I-High Purity Nicotinamide Adenine Dinucleotide Nad Cas 53-84-9
Yini i-NAD+?
I-NAD imfushane nge-nicotinamide adenine dinucleotide.
Kuyi-coenzyme futhi ikhona ngefomu le-NAD+ nefomu le-NADH.
Lapha sikhuluma nge-NAD+.
Manje, kunesitsha samandla esincane kuwo wonke amangqamuzana omzimba wakho. Ibizwa ngokuthi i-mitochondria.
I-Mitochondria ingumthombo wawo wonke amandla emzimbeni. Kusukela ekuphakamiseni izinsimbi, ukucwayiza, ukugaya ukudla kuya ekushayeni kwenhliziyo, yonke into incike ku-mitochondria.
I-NAD+ ingumthombo oyinhloko wokugcina umsebenzi we-mitochondria.
Lapho sisebancane, imizimba yethu yayigcwele i-NAD+. Sithola yonke i-NAD+ esiyifunayo.
Kepha njengoba sikhula, amazinga ethu e-NAD+ aqala ukuwa njengamatshe. Njalo eminyakeni engama-20, izinga lakho le-NAD+ lehla ngo-50%.
UKUHLAZIYWA OKUSISEKELO
| Izinto Zokuhlola | Imininingwane | Imiphumela |
| Ukubukeka | Impushana emhlophe ukuya kokuphuzi noma i-crystalline powder | Kuyavumelana |
| Ukuhlonza | Vumelanisa ne-NMR | Kuyavumelana |
| I-Na Content (ICP-OES) | ≤0.5% | 0.01% |
| Amanzi | ≤10.0% | 4.7% |
| PH | 2.0-4.0 | 3.3 |
| Ubumsulwa (HPLC) | ≥98.5% | 99.71% |
| Isivivinyo | ≥97.0% | 99.28% |
| Insimbi enzima | ||
| Ukuhola(Pb) | ≤0.5ppm | Kuyavumelana |
| I-Arsenic(As) | ≤0.5ppm | Kuyavumelana |
| I-Cadmium(Cd) | ≤0.5ppm | Kuyavumelana |
| I-Mercury(Hg) | ≤0.5ppm | Kuyavumelana |
| Ukutholwa kwe-Spectroscopy | ||
| I-A340/A260 | 0.39-0.47 (0.43±0.04) | 0.42 |
| I-A250/A260 | 0.75-0.91 (0.83±0.08) | 0.83 |
| I-A280/A260 | 0. 19-0.23 (0.21±0.02) | 0.22 |
| ε260 (pH=7.5) | 16.2- 19.8(103L·mol- 1·cm- 1)( 18 .0± 1.8) ×103 | 17.9×103 |
| ε340 (pH=10) | 5.7-6.9(103L·mol- 1·cm- 1)(6.3±0.6) ×103 | 6.5×103 |
| I-Residual Solvent | ||
| I-Methanol | ≤ 1.0% | ND |
| I-Ethanol | ≤2.0% | 0.02% |
| I-Microbial | ||
| Inombolo yamaKoloni | ≤750CFU/g | |
| Escherichia Coli | ND | |
Umsebenzi
I-Nicotinamide Adenine Dinucleotide (NAD) iyi-coenzyme ebalulekile edlala indima ebalulekile kumetabolism yamandla eselula kanye nokusabela kwe-redox. Nazi izethulo zochwepheshe ze-NAD:
- I-Cellular energy metabolism:I-NAD iyisici esibalulekile ekuguquleni izakhamzimba ekudleni zibe amandla eselula. Ibamba iqhaza ezinqubweni ezifana ne-glycolysis, ukuphefumula kwe-anaerobic, nokuphefumula kwe-aerobic ngaphakathi kwamaseli, okusiza ukukhiqiza amandla adingekayo e-adenosine triphosphate (ATP).
- Umphumela we-Antioxidant:I-NAD nayo idlala indima ebalulekile ye-antioxidant kumaseli. Ingasebenza nama-enzyme e-antioxidant ukuze ikhiphe ama-radicals mahhala namanye ama-oxidants ayingozi, inciphise ukulimala kwe-oxidative kumaseli, isize ukugcina impilo yamangqamuzana futhi ibambezele inqubo yokuguga.
- Ukulungiswa kwe-DNA:I-NAD iphinde ibambe iqhaza enqubweni yokulungisa i-DNA, isiza ukulungisa umonakalo kuma-molecule e-DNA nokugcina ubuqotho bolwazi lofuzo lweseli.
- Thuthukisa ukusebenza komzimba:I-NAD ikhuthaza ukusebenza nokusebenza kwamaseli omzimba futhi isekela impendulo yamasosha omzimba kumagciwane, amagciwane kanye namanye amagciwane.
- Thuthukisa impilo yenhliziyo nemithambo ye-cerebrovascular:I-NAD ifakazelwe ukuthi ithuthukisa impilo yenhliziyo nemithambo ye-cerebrovascular. Kuyasiza ukuthuthukisa ukunwebeka nokusebenza kwezindonga zemithambo yegazi futhi kuthuthukise ukujikeleza kwegazi, ngaleyo ndlela kunciphise ingozi yezifo zenhliziyo nemithambo yegazi.
Ngaphezu kwalokho, i-NAD itholakale ihlobene nezinye izinqubo eziningi zomzimba nezifo, njengemiphumela yokulwa nomdlavuza, izifo ze-neurodeergenerative, isifo sikashukela, ukucindezeleka, njll. Nokho, ukusebenzisa i-NAD njengesengezo noma ukwelashwa kwemithi kudinga ucwaningo olwengeziwe nokuqinisekiswa komtholampilo. .
