High Purity Nicotinamide Adenine Dinucleotide Nad Cas 53-84-9
NAD+ ke eng?
NAD e khutsufetse bakeng sa nicotinamide adenine dinucleotide.
Ke coenzyme mme e teng ka sebopeho sa NAD+ le sebopeho sa NADH.
Mona re bua ka NAD+.
Hona joale, ho na le semela se senyenyane sa matla seleng e 'ngoe le e' ngoe ea 'mele oa hau. E bitsoa mitochondria.
Mitochondria ke mohloli oa matla ohle 'meleng. Ho tloha ho phahamisa litšepe, ho panya, ho sila lijo ho ea ho ho otla ha pelo, ntho e 'ngoe le e' ngoe e itšetlehile ka mitochondria.
NAD+ ke mohloli oa mantlha oa ho boloka ts'ebetso ea mitochondria.
Ha re sa le bacha, ’mele ea rōna e ne e tletse NAD +. Re fumana NAD+ eohle eo re e batlang.
Empa ha re ntse re tsofala, maemo a rona a NAD + a qala ho oa joalo ka majoe. Lilemo tse ling le tse ling tse 20, boemo ba hau ba NAD+ bo theoha ka 50%.
TS'ELISO MOTHEO
| Lintho tsa ho Leka | Litlhaloso | Liphetho |
| Ponahalo | Phofo e tšoeu ho isa ho bosehla kapa phofo ea crystalline | E lumellana |
| Boitsebiso | E lumellana le NMR | E lumellana |
| Na Content (ICP-OES) | ≤0.5% | 0.01% |
| Metsi | ≤10.0% | 4.7% |
| PH | 2.0-4.0 | 3.3 |
| Purity (HPLC) | ≥98.5% | 99.71% |
| Tlhahlobo | ≥97.0% | 99.28% |
| Tšepe e boima | ||
| Ketapele(Pb) | ≤0.5ppm | E lumellana |
| Arsenic(As) | ≤0.5ppm | E lumellana |
| Cadmium(Cd) | ≤0.5ppm | E lumellana |
| Mercury(Hg) | ≤0.5ppm | E lumellana |
| Ho fumanoa ha Spectroscopy | ||
| A340/A260 | 0.39-0.47 (0.43±0.04) | 0.42 |
| A250/A260 | 0.75-0.91 (0.83±0.08) | 0.83 |
| A280/A260 | 0. 19-0.23 (0.21±0.02) | 0.22 |
| ε260 (pH=7.5) | 16.2- 19.8(103L·mol- 1·cm- 1)( 18 .0± 1.8) ×103 | 17.9×103 |
| ε340 (pH=10) | 5.7-6.9(103L·mol- 1·cm- 1)(6.3±0.6) ×103 | 6.5×103 |
| Residual Solvent | ||
| Methanol | ≤ 1.0% | ND |
| Ethanol | ≤2.0% | 0.02% |
| Kokoana | ||
| Nomoro ea Likolone | ≤750CFU/g | |
| Escherichia Coli | ND | |
Mosebetsi
Nicotinamide Adenine Dinucleotide (NAD) ke coenzyme ea bohlokoa e bapalang karolo ea bohlokoa ho metabolism ea matla a cellular le karabelo ea redox. Mona ke likenyelletso tsa profeshenale tsa NAD:
- Metabolism ea matla a cellular:NAD ke ntlha ea bohlokoa ho fetoleng limatlafatsi lijong hore e be matla a cellular. E kenya letsoho lits'ebetsong tse kang glycolysis, anaerobic respiration, le aerobic respiration ka har'a lisele, e thusa ho hlahisa matla a hlokahalang a adenosine triphosphate (ATP).
- Phello ea Antioxidant:NAD e boetse e bapala karolo ea bohlokoa ea antioxidant liseleng. E ka sebetsa ka li-enzyme tsa antioxidant ho qhekella li-radicals tsa mahala le li-oxidants tse ling tse kotsi, ho fokotsa tšenyo ea oxidative liseleng, ho thusa ho boloka bophelo bo botle ba lisele le ho liehisa ts'ebetso ea botsofali.
- Ho lokisa DNA:NAD e boetse e kenya letsoho tšebetsong ea tokiso ea DNA, e thusa ho lokisa tšenyo e teng limolek'huleng tsa DNA le ho boloka bots'epehi ba litaba tsa lefutso tsa sele.
- Ntlafatsa ts'ebetso ea 'mele ea ho itšireletsa mafung:NAD e khothaletsa ts'ebetso le ts'ebetso ea lisele tsa 'mele tsa ho itšireletsa mafung mme e ts'ehetsa karabelo ea sesole sa 'mele ho livaerase, libaktheria le likokoana-hloko tse ling.
- Ntlafatsa bophelo bo botle ba pelo le cerebrovascular:NAD e netefalitsoe ho ntlafatsa bophelo bo botle ba pelo le methapo ea pelo. E thusa ho ntlafatsa elasticity le ts'ebetso ea marako a methapo ea mali le ho ntlafatsa phallo ea mali, kahoo e fokotsa kotsi ea mafu a pelo le methapo ea mali.
Ho phaella moo, NAD e fumanoe e amana le mekhoa e meng e mengata ea 'mele le maloetse, a kang liphello tse khahlanong le kankere, mafu a neurodegenerative, lefu la tsoekere, khatello ea maikutlo, joalo-joalo Leha ho le joalo, ho sebelisa NAD e le tlatsetso kapa phekolo ea meriana ho hloka lipatlisiso tse eketsehileng le bopaki ba kliniki. .
