Isuku ryinshi Nicotinamide Adenine Dinucleotide Nad Cas 53-84-9
Niki NAD +？
NAD ni ngufi kuri nicotinamide adenine dinucleotide.
Ni coenzyme kandi ibaho muburyo bwa NAD + na NADH.
Hano turavuga kuri NAD +.
Noneho, hari urugomero ruto muri buri selile yumubiri wawe. Yitwa mitochondria.
Mitochondriya niyo soko yingufu zose mumubiri. Kuva guterura ibiro, guhumbya, gusya ibiryo kugeza kumutima, ibintu byose bishingiye kuri mitochondria.
NAD + nisoko yambere yo gukomeza ibikorwa bya mitochondria.
Tukiri bato, imibiri yacu yari yuzuye NAD +. Twabonye NAD + yose dushaka.
Ariko uko dusaza, urwego rwa NAD + rutangira kugwa nkamabuye. Buri myaka 20, urwego rwa NAD + rugabanukaho 50%.
GUSESENGURA BY'INGENZI
| Kugerageza Ibintu | Ibisobanuro | Ibisubizo |
| Kugaragara | Ifu yera cyangwa umuhondo cyangwa ifu ya kristaline | Guhuza |
| Kumenyekanisha | Guhuza na NMR | Guhuza |
| Na Ibirimo (ICP-OES) | ≤0.5% | 0.01% |
| Amazi | ≤10.0% | 4.7% |
| PH | 2.0-4.0 | 3.3 |
| Isuku (HPLC) | ≥98.5% | 99,71% |
| Suzuma | ≥97.0% | 99.28% |
| Icyuma kiremereye | ||
| Kurongora (Pb) | ≤0.5ppm | Guhuza |
| Arsenic (As) | ≤0.5ppm | Guhuza |
| Cadmium (Cd) | ≤0.5ppm | Guhuza |
| Mercure (Hg) | ≤0.5ppm | Guhuza |
| Kugaragaza Spectroscopy | ||
| A340 / A260 | 0.39-0.47 (0.43 ± 0.04) | 0.42 |
| A250 / A260 | 0,75-0.91 (0.83 ± 0.08) | 0.83 |
| A280 / A260 | 0. 19-0.23 (0.21 ± 0.02) | 0.22 |
| ε260 (pH = 7.5) | 16.2- 19.8 (103L · mol- 1· Cm- 1) (18 .0 ± 1.8) × 103 | 17.9 × 103 |
| ε340 (pH = 10) | 5.7-6.9 (103L · mol- 1· Cm- 1) (6.3 ± 0,6) × 103 | 6.5 × 103 |
| Igisubizo gisigaye | ||
| Methanol | ≤ 1.0% | ND |
| Ethanol | ≤2.0% | 0,02% |
| Microbial | ||
| Umubare w'abakoloni | 50750CFU / g | |
| Escherichia Coli | ND | |
Imikorere
Nikotinamide Adenine Dinucleotide (NAD) ni coenzyme y'ingenzi igira uruhare runini mu ngirabuzimafatizo ya metabolism na redox reaction. Dore bimwe mubimenyesha umwuga kuri NAD:
- Ingufu za selile metabolism:NAD nikintu cyingenzi muguhindura intungamubiri mubiribwa imbaraga zingirabuzimafatizo. Ifite uruhare nka glycolysis, guhumeka kwa anaerobic, no guhumeka mu kirere mu ngirabuzimafatizo, bifasha kubyara ingufu za adenosine triphosphate (ATP) zitanga ingufu.
- Ingaruka ya Antioxydeant:NAD igira kandi uruhare runini rwa antioxydeant muri selile. Irashobora gukorana na enzymes ya antioxydeant kugirango ikure radicals yubusa hamwe nizindi oxyde yangiza, igabanye kwangiza okiside yangiza selile, ifashe kubungabunga ubuzima bwimikorere no gutinda gusaza.
- Gusana ADN:NAD igira kandi uruhare mugikorwa cyo gusana ADN, ifasha gukosora ibyangiritse muri molekile ya ADN no gukomeza ubusugire bwamakuru y’ingirabuzimafatizo.
- Kongera imikorere yubudahangarwa:NAD iteza imbere ibikorwa n'imikorere y'uturemangingo tw'umubiri kandi ishyigikira uburyo umubiri urinda virusi, bagiteri n'izindi virusi.
- Kunoza ubuzima bwumutima nimiyoboro yubwonko:NAD byagaragaye ko izamura ubuzima bwumutima nimiyoboro yubwonko. Ifasha kongera ubworoherane n'imikorere y'urukuta rw'imitsi y'amaraso kandi igahindura umuvuduko w'amaraso, bityo bikagabanya ibyago byo kurwara umutima n'umutima.
Byongeye kandi, byagaragaye ko NAD ifitanye isano nizindi nzira nyinshi zifata nindwara, nkingaruka zo kurwanya kanseri, indwara zifata ubwonko, diyabete, kwiheba, nibindi, ariko, gukoresha NAD nk'inyongera cyangwa ubuvuzi bwa farumasi bisaba ubushakashatsi bwinshi no kwemeza ivuriro .
