Nnukwu ịdị ọcha Nicotinamide Adenine Dinucleotide Nad Cas 53-84-9
Kedu ihe bụ NAD+?
NAD dị mkpụmkpụ maka nicotinamide adenine dinucleotide.
Ọ bụ coenzyme ma dị n'ụdị NAD + yana ụdị NADH.
N'ebe a, anyị na-ekwu maka NAD +.
Ugbu a, enwere obere ụlọ ọrụ ike na cell ọ bụla nke ahụ gị. A na-akpọ ya mitochondria.
Mitochondria bụ isi iyi ike niile dị na ahụ. Site na ibuli ihe dị arọ, na-egbuke egbuke, na-agbari nri ruo n'obi, ihe niile na-adabere na mitochondria.
NAD + bụ isi mmalite iji dobe ọrụ mitochondria.
Mgbe anyị dị obere, ahụ anyị jupụtara na NAD. Anyị na-enweta NAD + niile anyị chọrọ.
Mana ka anyị na-aka nká, ọkwa NAD + anyị na-amalite ịda dị ka nkume. Kwa afọ 20 ọ bụla, ọkwa NAD + gị na-agbada site na 50%.
Ntụle bụ isi
| Ihe na-anwale | Nkọwapụta | Nsonaazụ |
| Ọdịdị | Ọcha na-acha odo odo ma ọ bụ ntụ ntụ kristal | Dabara |
| njirimara | Dabaa na NMR | Dabara |
| Ọdịnaya (ICP-OES) | ≤0.5% | 0.01% |
| Mmiri | ≤10.0% | 4.7% |
| PH | 2.0-4.0 | 3.3 |
| Ịdị ọcha (HPLC) | ≥98.5% | 99.71% |
| Nyocha | ≥97.0% | 99.28% |
| Igwe dị arọ | ||
| Ndu (Pb) | ≤0.5pm | Dabara |
| Arsenic (As) | ≤0.5pm | Dabara |
| Cadmium (Cd) | ≤0.5pm | Dabara |
| Mercury (Hg) | ≤0.5pm | Dabara |
| Nchọpụta Spectroscopy | ||
| A340/A260 | 0.39-0.47 (0.43±0.04) | 0.42 |
| A250/A260 | 0.75-0.91 (0.83± 0.08) | 0.83 |
| A280/A260 | 0. 19-0.23 (0.21± 0.02) | 0.22 |
| ε260 (pH=7.5) | 16.2-19.8 (103L·mol- 1· cm- 1) ( 18 .0± 1.8) ×103 | 17.9 × 103 |
| ε340 (pH = 10) | 5.7-6.9 (103L·mol- 1· cm- 1) (6.3±0.6) ×103 | 6.5 × 103 |
| Ihe mgbaze fọdụrụnụ | ||
| Methanol | ≤ 1.0% | ND |
| Ethanol | ≤2.0% | 0.02% |
| Microbial | ||
| Ọnụọgụ Colonies | ≤750CFU/g | |
| Escherichia Coli | ND | |
Ọrụ
Nicotinamide Adenine Dinucleotide (NAD) bụ coenzyme dị mkpa nke na-arụ ọrụ dị mkpa na metabolism ike cellular na mmeghachi omume redox. Nke a bụ ụfọdụ mmalite ndị ọkachamara na NAD:
- Metabolism ike nke cell:NAD bụ isi ihe n'ịgbanwe nri na nri ka ọ bụrụ ike ekwentị. Ọ na-ekere òkè na usoro dị ka glycolysis, iku ume anaerobic, na iku ume ikuku n'ime sel, na-enyere aka ịmepụta adenosine triphosphate (ATP) ume ike.
- Mmetụta Antioxidant:NAD na-arụkwa ọrụ antioxidant dị mkpa na sel. Ọ nwere ike ịrụ ọrụ na enzymes antioxidant iji kpochapụ radicals n'efu na oxidants ndị ọzọ na-emerụ ahụ, belata mmebi oxidative nke mkpụrụ ndụ, nyere aka ịnọgide na-enwe ahụ ike cell na igbu oge usoro ịka nká.
- Ndozi DNA:NAD na-etinyekwa aka na nhazi DNA, na-enyere aka dozie mmebi nke mkpụrụ ndụ DNA ma nọgide na-eguzosi ike n'ezi ihe nke ozi mkpụrụ ndụ ihe nketa nke cell.
- Kwalite ọrụ mgbochi:NAD na-akwalite ọrụ na ọrụ nke mkpụrụ ndụ na-alụso ọrịa ọgụ ma na-akwado nzaghachi usoro ahụ ji alụso ọrịa ọgụ na nje, nje bacteria na nje ndị ọzọ.
- Melite ahụike obi na akwara ozi:Achọpụtara NAD ka ọ kwalite ahụike obi na ụbụrụ ụbụrụ. Ọ na-enyere aka ịkwalite ngbanwe na ọrụ nke mgbidi arịa ọbara ma na-eme ka mgbasa ọbara dịkwuo mma, si otú a na-ebelata ihe ize ndụ nke ọrịa obi na ụbụrụ ụbụrụ.
Tụkwasị na nke ahụ, a chọpụtala na NAD nwere njikọ na ọtụtụ usoro physiological na ọrịa ndị ọzọ, dị ka mmetụta mgbochi ọrịa cancer, ọrịa neurodegenerative, ọrịa shuga, ịda mbà n'obi, wdg. Otú ọ dị, iji NAD dịka mgbakwunye ma ọ bụ ọgwụgwọ ọgwụ na-achọkwu nyocha na nkwado ụlọ ọgwụ. .
