Nadiifinta Sare ee Nicotinamide Adenine Dinucleotide Nad Cas 53-84-9
Waa maxay NAD+?
NAD waa u gaaban nicotinamide adenine dinucleotide.
Waa coenzyme waxayna ku jirtaa qaabka NAD+ iyo qaabka NADH.
Halkan waxaan kaga hadlaynaa NAD +.
Hadda, waxa jira warshad koronto oo yar unug kasta oo jidhkaaga ah. Waxaa loo yaqaan mitochondria.
Mitochondria waa isha dhammaan tamarta jirka. Laga soo bilaabo miisaanka qaadista, libiqsiga, dheefshiidka cuntada ilaa garaaca wadnaha, wax walba waxay ku tiirsan yihiin mitochondria.
NAD+ waa isha koowaad ee lagu hayo dhaqdhaqaaqa mitochondria.
Markii aan yaraa, jirkeena waxaa ka buuxay NAD+. Waxaan helnaa dhammaan NAD + aan rabno.
Laakiin marka aan da 'weyneyno, heerarkeena NAD + waxay bilaabaan inay u dhacaan sida dhagxaan. 20-kii sano ee kasta, heerka NAD+ wuxuu hoos u dhacayaa 50%.
FALANQEYNTA AASAASIGA AH
| Walxaha Tijaabada | Tilmaamaha | Natiijooyinka |
| Muuqashada | Caddaan ilaa budo ah ama budo crystalline ah | waafaqsan |
| Aqoonsiga | La jaanqaadka NMR | waafaqsan |
| Waxyaabaha ku jira (ICP-OES) | ≤0.5% | 0.01% |
| Biyo | ≤10.0% | 4.7% |
| PH | 2.0-4.0 | 3.3 |
| Daahirnimada (HPLC) | ≥98.5% | 99.71% |
| Qiimayn | ≥97.0% | 99.28% |
| Bir culus | ||
| Leedhka (Pb) | ≤0.5pm | waafaqsan |
| Arsenic (As) | ≤0.5pm | waafaqsan |
| Cadmium(Cd) | ≤0.5pm | waafaqsan |
| Meerkuri (Hg) | ≤0.5pm | waafaqsan |
| Baaritaanka Spectroscopy | ||
| A340/A260 | 0.39-0.47 (0.43±0.04) | 0.42 |
| A250/A260 | 0.75-0.91 (0.83±0.08) | 0.83 |
| A280/A260 | 0. 19-0.23 (0.21±0.02) | 0.22 |
| ε260 (pH=7.5) | 16.2- 19.8 (103L·mol- 1·cm- 1) ( 18 .0± 1.8) ×103 | 17.9×103 |
| ε340 (pH=10) | 5.7-6.9 (103L·mol- 1·cm- 1(6.3 ± 0.6) ×103 | 6.5×103 |
| Haraaga Solvent | ||
| Methanol | ≤ 1.0% | ND |
| Ethanol | ≤2.0% | 0.02% |
| Microbial | ||
| Lambarka Gumeysiga | ≤750CFU/g | |
| Escherichia Coli | ND | |
Shaqada
Nicotinamide Adenine Dinucleotide (NAD) waa koenzyme muhiim ah oo door muhiim ah ka ciyaara dheef-shiid kiimikaadka tamarta gacanta iyo falcelinta redox. Waa kuwan qaar ka mid ah hordhaca xirfadleyda ee NAD:
- Dheef-shiid kiimikaad tamarta gacanta:NAD waa arrin muhiim u ah u beddelashada nafaqooyinka cuntada u beddela tamarta gacanta. Waxay ka qaybqaadataa hababka sida glycolysis, neefsashada anaerobic, iyo neefsashada aerobic ee unugyada, caawinta soo saarida tamarta adenosine triphosphate (ATP) ee loo baahan yahay.
- Saamaynta Antioxidant:NAD sidoo kale waxay door muhiim ah ka ciyaartaa antioxidant-ka unugyada. Waxay la shaqayn kartaa enzymes-ka antioxidant si ay uga takhalusto xagjiriinta xorta ah iyo oksaydhiyeyaasha kale ee waxyeellada leh, yaraynta dhaawaca oksaydhka ee unugyada, waxay caawisaa ilaalinta caafimaadka unugyada iyo dib u dhigista habka gabowga.
- Dayactirka DNA:NAD waxay sidoo kale ku lug leedahay habka dayactirka DNA-da, caawinta si loo saxo burburka molecules DNA iyo ilaalinta daacadnimada macluumaadka hiddaha unugga.
- Kor u qaad shaqada difaaca:NAD waxay kor u qaadaa dhaqdhaqaaqa iyo shaqada unugyada difaaca waxayna taageertaa jawaabta habka difaaca ee fayrasyada, bakteeriyada iyo cudur-sidaha kale.
- Hagaajinta caafimaadka wadnaha iyo xididdada dhiigga:NAD ayaa la caddeeyey inay hagaajiso caafimaadka wadnaha iyo xididdada dhiigga. Waxay gacan ka geysataa kor u qaadida barti iyo shaqada derbiyada xididdada dhiigga waxayna wanaajisaa wareegga dhiigga, taas oo yaraynaysa khatarta cudurrada wadnaha iyo xididdada dhiigga.
Intaa waxaa dheer, NAD waxaa la ogaaday in ay la xiriirto habab badan oo nafsiyeed oo kale iyo cuduro, sida saameynta anti-kansarka, cudurrada neurodegenerative, sonkorowga, niyad-jabka, iwm. .
