Ku bijyanye n'ubuzima no kumererwa neza, kubona inyongera zikwiye birashobora guhindura isi itandukanye. Keira agiye kukubwira ibya resveratrol muriyi nyandiko uyumunsi. Resveratrol izwi cyane ku isi kubera Paradox y'Abafaransa yaganiriweho mu myaka ya za 90, igihe byemerwaga ko impamvu Abafaransa barya ibiryo birimo amavuta menshi badakunda kwandura indwara z'umutima n'imitsi ni uko resveratrol iba muri vino itukura bakunze kunywa .
Kuva icyo gihe, resveratrol yakomeje kuvumburwa kubera ingaruka zishobora guteza ubuzima, harimo antioxydeant, anti-inflammatory, anticancer, n'ingaruka zo gukingira umutima.
Resveratrol ni iki?
Resveratrol, ifumbire mvaruganda idafite flavonoide polifenol, ni antitoxine ikorwa nibimera byinshi iyo ikangutse, hamwe na formula ya chimique C14H12O3. Mu 1940, intiti y’Ubuyapani MichioTakaoka yabanje gutandukanya resveratrol na alubumu ya Veratrum mu muryango wa lili, nyuma ayikura muri Polygonum cuspidatum mu muryango wa polygonum mu 1963. Irashobora guhurizwa mu mababi yinzabibu n’uruhu rwinzabibu kandi ni bioaktique muri vino na divayi. umutobe w'inzabibu. Byoroshye kwinjizwa mumunwa bigasohoka mu nkari no kuntebe nyuma ya metabolism. Mu bushakashatsi bwa vitro n’inyamaswa bwerekanye ko resveratrol ifite antioxydants, anti-inflammatory, anticancer ningaruka zo gukingira umutima.
Resveratrolikwirakwizwa cyane mu bimera, kandi guhera mu 2021, yabonetse mu bimera birenga 70 byo mu miryango 21, By'umwihariko, itis iboneka muri Vitis, Ampelopsis, Polygonum, Arachis, Cassia, Sophora, Veratrum, Veratrum na Eucalyptus. Ibihingwa bisanzwe birimo resveratrol birimo inzabibu, ipfundo, ibishyimbo, ibinyomoro, cassia, nibindi. Uburyo bwa synthesis ya chimique ya resveratrol hamwe nibikorwa byoroshye kandi bikuze, umusaruro mwinshi hamwe nigiciro cyumusaruro muke wakoreshejwe mugutegura inganda, kuburyo kugura resveratrol atariyo birebire biterwa no gukuramo no gutandukana nibihingwa. Uburyo bwa synthesis ya resveratrol ikoresha cyane cyane reaction ya Wittig kugirango tumenye gutera impeta ebyiri za benzene, kandi umusaruro urashobora kugera kuri 50%.
Ni izihe ngaruka za resveratrol?
- Kurwanya gusaza
Mu myaka yashize, byagaragaye ko polifenole nyinshi zifite anti-okiside ningaruka zikomeye zo kurwanya radical.
Nka antioxydants isanzwe, resveratrol igira imbaraga zo kwikuramo no kurwanya anti-lipide peroxidation, ndetse ugereranije na antioxydants gakondo nka vitamine C, butylhydroxytoluene, tocopherol, resveratrol igira ingaruka nziza ya antioxydeant.
Resveratrolikoresha imbaraga za antioxydeant cyane cyane binyuze mu gusiba cyangwa kubuza radicals yubuntu, kubuza lipide peroxidation, kugenzura imikorere yimisemburo ijyanye na antioxyde nubundi buryo.
Resveratrol irwanya gusaza biterwa na lipide peroxidisation iterwa na radicals yubusa na metabolite. Muri icyo gihe, resveratrol ikuraho radicals yubusa, igabanya ibirimo H₂O₂ mu ruhu, itezimbere imikorere ya ATPase, bityo ikagira ingaruka zo gutinda gusaza kwuruhu.
- Igenzura isukari mu maraso
Indwara ya Diyabete ni indwara idakira ikunze kugaragara, ariko kandi ikanayirinda byoroshye, ariko kubera iyo mpamvu akenshi ireka abantu bakayifata nabi, ikibazo cya diyabete, ni arteriosclerose, usibye kongera cyane amahirwe yo kwandura myocardial, stroke, niba aribyo bigira ingaruka kuri microvessels yimpyiko, bizakomeza gutera impyiko, kuburyo rero kugenzura isukari yamaraso nibyingenzi mubuzima.
Mu bushakashatsi buto, resveratrol (mg 150 buri munsi muminsi 30, igice cya DSM proprietary resVida) yazamuye isukari mu maraso (ku 4.2%) hamwe na insuline (ku 13.7%) kubantu bafite ibiro byinshi.
- Kurwanya ibibyimba, kurwanya kanseri
Resveratrol igira ingaruka zikomeye zo kubuza kanseri y'umwijima, kanseri y'ibere, kanseri y'amara, kanseri yo mu gifu, leukemia n'utundi tugingo ngengabuzima. Bamwe mu bahanga bemeje ko resveratrol igira ingaruka zigaragara kuri selile ya melanoma hakoreshejwe uburyo bwa MTT na cytometrie.
Byavuzwe ko resveratrol ishobora kongera imiti ivura kanseri, ikagira ingaruka "1 + 1> 2", kandi ikabuza neza uruhare rw'uturemangingo twa kanseri. Ariko kugeza ubu, kubera uburyo bukomeye bwo kurwanya ibibyimba bya resveratrol, abashakashatsi ntibigeze bumvikana ku buryo bukoreshwa.
- Indi mirimo
Resveratrol ifite kandi antibacterial, antioxidant, immunomodulatory, antiasthmatique nibindi bikorwa byibinyabuzima. Resveratrol irashakishwa cyane kubera ibikorwa bitandukanye byibinyabuzima.
Nigute ushobora gukuramo resveratrol?
- Uburyo bwo kuvoma ibimera bisanzwe
Resveratrol yakuweho kandi isukurwa mu nzabibu, ipfundo ryibishyimbo. Tekinoroji yo gukuramo ibicuruzwa ahanini ikubiyemo uburyo bwo kuvoma ibinyabuzima, uburyo bwo kuvoma alkali nuburyo bwo gukuramo enzyme, uburyo bwo kuvoma microwave, uburyo bwo gukuramo CO2 supercritical, gukuramo ultrasonic bifashwa nubundi buryo bushya nabwo bukoreshwa. Intego nyamukuru yo kwezwa ni ugutandukanya resveratrol cis, trans isomer na resveratrol Xib na resveratrol mbisi yakuwe kugirango ibone trans-resveratrol. Uburyo bukoreshwa muburyo bwo kweza ni chromatografiya, silika gel inkingi ya chromatografiya, chromatografi yoroheje, imikorere ya chromatografiya ikora cyane nibindi.
- Uburyo bwa Synthesis
Bitewe nubushobozi buke bwa resveratrol mubihingwa nigiciro kinini cyo kuvoma, gukoresha uburyo bwa chimique, biologique na genetique injeniyeri kugirango ubone resveratrol byabaye inzira yingenzi mubikorwa byiterambere. Imyitwarire ya Perkin, Hech reaction na Witting-Hormer reaction nuburyo bukuze bwimiti ikomatanya ya resveratrol, hamwe numusaruro wa 55.2%, 70% na 35.7%. Gukoresha tekinoroji yubuhanga mu kugenzura cyangwa kunoza inzira ya biosynthesis ya resveratrol kugirango ubone imirongo yibihingwa bitanga umusaruro mwinshi; Umusaruro wa resveratrol wiyongereyeho 1.5 ~ 3.0 na mutagenezi nubundi buryo.
Aogubio ni isosiyete izobereye mu gukora no gukwirakwiza ibintu bikora imiti, ibikoresho fatizo n’ibikomoka ku bimera, harimo n’intungamubiri zo gukora inyongeramusaruro z’abantu. Twibanze ku miti nibicuruzwa byinganda zimiti, ibiryo, intungamubiri n’amavuta yo kwisiga, kandi twiyemeje guha abakiriya inyongeramusaruro nziza kandi nziza.Resveratrol nikimwe mubintu dutanga mubikomoka ku bimera.
INGINGO Z'UMUNTU:
Ikigo cyacu gifite laboratoire ikoresha gazi ya chromatografiya igezweho kugirango igerageze cyane ubuziranenge nimbaraga zibikoresho byacu bibisi; kwemeza ko abakiriya bacu bakira ibicuruzwa byiza byigihe cyose.
UMURIMO W'UMUKUNZI:
Gukomeza intego yacu yo kuzuza Politiki yingwate yo guhaza, itsinda ryacu ryitangiye guhora ryiteguye guha buri mukiriya wacu serivisi ziyobora abakiriya bayobora inganda mubice byose byateganijwe.
Niba ushaka kumenya cyangwa kugura ubuziranenge bwa resveratrol, nyamuneka hamagara na kayla.
Twandikire: Keira Zhang
Imeri: kugurisha06@aogubio.com
Tel: +86 18066856327
Igihe cyo kohereza: Mutarama-08-2024
