Uma kukhulunywa ngempilo nokuphila kahle, ukuthola izithasiselo ezifanele kungenza umehluko omkhulu. U-Keira uzokutshela mayelana ne-resveratrol kulokhu okuthunyelwe namuhla. I-Resveratrol idume emhlabeni wonke ngenxa ye-French Paradox okwaxoxwa ngayo ngeminyaka yawo-1990, lapho kwakunenkolelo yokuthi isizathu esenza abantu baseFrance abadla ukudla okunamafutha amaningi bangabi sengozini yesifo senhliziyo kungenxa yokuthi i-resveratrol iqukethe iwayini elibomvu abavame ukuliphuza. .
Kusukela lapho, i-resveratrol iqhubekile nokutholwa ngezinzuzo zayo zezempilo ezingaba khona, okuhlanganisa i-antioxidant, anti-inflammatory, anticancer, kanye nemiphumela yokuvikela inhliziyo.
Iyini i-resveratrol?
I-Resveratrol, inhlanganisela ye-polyphenol engeyona i-flavonoid ye-organic, iyi-antitoxin ekhiqizwa izitshalo eziningi lapho ivuselelwa, ne-chemical formula C14H12O3. Ngo-1940, isazi saseJapane u-MichioTakaoka saqala sahlukanisa i-resveratrol ku-albhamu ye-Veratrum emndenini we-lily, futhi kamuva sayithola ku-Polygonum cuspidatum emndenini we-polygonum ngo-1963. Ingahlanganiswa ngamahlamvu amagilebhisi nezikhumba zamagilebhisi futhi iyisithako esisebenzayo ewayinini nase ijusi yamagilebhisi. Imuncwa kalula ngomlomo futhi ikhishwe emchamweni nasesigqikini ngemva kokumenyezelwa kwe-metabolism. Ukuhlolwa kwe-in vitro nezilwane kubonise ukuthi i-resveratrol ine-antioxidant, anti-inflammatory, anticancer kanye nemiphumela yokuvikela yenhliziyo.
I-Resveratrolisakazwa kabanzi ezitshalweni, futhi kusukela ngo-2021, itholakale ezitshalweni ezingaphezu kuka-70 ezivela emindenini engu-21, Ikakhulukazi, i-itis etholakala ku-Vitis, Ampelopsis, Polygonum, Arachis, Cassia, Sophora, Veratrum, Veratrum kanye ne-Eucalyptus. Izitshalo ezijwayelekile eziqukethe i-resveratrol zifaka amagilebhisi, ama-knotweed, amakinati, i-cassia, njll. Indlela yokuhlanganiswa kwamakhemikhali ye-resveratrol enenqubo elula nevuthiwe, isivuno esikhulu somkhiqizo kanye nezindleko eziphansi zokukhiqiza kusetshenziswe ukulungiswa kwenqwaba yezimboni, ukuze ukutholwa kwe-resveratrol akukho. isikhathi eside kuncike ekukhishweni nasekuhlukaneni nezitshalo. Inqubo yokuhlanganisa ye-resveratrol ikakhulukazi isebenzisa ukusabela kwe-Wittig ukuze ibone ukuhlanganisa izindandatho ezimbili ze-benzene, futhi isivuno singafinyelela ngaphezu kuka-50%.
Iyini imiphumela ye-resveratrol?
- Anti-ukuguga
Eminyakeni yamuva nje, kutholakale ukuthi ama-polyphenol amaningi ane-anti-oxidation ebalulekile kanye nemiphumela ephikisana namahhala.
Njenge-antioxidant yemvelo, i-resveratrol inokuziqeda okuqinile kanye ne-anti-lipid peroxidation, futhi iqhathaniswa nama-antioxidants endabuko afana ne-vitamin C, i-butylhydroxytoluene, i-tocopherol, i-resveratrol inomphumela ongcono we-antioxidant.
I-Resveratrolisebenzisa umphumela wayo we-antioxidant ikakhulukazi ngokukhipha noma ukuvimbela ama-radicals mahhala, ukuvimbela i-lipid peroxidation, ilawula umsebenzi wama-enzyme ahlobene ne-antioxidation nezinye izindlela.
I-resveratrol imelana nokuguga okubangelwa i-lipid peroxidation ebangelwa ama-radicals mahhala kanye nama-metabolites awo. Ngesikhathi esifanayo, i-resveratrol isusa ama-radicals mahhala, inciphisa okuqukethwe kwe-H₂O₂ esikhumbeni, ithuthukise umsebenzi we-ATPase, futhi ngaleyo ndlela ibe nomthelela wokubambezela ukuguga kwesikhumba.
- Lawula ushukela wegazi
Isifo sikashukela yisifo esivame kakhulu esingamahlalakhona, kodwa futhi yisona esivinjelwa kalula, kodwa ngenxa yalokhu ngokuvamile ake abantu bakuthathe kalula, inkinga yesifo sikashukela, i-arteriosclerosis, ngaphezu kokwandisa kakhulu amathuba okuba ne-myocardial infarction, unhlangothi, uma kuthinta imithambo yezinso, kuzodala ukwehluleka kwezinso, ngakho-ke indlela yokulawula ushukela wegazi ibalulekile empilweni.
Ocwaningweni oluncane, i-resveratrol (150 mg nsuku zonke ngezinsuku ze-30, i-DSM proprietary component resVida) ithuthukise amazinga kashukela egazini (ngo-4.2%) kanye namazinga e-insulin (ngo-13.7%) kubantu abakhuluphele ngokweqile.
- I-anti-tumor, anti-cancer
I-Resveratrol inomphumela omkhulu wokuvimbela i-hepatocellular carcinoma, umdlavuza webele, umdlavuza wekoloni, umdlavuza wesisu, i-leukemia namanye amaseli wesimila. Ezinye izazi ziye zaqinisekisa ukuthi i-resveratrol inomphumela osobala wokuvimbela kumaseli e-melanoma ngendlela ye-MTT kanye ne-cytometry yokugeleza.
Kubikwe ukuthi i-resveratrol ingathuthukisa ukwelapha ngemisebe yomdlavuza, idlale umphumela we-"1+1>2", futhi ivimbele ngempumelelo indima yamaseli omdlavuza. Kodwa kuze kube manje, ngenxa yobunzima be-anti-tumor mechanism ye-resveratrol, abacwaningi abakafinyeleli ukuvumelana ngendlela yayo yokusebenza.
- Eminye imisebenzi
I-Resveratrol nayo ine-antibacterial, antioxidant, immunomodulatory, antiasthmatic kanye neminye imisebenzi yezinto eziphilayo. I-Resveratrol ifunwa kakhulu ngenxa yemisebenzi yayo ehlukahlukene yezinto eziphilayo.
Indlela yokukhipha i-resveratrol?
- Indlela yokukhipha izitshalo zemvelo
I-Resveratrol yakhishwa futhi yahlanzwa emvinini, i-knotweed ne-peanut. Ubuchwepheshe bokukhishwa okungahluziwe ikakhulukazi buhlanganisa indlela yokukhipha i-solvent ephilayo, indlela yokukhipha i-alkali kanye nendlela yokukhipha i-enzyme, indlela yokukhipha i-microwave esiza, i-CO2 isizinda esiphezulu, isizinda esisizwa yi-ultrasonic nezinye izindlela ezintsha nazo zisetshenziswa. Injongo eyinhloko yokuhlanza iwukuhlukanisa i-resveratrol cis, i-trans isomer ne-resveratrol Xib kusukela ku-resveratrol eluhlaza ekhishiwe ukuze kutholwe i-trans-resveratrol. Izindlela zokuhlanza ezivame ukusetshenziswa yi-chromatography, i-silica gel column chromatography, i-chromatography yongqimba oluncane, ukusebenza okuphezulu kwe-chromatography ye-liquid nokunye.
- Indlela yokuhlanganisa
Ngenxa yokuqukethwe okuphansi kwe-resveratrol ezitshalweni kanye nezindleko eziphezulu zokukhipha, ukusetshenziswa kwamakhemikhali, izindlela zebhayoloji kanye nobunjiniyela bezakhi zofuzo ukuthola i-resveratrol sekuyindlela ebaluleke kakhulu ekuthuthukisweni. Ukusabela kwe-Perkin, ukusabela kwe-Hech kanye nokusabela kwe-Witting-Hormer izindlela zamakhemikhali ezivuthiwe zokuhlanganiswa kwe-resveratrol, ngesivuno esingu-55.2%, 70% kanye no-35.7%, ngokulandelana. Ukusebenzisa ubuchwepheshe bobunjiniyela bofuzo ukulawula noma ukuthuthukisa indlela ye-biosynthesis ye-resveratrol ukuze uthole imigqa yezitshalo enesivuno esikhulu; Isivuno se-resveratrol sanda izikhathi ze-1.5 ~ 3.0 nge-mutagenesis nezinye izindlela.
I-Aogubio yinkampani esebenza ngokukhethekile ekukhiqizeni nasekusabalaliseni izinto ezisebenza ekhemisi, izinto ezingavuthiwe nezikhishiwe zezitshalo, okuhlanganisa nezakhamzimba zokukhiqiza izithasiselo zabantu. Sigxila emithini nemikhiqizo yezimboni zemithi, zokudla, ezomsoco nezimonyo, futhi sizibophezele ekunikezeni amakhasimende izithasiselo ezisezingeni eliphezulu nezisebenzayo.I-Resveratrol ingenye yezithako esizihlinzekayo ekukhishweni kwezitshalo.
UKUQINISEKISA IKHWALITHI:
Indawo yethu ifakwe ilabhorethri esebenzisa i-state-of-the-art gas chromatography ukuze ihlole ngokuqinile ubumsulwa namandla ezinto zethu zokusetshenziswa; ukuqinisekisa ukuthi amakhasimende ethu athola imikhiqizo esezingeni eliphezulu ngaso sonke isikhathi.
INSIZAKALO YEKHASIMENDE:
Ukugcina umgomo wethu wokugcwalisa Inqubomgomo Yesiqinisekiso Sokwaneliseka, ithimba lethu elizinikele lihlale likulungele ukunikeza ikhasimende ngalinye ngenkonzo yamakhasimende ehamba phambili embonini kuzo zonke izici ze-oda.
Uma ufuna ukwazi noma ukuthenga ikhwalithi ephezulu ye-resveratrol, sicela uxhumane no-kayla.
Oxhumana naye: Keira Zhang
I-imeyili: sales06@aogubio.com
Ucingo: +86 18066856327
Isikhathi sokuthumela: Jan-08-2024
