Menene PROCYANIDIN B-2 (an ciro daga apples)?

Menene wancan?

Procyanidin B-2, wani yanki ne na flavonoids wanda aka sani don aiwatar da tasirin antioxidant mai ƙarfi, warkewa, da anti-mai kumburi.

Wadannan mahadi na polyphenol, waɗanda aka fi samu a cikin apples, sha'ir, da innabi tsaba, an ba da shawarar don samar da haɓakar haɓakar gashi ta hanyar haɓaka haɓakar gashi na epithelial cell girma da kuma haifar da lokacin haɓakar anagen mai aiki a cikin samfuran murine na vivo kuma a cikin watanni 6 & 12 na asibiti. gwaji.

AmfaninPROCYANIDIN B-2

Ayyuka na rigakafi akan ci gaban catagen, lalata DNA ta salula (apoptosis), da asarar gashi:

Wannan binciken yayi nazarin dangantakar Procyanidin b-2 zuwa hanyoyin siginar TGF-beta, wanda aka sani don haifar da lokaci na catagen (wanda shine matakin gashi mai lalacewa), da kuma mitogen-activated protein kinase cascade (PKC), wanda aka danganta da tantanin halitta. yaduwa. Wannan binciken ya kara da cewa TGF-beta (1) da (2) zuwa al'adun sel epithelial gashi kuma ya lura cewa waɗannan hanyoyin sun dogara da rage girman girma da kuma haifar da apoptosis (apoptosis shine mutuwar sel waɗanda ke faruwa a matsayin al'ada da sarrafawa ta wani yanki na al'ada. girma ko ci gaban kwayoyin halitta). Koyaya, ƙari na procyanidin B-2 zuwa al'adun sel gashi ya kawar da waɗannan tasirin hana haɓakawa kuma ya kare ƙwayoyin gashi daga apoptosis.

Sama da 1,000 na abubuwan halitta an bincika...

Proanthocyanidins (ciki har da procyanidin b-2) daga tsantsar inabi an lasafta shi a matsayin wani muhimmin tsantsa na halitta don girma gashi, bayan da masana kimiyya suka bincika sama da nau'ikan tsire-tsire iri iri 1,000. Sun gano cewa waɗannan proanthocyanidins sun haɓaka ƙwayoyin gashin gashi a cikin mice da kusan 230% dangane da sarrafawa (100%) kuma suna da "ayyukan canza salon gashi mai ban mamaki daga lokacin telogen zuwa lokacin anagen...". Don haka a cikin bincike guda 1,000 a kan tsantsar tsiro, 'ya'yan inabi sun mamaye su duka. Abubuwan da ke cikin ƙwayar inabi da kuma dalilinsu na samun nasara a ci gaban gashi ana yin sulhu ta hanyar mahaɗan phenolic daban-daban, ƙarfin antioxidant, ingantaccen yanayin jini, haɓaka collagen da sauran fa'idodi. (nazari). Ciwon innabi ya ƙunshi nau'ikan oligomeric proanthocyanidins tare da kusan 3.1% PB-2 kawai. Muna son ƙarin abun ciki na PB-2, don haka ruwan inabi ba su da sha'awar girma gemu (duk da haka suna iya zama don ci gaban gashi).

Hair Epithelial Growth Effects

Don kammalawa akan tsarin haɓaka ayyukan haɓaka haɓaka na waɗannan procyanidins, wannan binciken ya nuna cewa procyanidin b-2 ya nuna matsakaicin tasirin haɓaka haɓakar haɓakar gashi na epithelial cell. Wannan binciken ya ba da rahoton cewa procyanidin b-2 yana da aikin haɓaka haɓakawa a cikin sel gashi na epithelial na murine a matsakaicin mafi girman ƙimar 300% dangane da sarrafawa a cikin al'adar kwana 5, kuma sun nuna cewa procyanidin oligomers suna ƙarfafa shigar da anagen a cikin in vivo murine. samfurin a kusan irin ƙarfin da minoxidil 2%. Procyanidin b-2 ya tsaya a matsayin matsakaicin haɓakar haɓakar polyphenol, idan aka kwatanta da PB-3 da PC-1 (wanda shine dalilin da yasa tsantsa iri na innabi ba zai zama tushen mafi kyawun ci gaban gemu ba).

Yana da ban sha'awa a lura cewa wannan binciken ya yi nazari ne kawai game da aikace-aikacen waɗannan procyanidin oligomers tare da maida hankali 1% kawai. Wannan binciken kawai idan aka kwatanta da 1% maida hankali da minoxidil 2%. Ana iya ƙayyade cewa babban taro (kamar 5%) na procyanidin b-2 na iya kwatantawa da na Minoxidil 5%.

Wannan binciken yana nuna yuwuwar yuwuwar procyanidin b2 da za a yi amfani da shi azaman haifar da haɓakar gashi na halitta.

Gwajin Clinical na Dan Adam

Wannan gwaji na asibiti ya bincika sakamakon kawai 1% procyanidin b2 akan girman gashin ɗan adam bayan amfani da watanni 6. An yi gwajin asibiti mai makafi biyu wanda ya ƙunshi jimillar batutuwa 29. An yi nazarin maza 19 a cikin ƙungiyar procyanidin B-2 da maza 10 a cikin rukunin kula da placebo. Ba a sami wata illa ba a kowane rukuni.

Sakamako:

Ƙara yawan adadin gashin gashi a cikin yankin da aka keɓe (0.5 cm square = 0.25 cm2 area) na batutuwan rukuni na procyanidin B-2 bayan gwajin watanni 6 ya fi girma fiye da na batutuwan rukuni na placebo (procyanidin B-2). . Haɓakawa a cikin adadin gashin kai tsaye, waɗanda aka bayyana a matsayin gashin gashi fiye da 60 microm a diamita, a cikin yankin da aka keɓe (0.5 cm square = 0.25 cm2 area) na batutuwan rukuni na procyanidin B-2 bayan gwajin watanni 6 ya fi girma girma. fiye da na batutuwan ƙungiyar masu kula da placebo (procyanidin B-2, 1.99 +/- 2.58 (ma'anar +/- SD) / 0.25 cm2; placebo, -0.82 +/- 3.40 (ma'anar +/- SD) / 0.25 cm2; P

Wadannan sakamakon sun nuna cewa mazan da suka yi amfani da PB2 sun sami karuwa mai yawa a cikin jimlar gashin da suka girma, yawan gashin da aka yi amfani da su, kuma babu wani sakamako masu illa.

Lokacin da masu binciken suka kwatanta sakamakon su tare da magungunan da ake samuwa a halin yanzu, sun gano cewa procyanidin B-2 ya haifar da ƙananan gashi fiye da minoxidil (a 2%, ba 5%) ba, amma karuwa mafi girma a cikin gashin gashi fiye da finasteride (Proscar). Ba kamar waɗannan magungunan magani ba, procyanidin B-2 bai haifar da sakamako mai illa ba. Maganin Procyanidin B-2 yana nuna yuwuwar a matsayin amintaccen magani mai ban sha'awa ga gashin gashi.

Wani bincike na asibiti, wanda ya dade na watanni 12, ya binciki tasirin 0.7% apple procyanidin oligomers (sake, ƙananan maida hankali duk da haka sakamakon yana da mahimmanci).

An yi gwajin asibiti mai makafi biyu wanda ya ƙunshi jimillar batutuwa 43. Maza 21 a cikin ƙungiyar procyanidin da maza 22 a cikin ƙungiyar kula da placebo an yi nazari. A cikin watanni 6 na farko, mun kwatanta procyanidin da ƙungiyoyin placebo don tantance tasirin magani na procyanidin oligomers. Daga baya an tsawaita lokacin aikace-aikacen ƙungiyar procyanidin zuwa watanni 12, kuma an bincika lokacin ƙimar gyaran sa.

Haɓakawa a cikin jimlar yawan gashin gashi a cikin yanki da aka keɓe na batutuwan rukuni na procyanidin bayan gwajin watanni 6 ya fi girma fiye da na batutuwan ƙungiyar placebo (procyanidin, 3.3 +/- 13.0 (ma'anar +/- SD)/ 0.50 cm (2); placebo, -3.6 +/- 8.1 / 0.50 cm (2); An lura da haɓakar lokaci mai dogaro da ƙimar gashi a cikin batutuwa na procyanidin. Ba a sami wata illa ba a cikin kowane batutuwa. Maganin Procyanidin don haka yana nuna yuwuwar ayyukan girma gashi.

Pharmacology & Pharmacokinetics na Procyanidin B-2

Pharmacology reshe ne na likitanci wanda ya shafi amfani, tasiri, da kuma hanyoyin aiwatar da magunguna.

Pharmacokinetics shine reshe na ilimin harhada magunguna da ke damuwa da motsin ƙwayoyi a cikin jiki.

Ba wai kawai yana da mahimmanci a lura da nazarin hanyoyin aiwatar da PB-2 ba, yana da mahimmanci a lura da yadda za'a iya shawo kan wannan sinadari, shiga, da samuwa ta hanyar ilimin halitta idan an yi amfani da shi a saman.

Wannan binciken ya lura da shigar da PB2 a cikin ruwan shafa fuska tare da 0.0663mg kawai. Sakamakon ya nuna cewa duk da ƙananan maida hankali a cikin ruwan shafa fuska, abu ya tabbatar da amfani a game da pharmacokinetics.

Matsakaicin 4-5% maida hankali na PB2 yakamata ya ba da kuma shiga cikin inganci, amma masanin kimiyyar kwaskwarima na hayar zai tabbatar min idan hakan zai yiwu.

Shin wannan ba mai guba bane kuma mai lafiya don amfani?

Don kimanta amincin procyanidin B-2 a matsayin wakili mai girma gashi, wannan binciken yayi nazarin mutagenicity, m allurar subcutaneous, hangula na farko, fahimtar fata, da haushin ido na wannan fili. Sakamakon ya nuna wannan fili ba shi da wani tasiri na mutagenic, babu ɓarna na tsari, kashi na shari'a ya fi 2000mg (allurar subcutaneous), babu fushi na farko tsakanin gwaje-gwaje akan zomaye, da ɗan haushi lokacin da aka saka cikin idanun zomo.

Gwaje-gwajen da aka yi a asibiti a baya akan mutane kuma ba su nuna wani mummunan sakamako da aka ruwaito ba. Nazarin da aka ambata a baya akan ƙirar murine bai nuna wani tasiri mai tasiri ba.

Wadannan sakamakon suna nuna cewa procyanidin b-2 na Topical yana da aminci kuma an yarda da amfani.

A ƙarshe, Procyanidin B-2 yana da babban tasiri kuma ana bincikarsa akai-akai don fa'idodin kiwon lafiya da yawa. Ƙaddamar da Aogubio don haɓaka abubuwan gina jiki, kari da samfurori don masana'antu daban-daban ta amfani da Procyanidin B-2 yana jaddada ƙaddamar da kamfanin don yin amfani da ikon abubuwan halitta don inganta lafiyar ɗan adam. Kamar yadda bincike da fahimtar Procyanidin B-2 ke ci gaba da haɓakawa, a bayyane yake cewa Procyanidin B-2 mai ƙarfi yana da babban alkawari ga makomar lafiyar halitta.

Miranda Zhang