PROCYANIDIN B-2 ni iki (yakuwe muri pome)？

Icyo ni ikihe?

Procyanidin B-2, ni agace ka flavonoide izwiho gukora antioxydants ikomeye, kuvura, no kurwanya inflammatory.

Izi mikorere ya polifenol, ikunze kuboneka muri pome, sayiri, nimbuto zinzabibu, basabwe gutanga umusaruro ukura kumisatsi mugutezimbere imisemburo ya epithelial selile no gutera intambwe igaragara yo gukura kwa anagen muburyo bwa vivo murine no mumezi 6 & 12 y'amavuriro ibigeragezo.

Inyungu zaPROCYANIDIN B-2

Ibikorwa byo gukumira iterambere rya catagen, gusenya ADN selile (apoptose), no guta umusatsi:

Ubu bushakashatsi bwasuzumye umubano wa Procyanidin b-2 n'inzira zerekana ibimenyetso bya TGF-beta, bizwiho gutera icyiciro cya catagen (aricyo cyiciro cyimisatsi igabanuka), hamwe na poroteyine ikora ya poroteyine kinase cascade (PKC), ifitanye isano na selile ikwirakwizwa. Ubu bushakashatsi bwongeyeho TGF-beta (1) na (2) ku mico y’imisatsi ya epiteliyale yimisatsi kandi inagaragaza ko izi nzira zigenda zigabanuka bitewe no gukura kwingirabuzimafatizo no gutera apoptose (apoptose nurupfu rwingirabuzimafatizo zibaho nkigice gisanzwe kandi kigenzurwa na an gukura kw'ibinyabuzima cyangwa iterambere). Ariko, kwiyongera kwa procyanidin B-2 mumico yimisatsi yimisatsi byatesheje agaciro izo ngaruka zibuza gukura kandi bikingira imisatsi umusatsi apoptose.

Hasuzumwe ibinyabuzima birenga 1.000 ...

Proanthocyanidine (harimo na procyanidin b-2) ikomoka ku mbuto z'imizabibu yavuzwe ko ari umusemburo kamere wo gukura umusatsi, nyuma yuko abahanga basuzumye amoko arenga 1.000 y'ibimera bivamo ibimera. Bavumbuye ko izo proanthocyanidine zagwije ingirabuzimafatizo zo mu misatsi ku mbeba ku kigero cya 230% ugereranije no kugenzura (100%) kandi zifite "igikorwa kidasanzwe cyo guhindura imisatsi kuva mu cyiciro cya telogene kugera mu cyiciro cya anagen ...". Mu isesengura rero 1.000 ku bikomoka ku bimera, imbuto zinzabibu zarabarushije zose. Ibiri mu mbuto zinzabibu nimpamvu yabyo yo gutsinda mumisatsi byahujwe binyuze mubintu bitandukanye bya fenolike, imbaraga za antioxydeant, kuzamura amaraso, kuzamura kolagen nibindi byiza. (kwiga). Imbuto zimbuto zinzabibu zigizwe na oligomeric proanthocyanidine hamwe na 3.1% gusa PB-2. Turashaka ibintu byinshi bya PB-2, bityo imbuto zinzabibu ntizishishikajwe no gukura ubwanwa (icyakora zishobora gukura kumisatsi).

Ingaruka zo Gukura Ingirabuzimafatizo

Kugira ngo dusoze ku buryo bwo gukura buteza imbere ibikorwa bya procyanidine, ubu bushakashatsi bwerekanye ko procyanidin b-2 yerekanye ingaruka nini ziteza imbere imikurire yimisatsi ya epiteliyale. Ubu bushakashatsi buvuga ko procyanidin b-2 ifite ibikorwa biteza imbere gukura mu ngirabuzimafatizo ya murine epithelia ku gipimo ntarengwa cya 300% ugereranije n’ubugenzuzi mu muco w’iminsi 5, kandi ikanagaragaza ko oligomers ya procyanidin itera kwinjiza anagen muri vivo murine. icyitegererezo hafi yingufu zingana na minoxidil 2%. Procyanidin b-2 yagaragaye cyane nka polifenol itera imbere cyane, ugereranije na PB-3 na PC-1 (niyo mpamvu imbuto y inzabibu itazaba isoko nziza yo gukura ubwanwa).

Birashimishije kumenya ko ubu bushakashatsi bwasuzumye gusa ikoreshwa ryibanze ryaba oligomeri ya procyanidin hamwe na 1% gusa. Ubu bushakashatsi bwagereranije gusa 1% yibanze hamwe na minoxidil 2%. Hashobora gutegurwa ko kwibanda cyane (nka 5%) bya procyanidin b-2 bishobora kugereranywa neza na Minoxidil 5%.

Ubu bushakashatsi bwerekana ubushobozi butanga procyanidin b2 gukoreshwa nkumusemburo wimisatsi usanzwe.

Ibigeragezo byubuvuzi byabantu

Igeragezwa ryamavuriro ryakoze iperereza ku ngaruka za 1% gusa ya procyanidin b2 ku mikurire yimisatsi yumuntu nyuma yo gukoreshwa amezi 6. Ikizamini cya kabiri-gihumye kivura kirimo amasomo 29 yose. Abagabo 19 bo mu itsinda rya procyanidin B-2 n’abagabo 10 bo mu itsinda rishinzwe kugenzura ibibanza byakorewe isesengura. Nta ngaruka mbi zagaragaye muri buri tsinda.

Ibisubizo:

Ubwiyongere bwimibare yimisatsi yose mugice cyagenwe cyagenwe (0,5 cm kare = 0,25 cm2 yubuso) bwibice byamatsinda ya procyanidin B-2 nyuma yikigeragezo cyamezi 6 cyari kinini cyane ugereranije n’amasomo agenzura amatsinda (procyanidin B-2 , 6.68 +/- 5.53 (bivuze +/- SD) / 0,25 cm2, umwanya wa 0.08 +/- 4.56 (bivuze +/- SD) / 0,25 cm2 P; Ubwiyongere bwimibare yimisatsi yanyuma, busobanurwa nkumusatsi urenga microm 60 zumurambararo, mumwanya wabigenewe (0,5 cm kare = 0,25 cm2 yubuso) bwibice byamatsinda ya procyanidin B-2 nyuma yikigeragezo cyamezi 6 byari byinshi cyane kurenza iy'itsinda rishinzwe kugenzura ibibanza (procyanidin B-2, 1.99 +/- 2.58 (bivuze +/- SD) / 0,25 cm2; umwanya, -0.82 +/- 3.40 (bivuze +/- SD) / 0,25 cm2; P;

Ibisubizo birerekana ko abagabo bakoresheje PB2 bariyongereye cyane mumisatsi yose yakuze, umubare wimisatsi yanyuma, kandi nta ngaruka mbi zavuzwe.

Igihe abashakashatsi bagereranije ibisubizo byabo n’imiti iboneka muri iki gihe, basanze procyanidin B-2 yateje imikurire mikeya ugereranije na minoxidil (kuri 2%, ntabwo ari 5%), ariko kwiyongera cyane kwimisatsi yose kuruta finasteride (Proscar). Bitandukanye niyi miti yandikiwe, procyanidin B-2 nta ngaruka mbi. Ubuvuzi bwa Procyanidin B-2 bwerekana ubushobozi nkumuti wizewe kandi utanga ikizere cyumusatsi wumugabo.

Ubundi bushakashatsi bw’amavuriro, bumaze amezi 12, bwakoze iperereza ku mikorere ya oligomeri ya pome ya 0.7% ya pome (nanone, kwibanda cyane ku buryo nyamara ibisubizo byari bikiri ngombwa).

Hakozwe ikizamini cya kabiri-gihumye kirimo amasomo 43 yose hamwe. Abagabo 21 bo mu itsinda rya procyanidin n'abagabo 22 bo mu itsinda rishinzwe kugenzura ibibanza byakorewe isesengura. Mu mezi 6 yambere, twagereranije procyanidin hamwe nitsinda rya placebo kugirango dusuzume ingaruka zubuvuzi bwa oligomers ya procyanidin. Igihe cyo gusaba cyitsinda rya procyanidin cyongerewe amezi 12, kandi hasuzumwe igihe cyagaciro kacyo cyo gukosora.

Ubwiyongere bwumubare wimisatsi mubice byagenwe byumutwe wibice byamatsinda ya procyanidin nyuma yikigeragezo cyamezi 6 byari byinshi cyane ugereranije nibyiciro byo kugenzura amatsinda (procyanidin, 3.3 +/- 13.0 (bivuze +/- SD) / 0,50 cm (2); Iterambere ryamasomo biterwa nubwinshi bwimisatsi byagaragaye mubisobanuro bya procyanidin. Nta ngaruka mbi zagaragaye muri imwe mu ngingo. Ubuvuzi bwa Procyanidin rero bwerekana ibikorwa bishobora gukura umusatsi.

Pharmacology & Pharmacokinetics ya Procyanidin B-2

Farumasi nishami ryubuvuzi ryita kumikoreshereze, ingaruka, nuburyo bwo gukora ibiyobyabwenge.

Pharmacokinetics nishami rya farumasi ishishikajwe no kugenda kwimiti mumubiri.

Ntabwo ari ngombwa gusa kureba no gusesengura uburyo bwibikorwa bya PB-2, ni ngombwa kureba uburyo iki kintu gishobora kwinjizwa, kwinjira, no kuboneka mubinyabuzima iyo bikoreshejwe hejuru.

Ubu bushakashatsi bwibanze ku kwinjira kwa PB2 mu mavuta yo kwisiga hamwe na 0.0663mg gusa. Ibisubizo byagaragaje ko nubwo amavuta yo kwisiga make, ibintu byagaragaye ko ari ingirakamaro mubijyanye na farumasi.

Kwibanda kuri 4-5% bya PB2 bigomba gutanga no gucengera neza, ariko chemiste cosmetic chemiste nahaye akazi azanyemeza niba ibi bishoboka.

Ibi ntabwo ari uburozi kandi bifite umutekano kubikoresha?

Kugira ngo hamenyekane umutekano wa procyanidin B-2 nkibikoresho bikura umusatsi, iyi studio yasuzumye mutagenicity, inshinge zikaze zo mu nda, guterwa ibanze, gukangurira uruhu, no kurwara amaso yuru ruganda. Ibisubizo byerekanye ko uru ruganda rudafite ingaruka za mutagenic, nta gukuramo imiterere, igipimo cyemewe kirenze 2000mg (inshinge zo mu nsi), nta kurakara kwambere mu bizamini byakorewe inkwavu, no kurakara gake iyo byinjijwe mumaso yurukwavu.

Igeragezwa ryambere ry’amavuriro ku bantu naryo ryerekanye ko nta ngaruka mbi zavuzwe. Ubushakashatsi bwavuzwe haruguru kuri modine ya murine bwerekanye ko nta ngaruka mbi nazo.

Ibisubizo byerekana ko procyanidin yibanze b-2 ifite umutekano kandi yemewe gukoreshwa.

Mu gusoza, Procyanidin B-2 ifite imbaraga nyinshi kandi ihora ishakishwa kubwinyungu nyinshi zubuzima. Ubwitange bwa Aogubio mu guteza imbere intungamubiri, inyongeramusaruro n’ibicuruzwa ku nganda zinyuranye ukoresheje Procyanidin B-2 bishimangira isosiyete yiyemeje gukoresha ingufu z’ibintu kamere mu kuzamura ubuzima bw’abantu. Mugihe ubushakashatsi no gusobanukirwa Procyanidin B-2 bikomeje kugenda bitera imbere, biragaragara ko Procyanidin B-2 ikomeye ifite amasezerano menshi yigihe kizaza cyubuzima busanzwe.

Miranda Zhang