Nutrition Supplement Food Grade Oleanolic Acid Powder
What is oleanolic acid?
Oleanolic acid (OA), a natural hydroxyl pentacyclic triterpenoid acid (HPTA) similar to betulinic acid, ursolic acid;
Where can you find oleanolic acid?
Some fruits like apples, pomegranate, lemon, bilberries, olives contain oleanolic acid.
| Herb Name | Oleanolic acid content | Test method |
| Ligustrum lucidum Ait | 0.8028% | HPLC |
| Verbena Officinalis L | 0.071%-0.086% | HPLC |
| Prunella vulgaris L | 3.47%-4.46% | HPLC |
| Hemsley Chinensis Cogn. | 1.5%～2% | HPLC |
Currently, Chinese herb Hemsley Chinensis Cogn still is the most commercial raw material for extracting oleanolic acid.
Hemsley Chinensis Cogn. Introduction
Hemsleya chinensis Cogn. is a perennial climbing herb, also is traditional Chinese medicine.
- Familia: Cucurbitaceae
- Tribus: Gomphogyneae
- Genus: Hemsleya
- Species: H. amabilis
The herb is distributed in provinces Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Born in the forest edge and valley shrubs at an altitude of about 2,000 meters.
Active ingredients: contains Hemslolide Mal、Ma3、H1; Chikusetsusaponin-Iva; dihydro cucurbitacin F-25-acetate; dilydrocucurbitacin F; oleanolic acid-beta-Hlucosyloleanolate; Hemsamabilinin A; Cu-curbitacinⅡb-2-beta-D-glucopyranoside.
Extraction of Oleanolic acid from Hemsleya Chinensis Cogn.
BASIC ANALYSIS
| Item of Analysis | Specification | Results | Test Methods |
| Assay | ≥98.0% | 98.4% | HPLC |
| Organoleptic | |||
| Appearance | Powder | Conform | Organoleptic |
| Color | Off-white crystalline powder | Conform | Organoleptic |
| Odor | Odorless and tasteless | Conform | Organoleptic |
| Physical Characteristics | |||
| Loss on drying | ≤0.5% | 0.01% | USP<731> |
| Residue | ≤0.1% | 0.039% | USP<561> |
| Specific rotation | 75.0°-83.0° | 78.2° | CP2010 |
| Heavy metals | |||
| Total Heavy Metals | 20ppm Max | Conform | USP<231>method II |
| Lead (Pb) | 3ppm NMT | Conform | ICP-MS |
| Arsenic (As) | 2ppm NMT | Conform | ICP-MS |
| Cadmium (Cd) | 1ppm NMT | Conform | ICP-MS |
| Mercury (Hg) | 0.1ppm NMT | Conform | ICP-MS |
| Microbiological Tests | |||
| Total Plate Count: | NMT 5,000 cfu/g | Conform | AOAC |
| Yeast & Mold: | NMT 300 cfu/g | Conform | AOAC |
| Salmonella: | Negative | Conform | AOAC |
| E.Coli.: | Negative | Conform | AOAC |
Function
Oleanolic Acid (ursolic acid) is a natural triterpenoid compound widely found in plants, such as bearberry, olives, blueberries, etc. Here are some professional introductions to Oleanolic Acid:
- Anti-inflammatory and antioxidant effects: Ursolic acid has significant anti-inflammatory and antioxidant activities. It can reduce inflammatory reactions, inhibit the release of inflammatory mediators, remove free radicals in the body, and reduce damage caused by oxidative stress.
- Liver protection: Ursolic acid has a protective effect on the liver. It promotes liver cell regeneration and repair, reducing the risk of liver damage. Ursolic acid can also prevent and treat liver diseases such as fatty liver by regulating fat metabolism in the liver.
- Anti-tumor activity: Ursolic acid has inhibitory effects on certain tumor cells. It can exert anti-tumor activity by regulating cell apoptosis, inhibiting the proliferation and invasion of tumor cells, and regulating the signaling pathways of cancer cells.
- Hypoglycemic effect: Ursolic acid has a certain effect on lowering blood sugar and improving pancreatic islet cell function. It promotes insulin secretion and improves insulin sensitivity, thereby helping to manage diabetes and prevent related complications.
- Antibacterial and antiviral activity: Ursolic acid has certain antibacterial and antiviral activity against a variety of bacteria and viruses. It inhibits the growth and replication of bacteria and viruses, reducing the risk of infection and disease.
In addition, ursolic acid has been found to have skin protective, antioxidant properties, and resistance to ischemic heart disease.
