High Purity Nicotinamide Adenine Dinucleotide Nad Cas 53-84-9
NAD+ ndi chiyani?
NAD ndiyofupikitsa nicotinamide adenine dinucleotide.
Ndi coenzyme ndipo ilipo mu mawonekedwe a NAD + ndi mawonekedwe a NADH.
Apa tikukamba za NAD +.
Tsopano, pali kachingwe kakang'ono ka mphamvu mu selo lililonse la thupi lanu. Amatchedwa mitochondria.
Mitochondria ndi gwero la mphamvu zonse m'thupi. Kuyambira kukweza zolemera, kuthwanima, kugaya chakudya mpaka kugunda kwa mtima, chilichonse chimadalira mitochondria.
NAD+ ndiye gwero lalikulu losunga ntchito za mitochondria.
Pamene tinali achichepere, matupi athu anali odzaza ndi NAD +. Timapeza NAD + yonse yomwe tikufuna.
Koma tikamakalamba, milingo yathu ya NAD + imayamba kugwa ngati miyala. Zaka 20 zilizonse, mulingo wanu wa NAD + umatsika ndi 50%.
KUSANGALALA KWAMBIRI
| Zinthu Zoyesera | Zofotokozera | Zotsatira |
| Maonekedwe | Ufa woyera mpaka wachikasu kapena ufa wonyezimira | Zimagwirizana |
| Chizindikiritso | Gwirizanani ndi NMR | Zimagwirizana |
| Na Content (ICP-OES) | ≤0.5% | 0.01% |
| Madzi | ≤10.0% | 4.7% |
| PH | 2.0-4.0 | 3.3 |
| Purity (HPLC) | ≥98.5% | 99.71% |
| Kuyesa | ≥97.0% | 99.28% |
| Chitsulo cholemera | ||
| Kutsogolera (Pb) | ≤0.5ppm | Zimagwirizana |
| Arsenic (As) | ≤0.5ppm | Zimagwirizana |
| Cadmium (Cd) | ≤0.5ppm | Zimagwirizana |
| Mercury (Hg) | ≤0.5ppm | Zimagwirizana |
| Kuzindikira kwa Spectroscopy | ||
| A340/A260 | 0.39-0.47 (0.43±0.04) | 0.42 |
| A250/A260 | 0.75-0.91 (0.83±0.08) | 0.83 |
| A280/A260 | 0. 19-0.23 (0.21±0.02) | 0.22 |
| ε260 (pH=7.5) | 16.2- 19.8(103L · mol-1·cm-1)( 18 .0± 1.8) × 103 | 17.9 × 103 |
| ε340 (pH=10) | 5.7-6.9(103L · mol-1·cm-1)(6.3±0.6) ×103 | 6.5 × 103 |
| Zosungunulira Zotsalira | ||
| Methanol | ≤ 1.0% | ND |
| Ethanol | ≤2.0% | 0.02% |
| Tizilombo tating'onoting'ono | ||
| Nambala ya Makoloni | ≤750CFU/g | |
| Escherichia Coli | ND | |
Ntchito
Nicotinamide Adenine Dinucleotide (NAD) ndi coenzyme yofunikira yomwe imagwira ntchito yofunika kwambiri pakupanga mphamvu zama cell metabolism komanso machitidwe a redox. Nawa mawu oyambitsa akatswiri a NAD:
- Ma cell amphamvu metabolism:NAD ndiye chinthu chofunikira kwambiri pakusintha zakudya m'zakudya kukhala mphamvu zama cell. Imagwira nawo ntchito monga glycolysis, kupuma kwa anaerobic, ndi kupuma kwa aerobic mkati mwa maselo, zomwe zimathandiza kupanga mphamvu ya adenosine triphosphate (ATP) yofunikira.
- Mphamvu ya Antioxidant:NAD imagwiranso ntchito yofunika kwambiri ya antioxidant m'maselo. Itha kugwira ntchito ndi ma enzymes a antioxidant kuti awononge ma free radicals ndi zina zowononga okosijeni, kuchepetsa kuwonongeka kwa okosijeni m'maselo, kuthandizira kukhala ndi thanzi la cell ndikuchedwetsa ukalamba.
- Kukonza DNA:NAD imakhudzidwanso ndi kukonza kwa DNA, kuthandiza kukonza kuwonongeka kwa mamolekyu a DNA ndikusunga umphumphu wa chidziwitso cha chibadwa cha selo.
- Kupititsa patsogolo chitetezo cha mthupi:NAD imathandizira magwiridwe antchito ndi magwiridwe antchito a chitetezo chamthupi ndikuthandizira chitetezo chamthupi ku ma virus, mabakiteriya ndi tizilombo toyambitsa matenda.
- Kupititsa patsogolo thanzi la mtima ndi cerebrovascular:NAD yatsimikiziridwa kuti imathandizira thanzi la mtima ndi ubongo. Zimathandizira kukulitsa kukhazikika komanso kugwira ntchito kwa makoma a mitsempha yamagazi ndikuwongolera kufalikira kwa magazi, potero kuchepetsa chiopsezo cha matenda amtima ndi cerebrovascular.
Kuonjezera apo, NAD yapezeka kuti ikugwirizana ndi njira zina zambiri za thupi ndi matenda, monga zotsatira zotsutsana ndi khansa, matenda a neurodegenerative, shuga, kuvutika maganizo, etc. .
