Ucoceko oluPhezulu lweNicotinamide Adenine Dinucleotide Nad Cas 53-84-9
Yintoni i-NAD+?
I-NAD imfutshane kwi-nicotinamide adenine dinucleotide.
Yi-coenzyme kwaye ikhona kwifomu ye-NAD + kunye nefom ye-NADH.
Apha sithetha ngeNAD +.
Ngoku, kukho isityalo esincinci samandla kwiseli nganye yomzimba wakho. Ibizwa ngokuba yi-mitochondria.
IMitochondria ngumthombo wawo onke amandla emzimbeni. Ukusuka ekuphakamiseni iintsimbi, ukuqhwanyaza, ukwetyisa ukutya ukuya ekubetheni kwentliziyo, yonke into ixhomekeke kwimitochondria.
I-NAD + ngowona mthombo uphambili wokugcina umsebenzi we-mitochondria.
Xa sasisebancinci, imizimba yethu yayizele yiNAD +. Sifumana yonke i-NAD + esiyifunayo.
Kodwa njengoko sikhula, amanqanaba ethu e-NAD + aqala ukuwa njengamatye. Rhoqo kwiminyaka engama-20, inqanaba lakho le-NAD + lehla nge-50%.
UPHICOTHO OLUYISISEKO
| Izinto zoVavanyo | Iinkcukacha | Iziphumo |
| Imbonakalo | Umgubo omhlophe ukuya kumthubi okanye umgubo wekristale | Iyahambelana |
| Ukuchongwa | Yabelana ne-NMR | Iyahambelana |
| Na Umxholo (ICP-OES) | ≤0.5% | 0.01% |
| Amanzi | ≤10.0% | 4.7% |
| PH | 2.0-4.0 | 3.3 |
| Ubunyulu (HPLC) | ≥98.5% | 99.71% |
| Isivavanyi | ≥97.0% | 99.28% |
| Intsimbi enzima | ||
| Khokela(Pb) | ≤0.5ppm | Iyahambelana |
| Arsenic(As) | ≤0.5ppm | Iyahambelana |
| I-Cadmium(Cd) | ≤0.5ppm | Iyahambelana |
| IMercury(Hg) | ≤0.5ppm | Iyahambelana |
| Ukufunyanwa kweSpectroscopy | ||
| A340/A260 | 0.39-0.47 (0.43±0.04) | 0.42 |
| A250/A260 | 0.75-0.91 (0.83±0.08) | 0.83 |
| A280/A260 | 0. 19-0.23 (0.21±0.02) | 0.22 |
| ε260 (pH=7.5) | 16.2- 19.8(103L·mol-1·i-cm-1)( 18 .0± 1.8) ×103 | 17.9×103 |
| ε340 (pH=10) | 5.7-6.9(103L·mol-1·i-cm-1)(6.3±0.6) ×103 | 6.5×103 |
| Intsalela yokunyibilika | ||
| IMethanol | ≤ 1.0% | ND |
| I-Ethanol | ≤2.0% | 0.02% |
| Intsholongwane | ||
| Inombolo yeeKoloni | ≤750CFU/g | |
| Escherichia Coli | ND | |
Umsebenzi
I-Nicotinamide Adenine Dinucleotide (NAD) yi-coenzyme ebalulekileyo edlala indima ebalulekileyo kwimetabolism yamandla eselula kunye nokuphendula kwe-redox. Nazi ezinye iintshayelelo zobungcali kwi-NAD:
- Imetabolism yamandla eSelula:I-NAD yinto ephambili ekuguquleni izondlo ekutyeni zibe amandla eselula. Ithatha inxaxheba kwiinkqubo ezifana ne-glycolysis, ukuphefumla kwe-anaerobic, kunye nokuphefumla kwe-aerobic ngaphakathi kweeseli, inceda ukuvelisa i-adenosine triphosphate (ATP) efunekayo yokunikezelwa kwamandla.
- Isiphumo se-Antioxidant:I-NAD ikwadlala indima ebalulekileyo ye-antioxidant kwiiseli. Inokusebenza kunye ne-antioxidant enzymes ukukhupha i-radicals yamahhala kunye nezinye i-oxidants ezinobungozi, ukunciphisa umonakalo owenziwe nge-oxidative kwiiseli, ukunceda ukugcina impilo yeseli kunye nokulibazisa inkqubo yokuguga.
- Ukulungiswa kweDNA:I-NAD nayo ibandakanyeka kwinkqubo yokulungiswa kwe-DNA, inceda ukulungisa umonakalo kwiimolekyuli ze-DNA kunye nokugcina ingqibelelo yolwazi lwemfuza yeseli.
- Ukuphucula ukusebenza komzimba:I-NAD ikhuthaza umsebenzi kunye nokusebenza kweeseli zomzimba kwaye ixhasa impendulo yamajoni omzimba kwiintsholongwane, iibhaktheriya kunye nezinye iintsholongwane.
- Ukuphucula impilo yentliziyo kunye ne-cerebrovascular:I-NAD ibonakaliswe ukuba iphucula impilo ye-cardiovascular and cerebrovascular. Inceda ukomeleza ukuqina kunye nokusebenza kweendonga zemithambo yegazi kwaye iphucule ukujikeleza kwegazi, ngaloo ndlela inciphisa umngcipheko wezifo zentliziyo kunye ne-cerebrovascular.
Ukongezelela, i-NAD ifunyenwe inxulumene nezinye iinkqubo ezininzi zomzimba kunye nezifo, ezifana nemiphumo yokuchasana nomhlaza, izifo ze-neurodeergenerative, isifo sikashukela, ukudandatheka, njl. .
