Deoxyarbutin, nka inhibitori ya Tyrosinase irwanya, irashobora kugenga umusaruro wa melanin, gutsinda pigmentation, gushira ibibara byumukara byuruhu, kandi bigira ingaruka zihuse kandi zirambye zo kwera uruhu. Ingaruka zo kubuza deoxyaarbutin kuri Tyrosinase biragaragara ko iruta abandi bakora ibikorwa byera, kandi ingaruka zo kwera no kumurika zirashobora kugerwaho hakoreshejwe bike. Deoxyarbutin nayo igira ingaruka zikomeye za antioxydeant
- Izina ry'igishinwa Deoxyarbutin
- Izina ry'amahanga Deoxyarbutin
- Amazina p - (tetrahydro-2H-pyran-2-oxy) phenol
- Imiti yimiti C11H14O3
- Uburemere bwa molekile 194.23
- CAS yinjira nomero 53936-56-4
- Icyongereza alias 4- [(Tetrahydro-2H-pyran-2-yl) oxy] phenol
- Isuku ≥ 98%
Deoxyarbutinnk'ibisekuru bishya byo kwisiga no kwera bikora, bikoreshwa cyane muburyo bwo kwisiga byera.
Ikizamini
Guhindura melanogenezi muri melanocytes birashobora kugerwaho ukoresheje imiti isangira homologique yubatswe hamwe na substrate tyrosine bityo bigatuma irushanwa rihagarika imikorere ya catalitiki ya tyrosinase. Twateje imbere inhibitor ya tyrosinase, deoxyArbutin (dA), dushingiye kuriyi ngingo. DeoxyArbutin yerekana uburyo bwiza bwo kubuza ibihumyo tyrosinase muri vitro hamwe na Ki iri munsi yikubye inshuro 10 hydroquinone (HQ) hamwe ninshuro 350 munsi ya arbutine. Mu ngurube y'ingurube itagira umusatsi, ifite pigmented, dA yerekanye urumuri rwihuse kandi rukomeza uruhu rwahindutse rwose mugihe cyibyumweru 8 nyuma yo guhagarara mubikorwa byingenzi.
Ibinyuranye na byo, HQ yateje uruhu rugufi ariko rudakomeye mu gihe uruhu rwa kojic na arbutine nta ngaruka zo kumurika uruhu. Ibisubizo bivuye mu itsinda ryibizamini byumutekano byashyigikiye ishyirwaho rusange rya dA nka molekile ikora. Mu igeragezwa ry’amavuriro y’abantu, kuvura indwara ya dA mu byumweru 12 byatumye igabanuka ryinshi cyangwa rito mu mucyo w’uruhu muri rusange no kunoza imirasire y’izuba ku baturage b’uruhu rworoshye cyangwa abantu bafite uruhu rwijimye. Aya makuru yerekana ko dA ifite ibikorwa bya tyrosinase byo guhagarika ibikorwa bishobora kuviramo uruhu kandi bishobora gukoreshwa mugukiza ibikomere hyperpigmentary.
Intangiriro
Melasma (chloasma) ni indwara isanzwe y’uruhu irangwa n’urumuri rudasanzwe ku ibara ryijimye mu maso, ubusanzwe bitera imitwaro ikomeye yo mu mutwe no mu mutwe ku bantu banduye. Ariko, ibintu bitera gukurura indwara ya melasma ntabwo byumvikana neza. Melasma ikunze kugaragara cyane kubantu bafite uruhu rwa Fitzpatrick IV kugeza VI kuruta abafite uruhu rwiza (ubwoko bwa I kugeza III). Melasma izwi kandi ko ikunze kugaragara mu bagore kurusha abagabo kandi ikunze kugaragara mu Banyaziya, Abalatiniya n'Abanyafurika-Abanyamerika kuruta muri Caucase. Bivugwa ko 50% kugeza 70% by'abagore batwite muri Amerika barwara melasma [3].
Byagaragaye ko hyperactive melanocytes mu ruhu rwa melasma itanga pigment nyinshi ya melanin ikoresheje inzira ya tyrosine catabolism. Tyrosinase (EC 1.14.18.1), irimo umuringa urimo glycoproteine, ni enzyme igabanya igipimo gikomeye kuri iyi nzira. Synthesis ya Melanin iboneka muri organelles yihariye cyane yitwa melanosomes hanyuma melanosomes ya melanosomes ikava muri melanocytes ikajya muri keratinocytes ituranye, bityo bikagaragaza ibara ryuruhu rwubaka kandi rufite ubushobozi. Ibikoresho byinshi byorohereza uruhu bigamije kugenzura synthesis ya melanin binyuze mu guhagarika ibikorwa bya tyrosinase. Mu myaka 50 ishize, hydroquinone (1, 4-benzenediol, HQ) yakoreshejwe cyane nk'urwego rwa zahabu kuri prototypical tyrosinase inhibitor mu kuvura melasma. Nyamara, vuba aha hibanzwe cyane ku ngaruka z’ubuzima zishobora guhura n’igihe kirekire na HQ, nka ochronose exogenous ochronose, leukoderma (vitiligo y'akazi), ndetse na kanseri .Byemewe muri rusange ko HQ ishobora kuba ari insimburangingo yo guhagarika tirozine. ibikorwa, gutanga ubushobozi bwo kwera uruhu. Hagati aho, ibyo bikoresho bya monophenol na byo bitanga imbaraga, binyuze muri okiside ya enzymatique ikorwa na tyrosinase, kuri radicals nyinshi zidegembya zitera lipide peroxidisation hamwe na melanosomal membrane yangirika .Mu bushakashatsi bwakozwe na laboratoire yacu hagaragajwe ko deoxyarbutine (4 - [(tetrahydro-2H) -pyran-2-yl) oxy] phenol, D-Arb), glucoside ikomoka kuri HQ, ifite umutekano kandi muke cytotoxic iyo ugereranije na nyina ivanze hydroquinone. Ubu bushakashatsi bwakozwe kugira ngo hakorwe iperereza ku burozi n’ingirakamaro bya D-Arb ku rwego rwa selile (mu buryo butaziguye kuri melanosomes) no gutondekanya uruhu ukoresheje vivo no muri moderi ya vitro, bikomeza gusuzuma ibinyabuzima bya D-Arb ugereranije na HQ gukoresha urumuri.
Deoxyarbutin, nk'igisekuru gishya cyo kwisiga no kwera ibintu bikora, bikoreshwa cyane muburyo bwo kwisiga byera.
D-Arbutin ni imwe mu nkomoko ya Arbutin, yitwa D-nenenebb arbutin, ishobora guhagarika neza imikorere ya tyrosinase mu ngingo z'uruhu. Nk’uko ubushakashatsi bubyerekana, ingaruka zayo zikubye inshuro 10 izo hydroquinone ndetse ninshuro 350 za Arbutin rusange. Mu gupima uruhu rwinyamaswa, iyi D-Arbutin irashobora kwera vuba kandi neza uruhu, kandi nyuma yo guhagarika ikoreshwa, ingaruka zirashobora gukomeza kumara hafi ibyumweru 8.
Mu bushakashatsi bw’amavuriro ku mubiri w’umuntu, gukoresha cyane D-Arbutin mu byumweru 12 bishobora kugera ku ngaruka zikomeye zo kumurika uruhu, kandi bigira ingaruka nziza ku rumuri rwa buri munsi hamwe n’uruhu rwijimye.
Igihe cyo kohereza: Nyakanga-11-2023
