bigatera imbere uruhu.

A.impumyi, umwanya-ugenzurwa, gutandukana-isura, ibumoso-iburyo,byateganijweUbushakashatsi bwibyumweru 12 ku bagore 50 bwasuzumye ingaruka za 5% nicotinamide yibanze ku bimenyetso bitandukanye byo gusaza kwuruhu. Abashakashatsi bavuze ko nicotinamide yibanze yatumye habaho iterambere ryinshi mumirongo myiza / iminkanyari, pigmentation, imiterere nubururu butukura. Ubushakashatsi bwatewe inkunga na Proctor na Gamble.

Ubundi bushakashatsi bwakozwe ku bagore 30 b'Abayapani bafite ubuzima bwiza bwatangaje ko bwateje imbere iminkanyari y'amaso nyuma y'ibyumweru umunani ukoresheje amavuta yo kwisiga arimo nikotinamide 4%.

Nikotinamide irihanganirwa neza kandi akenshi irashobora gukoreshwa nabadashobora kwihanganira retinoide yibanze cyangwa acide yimbuto.

Ingaruka za Anticancer

Imirasire ya Ultraviolet (UVR) nimpamvu nyamukuru itera kanseri y'uruhuiterambere.Uburyo UVR iganishakanseribiragoye harimo kwangiza ADN n'ingaruka kuri sisitemu yumubiri. Nikotinamide yerekanwe mu rwego rwo gusana ibyangiritse bya ADN byangiza kandi byangiza umubirikeratinocytesn'uruhu rw'umuntu. Ifite ubushobozi bwo gukumiraUV-Byizegukumira indwara, yerekanwe mubushakashatsi bwabakorerabushake bafite ikizamini cyiza cya Mantoux (ikizamini cyiza cya tuberculine). Imyitwarire ya Mantoux irashobora guhagarikwa no guhura na UVR. Nikotinamide yagabanije ubudahangarwa bw'umubiri igihe bwakoreshwaga mbere cyangwa nyuma yo guhura na UVR (bigereranya izuba).

Mu igeragezwa ry’amavuriro ryateguwe ku barwayi 50, 1% nikotinamide gel ikoreshwa inshuro ebyiri buri munsi ku mutwe, amaboko n'amaboko amezi atandatu byagabanijebivuzeumubare wamberekeratose ya actinic kuri 28%.

Nikotinamide ntabwo ikora nk'izuba (kandi ntirinda izuba). Ntabwo ifite antioxydeant, ariko irashobora kugira ingaruka kuri casade yuzuzanya, imbaraga za metabolisme selile, na apoptose (urupfu rw'utugingo).

Urupapuro rwemewe nisoko yemewe yamakuru yimiti, harimo imikoreshereze yemewe, dosiye, namakuru yumutekano. Reba urupapuro rwihariye mugihugu cyawe kugirango umenye amakuru yerekeye imiti.