Deoxyarbutin, monga mpikisano wa Tyrosinase inhibitor, imatha kuyendetsa kupanga melanin, kugonjetsa mtundu wa pigmentation, kutayika mawanga akuda pakhungu, ndikukhala ndi khungu lofulumira komanso lokhalitsa. Mphamvu yoletsa ya deoxyaarbutin pa Tyrosinase mwachiwonekere imakhala yoposa zoyambitsa zina zoyera, ndipo kuyera ndi kuwunikira kumatha kutheka ndikugwiritsa ntchito pang'ono. Deoxyarbutin ilinso ndi mphamvu ya antioxidant
- Dzina lachi China Deoxyarbutin
- Dzina lachilendo Deoxyarbutin
- Dzina lakutchulidwa p - (tetrahydro-2H-pyran-2-oxy) phenol
- Njira ya mankhwala C11H14O3
- Kulemera kwa molekyulu 194.23
- Nambala yolowera CAS 53936-56-4
- Dzina lachingerezi 4- [(Tetrahydro-2H-pyran-2-yl) oxy] phenol
- Kuyera ≥ 98%
Deoxyarbutinmonga m'badwo watsopano wa zodzikongoletsera kuwala ndi whitening yogwira wothandizira, zimagwiritsa ntchito patsogolo whitening zodzoladzola.
Yesani
Kusintha kwa melanogenesis mu melanocyte kumatha kutheka pogwiritsa ntchito mankhwala omwe amagawana ma homologies opangidwa ndi gawo lapansi la tyrosine ndipo motero amalepheretsa ntchito yothandiza ya tyrosinase. Tapanga tyrosinase inhibitor yatsopano, deoxyArbutin (dA), kutengera izi. DeoxyArbutin amawonetsa kuletsa kogwira mtima kwa bowa tyrosinase mu vitro ndi Ki yomwe ili kutsika ka 10 kuposa hydroquinone (HQ) ndi 350 kutsika kuposa arbutin. Mu mtundu wopanda tsitsi, wa pigmented guinea pig model, dA adawonetsa kuwunikira kofulumira komanso kosasunthika komwe kudatha kusinthidwa mkati mwa milungu 8 itayimitsa kugwiritsa ntchito mitu.
Mosiyana ndi izi, HQ idapangitsa kuyanika kwapang'onopang'ono koma kosakhazikika pomwe kojic acid ndi arbutin siziwonetsa kuwala kwa khungu. Zotsatira zochokera kumagulu oyesa chitetezo zidathandizira kukhazikitsidwa konse kwa dA ngati molekyulu yotheka kuchitapo kanthu. M'mayesero achipatala a anthu, chithandizo chamankhwala chapamwamba cha dA kwa milungu 12 chinapangitsa kuchepa kwakukulu kapena pang'ono pakupepuka kwapakhungu komanso kusintha kwa ma lentigine adzuwa pagulu la anthu akhungu kapena khungu lakuda, motsatana. Deta iyi ikuwonetsa kuti dA ili ndi zoletsa za tyrosinase zomwe zingapangitse kuti khungu liwende ndipo zitha kugwiritsidwa ntchito kuwongolera zotupa za hyperpigmentary.
Mawu Oyamba
Melasma (chloasma) ndi vuto lodziwika bwino la mtundu wa pigmentary pakhungu lomwe limadziwika ndi kuwala kosakhazikika mpaka zigamba zakuda pankhope, zomwe nthawi zambiri zimabweretsa zovuta zamisala komanso zamalingaliro kwa anthu okhudzidwa. Komabe, zochitika zoyambitsa matenda a melasma sizikumveka bwino. Melasma imapezeka kwambiri mwa anthu omwe ali ndi khungu la Fitzpatrick IV mpaka VI kuposa omwe ali ndi khungu labwino (mitundu I mpaka III). Melasma imadziwikanso kuti ndiyofala kwambiri pakati pa akazi kuposa amuna komanso yofala kwambiri pakati pa anthu aku Asia, Latinos ndi African-America kuposa pakati pa anthu aku Caucasus. Pafupifupi 50% mpaka 70% ya amayi apakati ku US amakhala ndi melasma [3].
Zadziwika kuti hyperactive melanocyte pakhungu la melasma amapanga melanin pigment yambiri kudzera mu tyrosine catabolism pathway. Tyrosinase (EC 1.14.18.1), glycoprotein yokhala ndi mkuwa, ndiye puloteni yochepetsera mlingo wofunikira kwambiri panjirayi. Kaphatikizidwe ka melanin kumachitika m'magulu apadera otchedwa melanosomes ndiyeno ma melanosomes a melanized amasamutsidwa kuchoka ku melanocyte kupita ku keratinocyte oyandikana nawo, potero zimatsimikizira mtundu wa khungu lokhazikika komanso lowoneka bwino. Zambiri zowunikira khungu zimayang'aniridwa pakuwongolera kaphatikizidwe ka melanin kudzera pakuletsa ntchito ya tyrosinase. Pazaka 50 zapitazi, hydroquinone (1, 4-benzenediol, HQ) yakhala ikugwiritsidwa ntchito kwambiri ngati mulingo wagolide wa prototypical tyrosinase inhibitors pochiza melasma. Komabe, chidwi chaposachedwapa chaperekedwa ku chiwopsezo cha thanzi chomwe chingakhalepo kwa nthawi yayitali ku HQ, monga exogenous ochronosis, leukoderma (occupational vitiligo), komanso carcinogenesis. ntchito, kupereka kuthekera kwa khungu whitening. Pakadali pano, mankhwala a monophenol awa amapangitsanso, kudzera mu enzymatic oxidation ndi tyrosinase, kukhala ndi ma free radicals ambiri omwe amayambitsa lipid peroxidation komanso kuwonongeka kwa nembanemba ya melanosomal. -pyran-2-yl) oxy] phenol, D-Arb), chochokera ku glucoside ku HQ, ndi yotetezeka komanso yocheperako ya cytotoxic poyerekeza ndi mayi ake apawiri hydroquinone. Kafukufuku wapano adachitidwa kuti afufuze za kawopsedwe ndi mphamvu ya D-Arb pamlingo wa sub-cellular (mwachindunji pa melanosomes) ndi utoto wa khungu pogwiritsa ntchito mitundu ya vivo ndi in vitro, ndikuwunikanso kutetezedwa kwa D-Arb poyerekeza ndi HQ. kugwiritsa ntchito kuyatsa khungu.
Deoxyarbutin, monga m'badwo watsopano wa zodzikongoletsera kuwala ndi whitening yogwira ntchito, makamaka ntchito zodzoladzola zapamwamba whitening.
D-Arbutin ndi imodzi mwa zotumphukira za Arbutin, zotchedwa D-nenenebb arbutin, zomwe zimatha kuletsa bwino ntchito ya tyrosinase pakhungu. Malinga ndi kafukufuku, zotsatira zake ndi 10 kuwirikiza kawiri kuposa hydroquinone ndi nthawi 350 kuposa Arbutin wamba. Poyesa khungu la nyama, D-Arbutin iyi imatha kuyeretsa khungu mwachangu komanso moyenera, ndipo ikasiya kugwiritsa ntchito, zotsatira zake zimatha kusungidwa pafupifupi milungu 8.
M'maphunziro azachipatala pathupi la munthu, kugwiritsa ntchito pamutu kwa D-Arbutin kwa milungu 12 kumatha kuwunikira kwambiri khungu, ndipo kumakhala ndi kusintha kwabwino pamawonekedwe atsiku ndi tsiku komanso mawonekedwe akhungu.
Nthawi yotumiza: Jul-11-2023
