Deoxyarbutin, a matsayin mai hana Tyrosinase mai gasa, zai iya daidaita samar da melanin, shawo kan pigmentation, fade fata baki spots, da kuma samun sauri da kuma m fata fata sakamako. Tasirin hanawa na deoxyaarbutin akan Tyrosinase a bayyane yake ya fi sauran masu kunna farar fata, kuma ana iya samun tasirin fari da haske tare da ƙaramin adadin amfani. Deoxyarbutin kuma yana da tasirin antioxidant mai ƙarfi
- Sunan Sinanci Deoxyarbutin
- Sunan waje Deoxyarbutin
- Laƙabin p - (tetrahydro-2H-pyran-2-oxy) phenol
- Tsarin sinadaran C11H14O3
- Nauyin kwayoyin 194.23
- Lambar shiga CAS 53936-56-4
- Sunan Ingilishi 4- [(Tetrahydro-2H-pyran-2-yl) oxy] phenol
- Tsafta ≥ 98%
Deoxyarbutina matsayin sabon ƙarni na kwaskwarima brightening da whitening aiki wakili, yafi amfani a ci-gaba whitening kayan shafawa.
Gwaji
Za'a iya samun daidaitawar melanogenesis a cikin melanocytes ta amfani da sinadarai waɗanda ke raba ƙa'idodin tsari tare da tyrosine na substrate kuma don haka da gasa ya hana aikin catalytic na tyrosinase. Mun ƙirƙiri sabon mai hana tyrosinase, deoxyArbutin (dA), dangane da wannan jigo. DeoxyArbutin yana nuna ingantaccen hana naman kaza tyrosinase a cikin vitro tare da Ki wanda ya ninka sau 10 ƙasa da hydroquinone (HQ) da ninki 350 ƙasa da arbutin. A cikin mara gashi, samfurin Guinea alade mai launi, dA ya nuna saurin fata mai dorewa wanda ke jujjuyawa gaba ɗaya cikin makonni 8 bayan dakatar da aikace-aikacen saman.
Sabanin haka, HQ ya haifar da gajeriyar tasirin walƙiya na fata amma kojic acid da arbutin ba su da wani tasirin walƙiya na fata. Sakamako daga kwamitin gwaje-gwajen aminci sun goyi bayan kafuwar dA gabaɗaya a matsayin kwayar halitta mai aiki. A cikin gwaji na asibiti na ɗan adam, jiyya na gida na dA na makonni 12 ya haifar da raguwa mai yawa ko kaɗan a cikin hasken fata gaba ɗaya da haɓaka lentigines na hasken rana a cikin yawan fata mai haske ko mutane masu duhu, bi da bi. Wadannan bayanan sun nuna cewa dA yana da aikin hanawa na tyrosinase wanda zai iya haifar da walƙiya na fata kuma ana iya amfani dashi don inganta raunuka na hyperpigmentary.
Gabatarwa
Melasma (chloasma) cuta ce da ta zama ruwan dare gama gari wanda ke da hasken da ba a saba da shi ba zuwa facin launin ruwan kasa a fuska, wanda yawanci yakan haifar da babban nauyi na tabin hankali ga mutanen da abin ya shafa. Duk da haka, abubuwan da ke haifar da cututtuka na melasma ba a fahimta sosai ba. Melasma ya fi kowa a cikin mutanen da ke da nau'in fata na Fitzpatrick IV zuwa VI fiye da wadanda ke da fata mai kyau (nau'i na I zuwa III). Ana kuma san cewa Melasma ya fi kowa a tsakanin mata fiye da maza kuma ya fi kowa a tsakanin Asiyawa, Latinos da Amurkawa na Afirka fiye da na Caucasians. Kimanin kashi 50 zuwa 70% na mata masu juna biyu a Amurka suna kamuwa da cutar melasma [3].
An tabbatar da cewa melanocytes na hyperactive a cikin fata na melasma suna samar da ƙarin melanin pigment ta hanyar tyrosine catabolism. Tyrosinase (EC 1.14.18.1), glycoprotein mai dauke da tagulla, shine madaidaicin adadin enzyme mai mahimmanci ga wannan hanyar. Melanin Melanin Melin da ke faruwa a cikin manyan kwararru na kwarewa ko sannan melelanosomes na Melanoocytes suna makwabta da fasaha na fata. Yawancin wakilai masu walƙiya fata suna niyya akan sarrafa haɗin melanin ta hanyar danne ayyukan tyrosinase. A cikin shekaru 50 da suka gabata, an yi amfani da hydroquinone (1, 4-benzenediol, HQ) a matsayin ma'aunin gwal don masu hana tyrosinase prototypical a cikin kula da melasma. Koyaya, an ba da hankali sosai kwanan nan ga yuwuwar haɗarin kiwon lafiya na dogon lokaci ga HQ, irin su ochronosis exogenous, leukoderma (vitiligo sana'a), har ma da carcinogenesis. aiki, yana ba da damar fata fata. A halin yanzu, waɗannan mahadi na monophenol kuma suna ba da haɓaka, ta hanyar oxidation na enzymatic ta tyrosinase, zuwa ɗimbin radicals masu yawa waɗanda ke haifar da peroxidation na lipid da sakamakon lalacewar melanosomal membrane. -pyran-2-yl) oxy] phenol, D-Arb), wanda aka samu daga glucoside. HQ, ya fi aminci kuma ƙasa da cytotoxic idan aka kwatanta da mahaɗin mahawarsa hydroquinone. An gudanar da binciken na yanzu don bincikar guba da ingancin D-Arb a matakin ƙananan salula (kai tsaye akan melanosomes) da kuma launi na fata ta amfani da in vivo da in vitro model, da kara kimanta biosafety na D-Arb a layi daya kwatanta da HQ. don amfani da walƙiya na fata.
Deoxyarbutin, a matsayin sabon ƙarni na kwaskwarima haskakawa da whitening aiki wakili, yafi amfani a ci-gaba whitening kayan shafawa.
D-Arbutin yana daya daga cikin abubuwan da aka samo na Arbutin, wanda ake kira D-nenenebb arbutin, wanda zai iya hana aikin tyrosinase sosai a cikin fata. A cewar bincike, tasirinsa ya kai ko da sau 10 na hydroquinone da sau 350 na janar Arbutin. A cikin gwaje-gwajen fata na dabba, wannan D-Arbutin na iya yin fata da sauri da inganci, kuma bayan daina amfani da shi, ana iya kiyaye tasirin har kusan makonni 8.
A cikin nazarin asibiti akan jikin mutum, yin amfani da D-Arbutin na tsawon makonni 12 zai iya cimma gagarumin tasirin walƙiya na fata, kuma yana da sakamako mai kyau na ingantawa a kan hasken hasken yau da kullum da yanayin fata mai duhu.
Lokacin aikawa: Jul-11-2023
