Waa maxay Nattokinase?
Nattokinase (NK) waa Bacillus subtilis protein kinase, serine protease ay soo saarto Bacillus subtilis natto inta lagu jiro habka halsano ee natto. Waxay leedahay shaqooyinka kala dirida xinjirowga dhiigga, yaraynta viscosity dhiigga, hagaajinta wareegga dhiigga, jilicsanaanta iyo kordhinta barti vascular.
Sannadkii 1980-kii, waxaa laga helay Natto in ay ka kooban tahay 275 amino acids oo loo habeeyey hab go'an, oo miisaankoodu yahay 27724. Waxa uu leeyahay hawl gaar ah oo ah in uu gooyo xinjirowga dhiigga, saameynteeda firfircoonna waxaa matalaya unugga gudaha ee FU.
sifooyinka jirka iyo kiimikaad
Nattokinase si degdeg ah ayuu denatures iyo denatures at heerkul ka badan 80 ℃, laakiin baraf-dhalaalaya soo noqnoqda saamayn yar ku leh.
Nattokinase waxay xasilisaa 10 daqiiqo gudahood marka qiimaha pH uu ka kordho 7 ilaa 12; Marka qiimaha pH uu ka hooseeyo 5, si degdeg ah ayuu u diidaa oo noqdaa mid firfircoon.
Ka dib marka la isku daro nattokinase walxaha viscous, waxay sii wadi kartaa dhaqdhaqaaqa aan ka badnayn 7.5% jawi acidic leh qiimaha pH ee 2-3.
Nattokinase waa molecule weyn oo hal silsilad ah peptidase kaas oo loo kala qaybin karo jajabyo amino acid ama silsilado peptide miisaankoodu yar yahay casiirka dheefshiidka mindhicirka (chymotrypsin, trypsin, dareeraha xiidmaha yar, iwm.).
Qiimaha nafaqada ee natto
Natto waa cunto shaqaynaysa oo laga sameeyay digirta la kariyey ee bakteeriyadu khamiirisay. Marka lagu daro ilaalinta nafaqooyinka soybean cayriin, waxa kale oo ay leedahay heerar sare oo ka mid ah qaybaha qaarkood sida borotiinka, fiber, calcium, iron, potassium, iyo vitamins marka loo eego digirta la kariyey.
Waxa ku jira biotin B1, fitamiin B2, iyo macdano kale, gaar ahaan kaalshiyamka, birta, iyo potassium, xitaa way ka badan tahay tan ukunta. Haddii la barbardhigo natto ukunta iyo hilibka lo'da, waxa ku jira borotiinka 100g ee natto waxay u dhigantaa 3 ukun ama 80g oo hilib lo'aad ah. Maadada amino acid ee ku jirta natto sidoo kale waa mid aad hodan u ah, taas oo ay ugu wacan tahay soo saarista fiitamiinada iyo enzymes kala duwan inta lagu jiro habka halsano, sida amylase, protease, lipase, cellulase, nattokinase, lysozyme, glutamic acid transpeptidase, iwm. ficilka enzymes-ka, borotiinka iyo nafaqooyinka kale way jajaban yihiin, markaa heerka dheefshiidka ee natto (85%) wuxuu ka sarreeyaa soybean la kariyey (68%), taas oo nafaqo badan oo sahlan in la nuugo.
Cilmi-baarista doorka
NattoKinase (NK) waa borotiin leh miisaan kelli ah oo aad uga yar UK, SK, iyo tPA, lagana soo saaray cuntada natto ama ay khamiirisay bakteeriyada natto. Waxa nuugi kara xiidmaha. In vitro iyo in vivo sifooyinka thrombolytic ee NK ayaa lagu go'aamiyay tijaabooyin, waxaana la ogaaday in in vivo thrombolytic dhaqdhaqaaqa NK ay afar jeer ka badan tahay enzyme fibrinolytic. Si dhakhso ah ayey u shaqeysaa oo waxay ku sii jirtaa vivo waqti dheer, waxayna sidoo kale kicin kartaa tPA ee jirka, taasoo ka dhigaysa mid khafiif ah Si joogto ah u wanaajiso waxqabadka fibrinolytic ee dhiigga. Bukaannada halista ugu jira wadna xanuunka myocardial waxay u baahan yihiin in ay isku duraan 300000 unug oo urokinase ah markiiba, 50 garaam oo natto ah waxa ku jira 800000 unug urokinase ah oo loogu talagalay thrombolysis.
Hawlaha ugu muhiimsan
Saamaynta muhiimka ah ee nattokinase waxay si gaar ah waxtar ugu leedahay xinjirowga dhiigga hore. Nattokinase wuxuu ku gaaraa saameyn toos ah thrombolytic by hydrolyzing fibrin ugu weyn ee thrombus, oo hadda waa walaxda kaliya ee dabiiciga ah ee la helay si ay u milaan thrombus duug ah.
Sannadkii 2015, Jaamacadda Caafimaadka ee Tokyo waxay samaysay tijaabo trombolytic ah oo ay la socoto nattokinase ee bini'aadamka, taas oo xaqiijinaysa in nattokinase ay kor u qaadi karto awoodda fibrinolytic ee jirka oo si wax ku ool ah u milmaan xinjirowga dhiigga. Warbixinta cilmi-baarista waxaa cinwaan looga dhigay "Single dose afka nattokinase thrombolysis iyo xoojinta xinjirowga lidka ku ah" waxaana lagu daabacay Warbixinnada Sayniska 2015; 5: 11601.
2016, 48 saacadood oo tijaabo ah xinjirowga dhiigga, 300FU ee nattokinase ayaa lagu dabaqay thrombi hore ee saacadaha 56, taas oo muujinaysa in thrombus si buuxda u milmay 2 saacadood gudahood; Xawaaraha thrombolysis ee isticmaalka 150FU nattokinase aad ayuu uga sarreeyaa isticmaalka isla u dhigma urokinase [1]. Cilmi baaris ayaa muujisay in nattokinase aysan wax saameyn ah ku yeelan plasma fibrinogen, taasoo ka dhigaysa mid u nugul dhiig-baxa. Waxa kale oo ay si wax ku ool ah u hawlgelin kartaa habka xinjirowga dhiigga ee jidhka, taas oo ka dhigaysa jidhka ka hortagga xinjirowga iyada oo loo marayo isticmaalka muddada dheer, taas oo hubinaysa caafimaadka wadnaha iyo xididdada dhiigga.
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Waqtiga boostada: Seb-11-2023
