Kodi Spermidine & nicotinamide mononucleotide (NMN) ndi chiyani?
Spermidine ndi polyamine, kutanthauza kuti ili ndi magulu awiri kapena angapo amino amino. Zimachitika mwachilengedwe ndipo zimapezeka kwambiri mu ribosomes ndi minofu yamoyo. Zimagwira ntchito yofunika kwambiri pakugwira ntchito kwa maselo komanso kukhala ndi moyo.
Spermidine inayamba kupezeka mu 1678 ndi wasayansi wachi Dutch Anton Van Leeuwenhoek mu chitsanzo cha umuna wa munthu. Posakhalitsa, spermidine anapezeka mu umuna wa munthu. M'thupi, spermidine amapangidwa kuchokera ku kalambulabwalo wake putrescine. Ndilo kalambulabwalo wa polyamine ina yotchedwa spermine, yomwe ndi yofunikanso pakugwira ntchito kwa ma cell.
Spermidine ndi putrescine amadziwika kuti amalimbikitsa autophagy. Dongosolo lomwe limaphwanya zinyalala m'maselo ndikubwezeretsanso zida zama cell. Ndi njira yofunika kwambiri yoyendetsera mitochondria, mphamvu zama cell athu. Autophagy imalola mitochondria yowonongeka kapena yolakwika kuti ithyoledwe ndikutayidwa. Kutaya kwa mitochondria kumayendetsedwa mwamphamvu kuposa momwe zimaganiziridwa kale.
Ma polyamines amatha kumangirira kumitundu yosiyanasiyana ya mamolekyu kuwapangitsa kukhala othandiza kwambiri. Amathandizira njira, kuphatikiza kukula kwa maselo, kukhazikika kwa DNA, kuchuluka kwa ma cell, ndi apoptosis [2]. Zikuwonekeranso kuti ma polyamines amagwira ntchito mofanana ndi kukula kwa zinthu panthawi ya magawano a maselo. Ichi ndichifukwa chake putrescine ndi spermidine ndizofunikira kuti minofu ikule bwino komanso kugwira ntchito.
NMN ndi mtundu wa molekyulu yotchedwa nucleotide. Ma nucleotides amagwira ntchito zambiri m'thupi lanu, kuphatikizapo kupanga DNA.
M'maselo anu, NMN imasinthidwa kukhala molekyulu ina yotchedwa nicotinamide adenine dinucleotide (NAD). Thupi lanu limafunikira NAD kuti igwire ntchito zosiyanasiyana zomwe zimakhudzidwa ndi metabolism ndi kupanga mphamvu.
Mutha kuganiza za NMN ngati zopangira komanso NAD ngati mtundu woyengedwa womwe thupi lanu lingagwiritse ntchito.
Kuchuluka kwa NAD komwe thupi lanu lingapange kumadalira kuchuluka kwa NMN komwe kulipo m'thupi lanu.
Ndi zakudya ziti zomwe zili mu spermidine &nicotinamide mononucleotide (NMN)?
Pali zakudya zambiri za spermidine kuphatikizapo mphesa, mankhwala a soya, nyemba, chimanga, mbewu zonse, nandolo, nandolo, tsabola wobiriwira, broccoli, malalanje, tiyi wobiriwira, chinangwa cha mpunga, ndi tsabola watsopano.
Zitha kupezekanso mu bowa wa shitake, njere ya amaranth, nyongolosi ya tirigu, kolifulawa, broccoli, ndi mitundu yosiyanasiyana ya tchizi okhwima, ndi durian.
Ndizofunikira kudziwa kuti zakudya zambiri zaku Mediterranean zimakhala ndi zakudya zopatsa thanzi za spermidine. Izi zitha kufotokozera zochitika za "magawo abuluu" komanso chifukwa chake anthu kumeneko amakhala nthawi yayitali kuposa kwina kulikonse.
NMN palokha ndi chinthu chomwe chili m'thupi la munthu, chomwe chili mu mkaka wa m'mawere ndi chakudya, monga edampoa, broccoli, nkhaka, kabichi, mapeyala, tomato, ndi zina zotero, koma zomwe zilipo ndizochepa kwambiri (0.25-1.88 mg pa 100 iliyonse ya 100). gramu). Ng'ombe yaiwisi ya ng'ombe ndi shrimp imakhalanso ndi zochepa kwambiri (0.06-0.42 mg pa 100 g) ya NMN.
Ubwino wa spermidine &nicotinamide mononucleotide (NMN):
Spermidine imamangiriza ku NMN, kukulitsa phindu lawo
Spermidine ndi autophagy:Spermidine imathandizanso kwambiri pazinthu zingapo zofunika zamoyo，Kukhoza kwa spermidine kuyambitsa autophagy kumaganiziridwa kuti ndiyo njira yaikulu yomwe imawoneka kuti imachepetsa ukalamba ndikuthandizira moyo wautali.
Spermidine anti-inflammatory properties:Anthu ambiri amavomereza kuti ngakhale kutupa kumathandiza pochiritsa mabala ndi kuthamangitsa tizilombo toyambitsa matenda, kutupa kosalekeza komwe kumayenderana ndi ukalamba, komwe nthawi zambiri kumatchedwa kutupa, ndikovulaza. Kutupa kosatha kumalepheretsa kusinthika kwa minofu yathanzi, kumapangitsa kuti maselo a chitetezo cha mthupi asagwire ntchito bwino, ndipo amathanso kufulumizitsa liwiro lomwe maselo athanzi amasanduka senescent. Spermidine ikuwoneka kuti imachepetsa kutupa kosatha kumeneku ndipo ingachepetse njira imodzi yomwe maselo ndi minofu imakalamba.
Spermidine ndipo imatha kuchedwetsa ukalamba:Pa moyo wautali, kutsogola kwa spermidine kwasonyezedwa kuti kumawonjezera moyo mu maphunziro angapo a zinyama ndikuletsa chiwindi fibrosis ndi hepatocellular carcinoma. Izi zikuwonekeranso kukhala momwe zilili ndi zakudya zokhala ndi ma polyamines. Palinso umboni wina wosonyeza kuti zimathandizira kukana kupsinjika maganizo komanso kuti kuchepa kwa msinkhu wa spermidine kumathandizira kuyambika kwa matenda okhudzana ndi ukalamba.
Spermidine ikhoza kuchepetsa kuchepa kwa chidziwitso:Kafukufuku yemwe adasindikizidwa mu 2021 mu nyuzipepala ya Cell Reports amafotokoza mwatsatanetsatane za zakudya za spermidine zomwe zimathandizira kuzindikira komanso kugwira ntchito kwa mitochondrial mu ntchentche ndi mbewa, ndi zina zomwe zikuyembekezeka kuti anthu aziwonjezera. Ngakhale kuti phunziroli linali losangalatsa, linali ndi zofooka zina, ndipo deta yowonjezereka yoyankha mlingo imafunika kuti chitsimikiziro chotsimikizirika chisapangidwe ponena za ubwino wa kuzindikira kwaumunthu.
Imalimbitsa Ntchito Yaubongo:NMN yawonetsedwa kuti imathandizira kuzindikira makoswe omwe ali ndi Alzheimer's komanso kuchepetsa zolembera zaubongo ndi neurodegenration mu mbewa za Alzheimer's. Ngakhale kuti Alzheimer's ndi matenda otsiriza, akuluakulu ambiri amakhalanso ndi vuto la chidziwitso - kulephera kuphunzira, kukumbukira, ndi kuganiza bwino. Kusokonezeka kwa chidziwitso chokhudzana ndi zaka zalepheretsedwa ndi NMN mu mbewa. Kusokonezeka kwachidziwitso nthawi zina kumagwirizanitsidwa ndi kuvutika maganizo, komwe kwasonyezedwanso kuti kuchepetsedwa ndi NMN mu mbewa.
Chifukwa chakuti mitsempha yathu ya magazi imakhala yosagwira ntchito tikamakalamba, magazi amapita ku ubongo wathu amawonongeka, zomwe zimatsogolera ku kusokonezeka kwa chidziwitso. NMN yasonyezedwa kuti imapangitsa kuti magazi aziyenda ku ubongo komanso kupititsa patsogolo chidziwitso cha mbewa. Mitsempha yamagazi muubongo wathu ikatsekeka, titha kukhala ndi sitiroko, yomwe minofu yathu yaubongo imawonongeka. NMN yawonetsedwa osati kungochedwetsa kuyambika kwa sitiroko, komanso kuteteza kuwonongeka kwa sitiroko, ndikuwongolera kuzindikira ndi thanzi la mitochondrial pambuyo pa sitiroko mu makoswe.
Imawonjezera Kugwira Ntchito Kwa Minofu:Timadalira minofu yathu ya chigoba kuti tiyende, kukhazikika, ndi mphamvu. Pamene tikukalamba, minofu yathu imataya mphamvu yokonzanso ndikukula, zomwe zimayambitsa kuchepa kwa msinkhu wa mphamvu ndi kukula kwa minofu yotchedwa sarcopenia. Pamodzi ndi kufooka kwa minofu, timakhalanso otopa kwambiri ndipo timakhala ndi mphamvu zochepa zakuthupi. NMN ikuwoneka kuti ikusintha mikhalidwe imeneyi, monga mmodzi wa onyamula ake asonyezedwa kuti awonjezere mphamvu ndi kupirira mwakuthupi mu mbewa.
Imalimbikitsa Mtima Wathanzi: NMN yawonetsedwa kuti imateteza kulephera kwa mtima mu mbewa. Minofu ya mtima wathu ndi yamtengo wapatali, chifukwa sichidziwika kuti imasinthika. M'malo mwake, minofu yowonongeka imawonekera m'mabala (fibrosis), zomwe zimapangitsa kuti mtima uwonongeke. NMN imabwezeretsa ntchito ya mtima wa mbewa pochepetsa mabala. Kugunda kosalekeza, mtima umafuna mphamvu zambiri. Kwa izi, pamafunika mitochondria yathanzi. NMN imathandizira kagayidwe ka mtima ndikuteteza ku kulephera kwa mtima, mwa zina mwa kubwezeretsa mitochondria.
Kuteteza Kunenepa Kwambiri ndi Matenda a Shuga:Kunenepa kwambiri kumalumikizidwa ndi kuperewera kwa kagayidwe kazakudya, kuphatikiza kukana insulini - pomwe maselo sangathe kugwiritsa ntchito shuga chifukwa cha kusazindikira kwa insulin - zomwe zingayambitse matenda a shuga. Mitochondria ndiye malo omaliza omwe amapita kuti chakudya chomwe timadya chisinthidwe kukhala mphamvu, kuwapangitsa kukhala ofunikira kwambiri mu metabolism ndi matenda okhudzana nawo. NMN yasonyezedwa kuwirikiza kawiri kuchuluka kwa mitochondria m'chiwindi cha mbewa onenepa, zomwe zingateteze ku kunenepa kwambiri. Kulimbikitsa kuwonongeka kwa mafuta ndi NMN kungathandizenso anthu onenepa kutaya mafuta.
Thandizo la NMN pa ukalamba: Miyezo ya NMN ndi NAD mwachibadwa imatsika ndi zaka, kotero ofufuza ambiri anena kuti kutenga zowonjezera za NMN kungathandize ndi nkhawa zokhudzana ndi ukalamba.
Kafukufuku wa amuna 10 aku Japan adapeza kuti kutenga NMN (100, 250, kapena 500 mg) kumawonjezera kuchuluka kwa zinthu za NMN m'magazi, kuphatikiza NAD. Insulin resistance imatha kukhala ndi ageTrusted Source ndipo ndi chimodzi mwazifukwa zomwe matenda a shuga amafala kwambiri kwa okalamba. akuluakulu. Kutenga zowonjezera za NMN kwasonyezedwanso kuchepetsa kugona ndi kupititsa patsogolo kukhudzidwa kwa minofu mwa okalamba, zomwe zingapangitse thanzi la thupi ndi maganizo ndi zaka.
Mlingo
Poganizira zochepa zomwe zilipo pakumwa zowonjezera za NMN, ndizovuta kudziwa mlingo woyenera. Kafukufuku wapeza ubwino wathanzi ndi mlingo wochepa monga 250 mg wa NMN patsiku, ndi Spermidine mlingo wa 10 - 20 mg.
Ngati mukufuna, chonde khalani omasuka kulumikizana ndi XI'AN AOGU BIOTECH !
Nthawi yotumiza: Dec-29-2022
