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What is L-Ergothioneine?

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What is L-Ergothioneine?


Ergothioneine (ERG) is an unusual thio-histidine betaine amino acid that has potent antioxidant activities. It is synthesised by a variety of microbes, especially fungi (including in mushroom fruiting bodies) and actinobacteria, but is not synthesised by plants and animals who acquire it via the soil and their diet, respectively. Animals have evolved a highly selective transporter for it, known as solute carrier family 22, member 4 (SLC22A4) in humans, signifying its importance, and ERG may even have the status of a vitamin. ERG accumulates differentially in various tissues, according to their expression of SLC22A4, favouring those such as erythrocytes that may be subject to oxidative stress. Mushroom or ERG consumption seems to provide significant prevention against oxidative stress in a large variety of systems. ERG seems to have strong cytoprotective status, and its concentration is lowered in a number of chronic inflammatory diseases. It has been passed as safe by regulatory agencies, and may have value as a nutraceutical and antioxidant more generally.

Help slow the aging process by slowing the rate of telomere shortening

Provides effective cellular protection against oxidative stress

Supports vision, heart and overall cognitive health

Ergothioneine is a food-derived amino acid found in high concentrations in certain mushrooms. This amino acid has attracted the interest of the scientific community for its cytoprotective properties and favorable properties in supporting the healthy aging process.

Scientific basis:

Healthy Aging and Longevity

Research shows that ergothioneine can delay telomere shortening caused by oxidative stress.

Telomeres are like protective caps at the ends of chromosomes. Over time, these telomeres naturally shorten due to the aging process.  

In a preclinical study, L-ergothioneine was shown to protect telomere length and slow the rate of telomere shortening under conditions of oxidative stress, thereby supporting longevity. Cognitive and visual health Lower ergothioneine levels in older adults are associated with cognitive decline. In preclinical studies, ergothioneine has shown beneficial neuroprotective properties against oxidative stress and supports overall cognitive health.  The cytoprotective properties of ergothioneine have also been linked to vision health.

Supports Heart Health A 2020 clinical study found that higher levels of ergothioneine are associated with a healthier diet and heart health.

If you’re not a fan of mushrooms, you can still enjoy the life-promoting benefits of ergothioneine with L-ergothioneine. One capsule per day provides the equivalent of 2 to 5 cups of white mushrooms in L-ergothioneine.



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