Maʻemaʻe kiʻekiʻe Nicotinamide Adenine Dinucleotide Nad Cas 53-84-9
He aha ka NAD+?
He pōkole ʻo NAD no ka nicotinamide adenine dinucleotide.
He coenzyme a aia ma ke ʻano NAD+ a me ke ʻano NADH.
Eia mākou e kamaʻilio e pili ana iā NAD +.
I kēia manawa, aia kahi hale mana liʻiliʻi i loko o kēlā me kēia cell o kou kino. Kapa ʻia ʻo ia ka mitochondria.
ʻO Mitochondria ke kumu o ka ikehu a pau i loko o ke kino. Mai ka hāpai ʻana i nā mea kaumaha, ka uila, ka ʻeli ʻana i ka meaʻai a hiki i ka puʻuwai, hilinaʻi nā mea a pau i ka mitochondria.
ʻO NAD + ke kumu mua e mālama i ka hana mitochondria.
I ko mākou wā ʻōpiopio, ua piha ko mākou kino i NAD +. Loaʻa iā mākou nā NAD + a pau a mākou e makemake ai.
Akā i ko mākou mau makahiki, hoʻomaka kā mākou pae NAD + e hāʻule e like me nā pōhaku. I kēlā me kēia 20 makahiki, hāʻule kāu pae NAD + e 50%.
KA HOOLAHA KUMU
| Nā mea ho'āʻo | Nā kikoʻī | Nā hualoaʻa |
| Ka nana aku | ʻO ka pauka keʻokeʻo i ka melemele a i ʻole ka pauka crystalline | Kūlike |
| ʻIkepili | Kūlike me ka NMR | Kūlike |
| Na Maʻiʻo (ICP-OES) | ≤0.5% | 0.01% |
| Wai | ≤10.0% | 4.7% |
| PH | 2.0-4.0 | 3.3 |
| Maʻemaʻe (HPLC) | ≥98.5% | 99.71% |
| Hoʻāʻo | ≥97.0% | 99.28% |
| Metala kaumaha | ||
| Ke kēpau(Pb) | ≤0.5ppm | Kūlike |
| Arsenic(As) | ≤0.5ppm | Kūlike |
| Cadmium(Cd) | ≤0.5ppm | Kūlike |
| Mercury(Hg) | ≤0.5ppm | Kūlike |
| ʻIkeʻikeʻikeʻike | ||
| A340/A260 | 0.39-0.47 (0.43±0.04) | 0.42 |
| A250/A260 | 0.75-0.91 (0.83±0.08) | 0.83 |
| A280/A260 | 0. 19-0.23 (0.21±0.02) | 0.22 |
| ε260 (pH=7.5) | 16.2- 19.8(103L·mol- 1·cm- 1)( 18 .0± 1.8) ×103 | 17.9×103 |
| ε340 (pH=10) | 5.7-6.9(103L·mol- 1·cm- 1)(6.3±0.6) ×103 | 6.5×103 |
| Koena Solvent | ||
| Methanol | ≤ 1.0% | ND |
| Ethanol | ≤2.0% | 0.02% |
| Microbial | ||
| Helu Koni | ≤750CFU/g | |
| Escherichia Coli | ND | |
Hana
ʻO Nicotinamide Adenine Dinucleotide (NAD) he coenzyme koʻikoʻi e pāʻani ana i kahi kuleana nui i ka metabolism ikehu cellular a me nā hopena redox. Eia kekahi mau hoʻolauna ʻoihana i NAD:
- ʻO ka hoʻokele ikehu kelepona:ʻO NAD kahi kumu nui i ka hoʻololi ʻana i nā meaʻai i ka meaʻai i ka ikehu cellular. Hoʻokomo ʻo ia i nā kaʻina hana e like me ka glycolysis, ka hanu anaerobic, a me ka hanu aerobic i loko o nā cell, e kōkua ana i ka hoʻoulu ʻana i ka lako adenosine triphosphate (ATP) pono.
- Ka hopena antioxidant:He kuleana koʻikoʻi ko NAD i nā cell. Hiki iā ia ke hana me nā enzymes antioxidant e hoʻopau i nā radical manuahi a me nā mea ʻona ʻino ʻē aʻe, e hōʻemi i ka pōʻino oxidative i nā cell, e kōkua i ka mālama ʻana i ke olakino cell a hoʻopaneʻe i ke kaʻina hana ʻelemakule.
- Hoʻoponopono DNA:Hoʻopili pū ʻia ʻo NAD i ke kaʻina hana o ka hoʻoponopono DNA, e kōkua ana i ka hoʻoponopono ʻana i ka pōʻino i loko o nā molekala DNA a mālama i ka pono o ka ʻike genetic o ka cell.
- Hoʻonui i ka hana immune:Hoʻolaha ʻo NAD i ka hana a me ka hana o nā cell immune a kākoʻo i ka pane ʻana o ka ʻōnaehana pale i nā maʻi, bacteria a me nā pathogens ʻē aʻe.
- Hoʻonui i ka olakino cardiovascular a me ka cerebrovascular:Ua hōʻike ʻia ʻo NAD e hoʻomaikaʻi i ke olakino cardiovascular a me cerebrovascular. Kōkua ia i ka hoʻonui ʻana i ka elasticity a me ka hana o nā paia kīʻaha koko a hoʻomaikaʻi i ke kahe o ke koko, a laila e hōʻemi ana i ka hopena o nā maʻi cardiovascular a me cerebrovascular.
Eia kekahi, ua ʻike ʻia ʻo NAD e pili ana i nā kaʻina hana physiological ʻē aʻe a me nā maʻi, e like me nā hopena anti-cancer, nā maʻi neurodegenerative, diabetes, puʻuwai, a me nā mea ʻē aʻe. .
