Menene Adenosine?

Adenosine wani nucleoside ne wanda ke faruwa ta dabi'a a cikin dukkan sel na jiki. Kemikal shine 6-amino-9-beta-D-ribofuranosyl-9-H-purine.

Tsarin da matakan jini

Adenosine yana kunshe da adenine wanda aka makala a cikin kwayar ribose sugar molecule (ribofuranose). Haɗin da ke haɗa adenine da sukarin ribose ana kiransa β-N9-glycosidic bond.

Matsayin adenosine na plasma na yau da kullun yana tsakanin 0.04 da 0.2 micromoles.

Matsayin Physiological da Pharmacological na Adenosine

A cikin jiki, adenosine yana taimakawa wajen canja wurin makamashin salula ta hanyar samar da kwayoyin halitta kamar adenosine triphosphate (ATP) da adenosine diphosphate (ADP).

Adenosine kuma yana taka rawa wajen siginar hanyoyi da ayyuka daban-daban a cikin jiki ta hanyar samar da kwayoyin sigina kamar adenosine monophosphate na cyclic (cAMP).

Adenosine a cikin kwakwalwa

A cikin kwakwalwa adenosine ne mai hana neurotransmitter. Wannan yana nufin, adenosine na iya yin aiki a matsayin mai juyayi na tsakiya. A cikin yanayi na al'ada, yana inganta barci kuma yana hana motsa jiki. Lokacin tashi matakan adenosine a cikin kwakwalwa suna tashi kowace awa.

Adenosine a cikin zuciya

A cikin zuciya adenosine yana haifar da dilation na jijiyoyin jini na jijiyoyin jini wanda ke inganta yaduwar jini zuwa zuciya. Adenosine kuma yana ƙara diamita na tasoshin jini a cikin sassan sassan.

A cikin zuciya adenosine yana rage yawan bugun zuciya kuma a cikin jini yana da aikin anti-platelet. Ayyukan antiplatelet yana hana haɗuwar platelet da coagulation.

Adenosine a cikin jini

A cikin jini adenosine ya rushe ta hanyar adenosine deaminase. Wannan enzyme yana cikin jajayen sel da bangon jirgin ruwa. Magungunan Dipyridamole shine mai hana enzyme adenosine deaminase don haka yana haɓaka matakan adenosine a cikin jini. Wannan yana haifar da faɗuwar jijiyar jini da haɓakar jini ta hanyar jijiyoyin jini waɗanda ke ba da tsokar zuciya.

Adenosine a cikin koda, huhu da hanta

A cikin kodan adenosine yana rage kwararar jini na koda kuma yana rage samar da rennin daga kodan.

A cikin huhu yana haifar da takurewar hanyoyin iska kuma a cikin hanta yana haifar da takurewar tasoshin jini kuma yana ƙara rushewar glycogen don samar da glucose.

Adenosine wani fili ne da ke faruwa a zahiri wanda ke taka muhimmiyar rawa a cikin matakai daban-daban na ilimin lissafi a jikin mutum. Nucleoside ne, wanda ke nufin ya ƙunshi kwayar adenine da ke da alaƙa da kwayar ribose. Adenosine yana samuwa a cikin dukkan sel kuma yana shiga cikin canja wurin makamashi a matsayin wani bangare na adenosine triphosphate (ATP), kudin makamashi na farko na tantanin halitta. Baya ga rawar da yake takawa a cikin metabolism na makamashi, adenosine kuma yana aiki azaman siginar sigina, yana aiki ta takamaiman masu karɓa a cikin jiki.

Ɗaya daga cikin mahimman abubuwan da ake amfani da su na adenosine pharmacology shine tsarin aikin sa. Adenosine yana aiki da ɗaure ga takamaiman masu karɓar Adedo, wanda akwai substepes huɗu: A1, A2A, A2b, da A3b, da A2b, da A2b, da A2b, da A2b, da A2b, da A2b, da A2b, da A2b, da A2b, da A2b, da A3b, da A2b, da A2b, da A2b, da A3b, da A2b, da A2b, da A3b, da A2b, da A3b, da A2b, da A3b, da A2b, da A3b, da A2b, da A3b, da A2b, da A3b, da A3. Kowane isoform yana da alaƙa da ayyuka daban-daban na ilimin lissafi da hanyoyin sigina. Lokacin da adenosine ya ɗaure ga masu karɓar sa, yana daidaita nau'ikan hanyoyin salula, gami da neurotransmission, sautin jijiyoyin jini, da aikin rigakafi. Alal misali, kunna masu karɓa na A1 na iya haifar da hanawa na saki na neurotransmitter, yayin da kunna masu karɓar A2A zai iya haifar da vasodilation da anti-inflammatory effects.

Fahimtar ilimin harhada magunguna na adenosine yana haifar da aikace-aikacen asibiti a cikin saitunan likita iri-iri. Ɗaya daga cikin sanannun amfani da adenosine na asibiti shine rawar da yake takawa wajen magance wasu cututtuka na zuciya. Adenosine ana amfani da shi azaman wakili na antiarrhythmic saboda ikonsa na jinkirin gudanarwa ta kumburin atrioventricular, ta haka ne ya katse hanyar dawowa da dawo da motsin sinus na yau da kullun. Bugu da ƙari, ana amfani da adenosine azaman wakili na damuwa na harhada magunguna a cikin nazarin hoton zuciya don tantance bugun jini na zuciya.

A taƙaice, adenosine wani nau'in ƙwayar cuta ne mai yawa tare da amfani da yawa na asibiti saboda kaddarorin magunguna da tsarin aiki. Ƙarfinsa don daidaita tsarin salon salula ta hanyar takamaiman hulɗar masu karɓa ya sa ya zama kayan aiki mai mahimmanci wajen magance cututtuka daban-daban, daga arrhythmias na zuciya zuwa cututtuka na numfashi da kuma yiwuwar aikace-aikacen neuroprotective. Yayin da bincike kan adenosine ya ci gaba, sababbin amfani da asibiti don wannan kwayoyin halitta mai ban sha'awa na iya ci gaba da fitowa, yana kara fadada yiwuwar warkewa a magani.

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