Pankhani ya thanzi ndi thanzi, kupeza zowonjezera zowonjezera kungapangitse kusiyana kwakukulu. Keira akuwuzani za resveratrol mu positi lero. Resveratrol ndi yotchuka padziko lonse lapansi chifukwa cha French Paradox yomwe inakambidwa m'zaka za m'ma 1990, pamene amakhulupirira kuti chifukwa chomwe anthu a ku France amadya zakudya zamafuta ambiri sakhala ndi matenda a mtima ndi chifukwa chakuti resveratrol ili mu vinyo wofiira omwe amamwa nthawi zambiri. .
Kuyambira nthawi imeneyo, resveratrol yakhala ikudziwika chifukwa cha ubwino wake wathanzi, kuphatikizapo antioxidant, anti-inflammatory, anticancer, ndi zotsatira zotetezera mtima.
Kodi resveratrol ndi chiyani?
Resveratrol, non-flavonoid polyphenol organic compound, ndi antitoxin yopangidwa ndi zomera zambiri pamene ilimbikitsidwa, ndi mankhwala a C14H12O3. Mu 1940, katswiri wa ku Japan MichioTakaoka anayamba kudzipatula resveratrol ku Veratrum album mu banja la kakombo, ndipo kenako anaipeza Polygonum cuspidatum mu polygonum banja mu 1963. Ikhoza kupangidwa mu masamba mphesa ndi zikopa mphesa ndipo ndi bioactive pophika vinyo ndi madzi a mphesa. Imatengeka mosavuta m'kamwa ndikutuluka mumkodzo ndi chopondapo pambuyo pa metabolism. Kuyesa kwa in vitro ndi nyama kwawonetsa kuti resveratrol ili ndi antioxidant, anti-yotupa, anticancer ndi zotsatira zoteteza mtima.
Resveratrolimafalitsidwa kwambiri muzomera, ndipo kuyambira 2021, yapezeka mu zomera zoposa 70 kuchokera ku mabanja 21, Makamaka, itis yomwe imapezeka ku Vitis, Ampelopsis, Polygonum, Arachis, Cassia, Sophora, Veratrum, Veratrum ndi Eucalyptus. Zomera zodziwika bwino zomwe zimakhala ndi resveratrol zimaphatikizapo mphesa, knotweed, mtedza, cassia, etc. Njira yopangira mankhwala a resveratrol ndi njira yosavuta komanso yokhwima, zokolola zamtengo wapatali komanso mtengo wotsika mtengo wagwiritsidwa ntchito pokonzekera misala ya mafakitale, kotero kuti kupeza resveratrol sikunali kokwanira. motalika zimadalira m'zigawo ndi kulekana ndi zomera. Kaphatikizidwe ka resveratrol makamaka amagwiritsa ntchito Wittig reaction kuti azindikire kuphatikizika kwa mphete ziwiri za benzene, ndipo zokolola zimatha kupitilira 50%.
Kodi zotsatira za resveratrol ndi chiyani?
- Anti-kukalamba
M'zaka zaposachedwa, zapezeka kuti ma polyphenols ambiri ali ndi anti-oxidation komanso anti-free radical effects.
Monga antioxidant yachilengedwe, resveratrol imakhala ndi mphamvu yodzichotsa yokha komanso anti-lipid peroxidation, komanso poyerekeza ndi ma antioxidants achikhalidwe monga vitamini C, butylhydroxytoluene, tocopherol, resveratrol imakhala ndi antioxidant effect.
Resveratrolimakhala ndi antioxidant zotsatira zake makamaka kudzera mukusaka kapena kuletsa ma free radicals, kuletsa lipid peroxidation, kuwongolera zochita za michere yokhudzana ndi antioxidation ndi njira zina.
Resveratrol imakana kukalamba komwe kumachitika chifukwa cha lipid peroxidation chifukwa cha ma free radicals ndi metabolites awo. Nthawi yomweyo, resveratrol imachotsa ma free radicals, imachepetsa zomwe zili mu H₂O₂ pakhungu, imathandizira ntchito ya ATPase, motero imakhala ndi zotsatira zochedwetsa ukalamba wa khungu.
- Lamulirani shuga wamagazi
Matenda a shuga ndi matenda ofala kwambiri, komanso omwe amapewa mosavuta, koma chifukwa cha izi nthawi zambiri amalola kuti anthu azitenga mopepuka, vuto la matenda a shuga, ndi arteriosclerosis, komanso kuwonjezera kwambiri mwayi wa myocardial infarction, sitiroko, ngati zimakhudzanso ma microvessels a impso, zimayambitsanso kulephera kwa impso, kotero momwe mungachepetsere shuga m'magazi ndikofunikira kwambiri pamoyo.
Mu phunziro laling'ono, resveratrol (150 mg tsiku kwa masiku 30, DSM proprietary component resVida) imapangitsa kuti shuga ya magazi (ndi 4.2%) ikhale yabwino komanso ma insulini (ndi 13.7%) mwa anthu onenepa kwambiri.
- Anti-chotupa, anti-cancer
Resveratrol imalepheretsa kwambiri hepatocellular carcinoma, khansa ya m'mawere, khansa ya m'matumbo, khansa ya m'mimba, khansa ya m'magazi ndi ma cell ena otupa. Akatswiri ena atsimikizira kuti resveratrol imakhala ndi zotsatira zoonekeratu zolepheretsa maselo a melanoma pogwiritsa ntchito njira ya MTT ndi cytometry yoyenda.
Zanenedwa kuti resveratrol imatha kupititsa patsogolo chithandizo cha radiation ya khansa, kusewera "1+1> 2" zotsatira, ndikulepheretsa bwino ntchito ya maselo a khansa. Koma mpaka pano, chifukwa cha zovuta zamakina odana ndi chotupa a resveratrol, ofufuza sanafikire mgwirizano pamachitidwe ake.
- Ntchito zina
Resveratrol imakhalanso ndi antibacterial, antioxidant, immunomodulatory, antiasthmatic ndi zina zamoyo. Resveratrol imafunidwa kwambiri chifukwa cha ntchito zake zosiyanasiyana zamoyo.
Momwe mungatulutsire resveratrol?
- Natural zomera m'zigawo njira
Resveratrol adachotsedwa ndikuyeretsedwa ku mphesa, knotweed ndi mtedza. The zosakhwima m'zigawo luso makamaka zikuphatikizapo organic zosungunulira m'zigawo njira, alkali m'zigawo njira ndi enzyme m'zigawo njira, mayikirowevu anathandiza m'zigawo njira, CO2 supercritical m'zigawo, akupanga anathandiza m'zigawo ndi njira zina zatsopano amagwiritsidwanso ntchito. Cholinga chachikulu cha kuyeretsedwa ndikulekanitsa resveratrol cis, trans isomer ndi resveratrol Xib kuchokera ku resveratrol yaiwisi yotengedwa kuti apeze trans-resveratrol. Njira zoyeretsera zomwe zimagwiritsidwa ntchito kwambiri ndi chromatography, silica gel column chromatography, thin layer chromatography, high performance liquid chromatography ndi zina zotero.
- Synthesis njira
Chifukwa cha kuchepa kwa resveratrol muzomera komanso mtengo wokwera kwambiri, kugwiritsa ntchito mankhwala, biological and genetic engineering njira zopezera resveratrol kwakhala njira yofunikira kwambiri pakukula. Perkin reaction, Hech reaction ndi Witting-Hormer reaction ndi okhwima mankhwala njira kaphatikizidwe wa resveratrol, ndi zokolola za 55.2%, 70% ndi 35.7%, motero. Kugwiritsa ntchito ukadaulo wopanga ma genetic kuwongolera kapena kukonza njira ya biosynthesis ya resveratrol kuti mupeze mizere yokolola kwambiri; Zokolola za resveratrol zinawonjezeka ndi 1.5 ~ 3.0 nthawi ndi mutagenesis ndi njira zina.
Aogubio ndi kampani yomwe imagwira ntchito yopanga ndi kugawa zinthu zomwe zimagwira ntchito pamankhwala, zopangira ndi zopangira mbewu, kuphatikiza zakudya zopatsa thanzi popanga zowonjezera za anthu. Timayang'ana kwambiri za mankhwala ndi mankhwala kwa mafakitale ogulitsa mankhwala, chakudya, zakudya zopatsa thanzi komanso zodzikongoletsera, ndipo tadzipereka kupereka makasitomala apamwamba komanso othandiza.
CHITSIMIKIZO CHADONGOSOLO:
Malo athu ali ndi labotale yogwiritsira ntchito chromatography yamakono ya gasi kuyesa mwamphamvu chiyero ndi mphamvu za zipangizo zathu; kuwonetsetsa kuti makasitomala athu amalandira zinthu zabwino kwambiri nthawi zonse.
THANDIZO LAMAKASITOMALA:
Kusunga cholinga chathu chokwaniritsa Ndondomeko Yotsimikizira Kukhutitsidwa, gulu lathu lodzipereka nthawi zonse limakhala lokonzeka kupatsa aliyense wa makasitomala athu ndi makampani omwe amatsogolera makasitomala pamagawo onse a dongosolo.
Ngati mukufuna kudziwa kapena kugula resveratrol yapamwamba kwambiri, lemberani kayla.
Contact: Keira Zhang
Imelo: sales06@aogubio.com
Tel: +86 18066856327
Nthawi yotumiza: Jan-08-2024
