Iyini i-Spermidine & nicotinamide mononucleotide (NMN)?
I-Spermidine i-polyamine, okusho ukuthi inamaqembu amabili noma ngaphezulu amino ayinhloko. Kuyenzeka ngokwemvelo futhi kutholakala kabanzi kuma-ribosomes nezicubu eziphilayo. Idlala indima ebalulekile ekusebenzeni kweseli nasekuphileni kwayo.
I-Spermidine yaqala ukutholwa ngo-1678 ngusosayensi waseDashi u-Anton Van Leeuwenhoek esampula yesidoda somuntu. Ngokushesha ngemva kwalokho, kwatholakala i-spermidine esidodeni somuntu. Emzimbeni, i-spermidine idalwe kusuka ku-purescine eyandulelayo. Iyisandulela senye i-polyamine ebizwa ngokuthi i-spermine, nayo ebalulekile ekusebenzeni kwamangqamuzana.
I-Spermidine ne-purescine yaziwa ngokuvuselela i-autophagy. Isistimu ediliza udoti ngaphakathi kwamaseli futhi isebenzise kabusha izingxenye zamaselula. Kuyindlela ebalulekile yokulawula ikhwalithi ye-mitochondria, izindlu zamandla zamaseli ethu. I-Autophagy ivumela i-mitochondria eyonakele noma engasebenzi ukuthi idilizwe futhi ilahlwe. Ukulahlwa kwe-mitochondria kulawulwa ngokuqinile kunangaphambili.
Ama-polyamines angabopha ezinhlotsheni eziningi zama-molecule okwenza abe usizo kakhulu. Basekela izinqubo, okuhlanganisa ukukhula kwamaseli, ukuzinza kwe-DNA, ukwanda kwamaseli, kanye ne-apoptosis [2]. Futhi kubonakala sengathi ama-polyamines asebenza ngendlela efanayo ezicini zokukhula ngesikhathi sokuhlukaniswa kwamaseli. Yingakho i-purescine ne-spermidine ibalulekile ekukhuleni kwezicubu ezinempilo nokusebenza.
I-NMN iwuhlobo lwe-molecule ebizwa ngokuthi i-nucleotide. Ama-nucleotide adlala izindima eziningi emzimbeni wakho, okuhlanganisa nezinsimbi zokwakha ze-DNA.
Ngaphakathi kwamaseli akho, i-NMN iguqulwa ibe enye i-molecule eyaziwa ngokuthi i-nicotinamide adenine dinucleotide (NAD). Umzimba wakho udinga i-NAD ukuze wenze imisebenzi eyahlukene ehilelekile kumetabolism kanye nokukhiqizwa kwamandla.
Ungase ucabange nge-NMN njengento eluhlaza kanye ne-NAD njengenguqulo ecwengisisiwe umzimba wakho ongayisebenzisa.
Inani le-NAD elingenziwa umzimba wakho lincike enanini le-NMN elitholakala emzimbeni wakho.
Yikuphi ukudla okuku-spermidine &nicotinamide mononucleotide (NMN)?
Kunemithombo eminingi yokudla ye-spermidine ehlanganisa i-grapefruit, imikhiqizo ye-soy, i-legumes, ummbila, okusanhlamvu okuphelele, ama-chickpeas, uphizi, upelepele oluhlaza, i-broccoli, amawolintshi, itiye eliluhlaza, i-rice bran, nopelepele oluhlaza.
Ingatholakala futhi kumakhowe e-shitake, okusanhlamvu kwe-amaranth, igciwane likakolweni, ukholifulawa, i-broccoli, nezinhlobonhlobo zoshizi abavuthiwe, kanye ne-durian.
Kumele kuqashelwe ukuthi ukudla okuningi kwaseMedithera kuqukethe ukudla okucebile kwe-spermidine. Lokhu kungase okungenani kuchaze izenzakalo “zezindawo eziluhlaza okwesibhakabhaka” nokuthi kungani abantu lapho ngokuvamile bephila isikhathi eside kunezinye izindawo.
I-NMN ngokwayo iyinto equkethwe emzimbeni womuntu, ekhona obisini lwebele nokudla, njenge-edampoa, i-broccoli, ikhukhamba, iklabishi, ukwatapheya, utamatisi, njll., kodwa okuqukethwe kuncane kakhulu (0.25-1.88 mg nge-100 ngayinye). amagremu). Inyama yenkomo eluhlaza kanye nezimfanzi nazo ziqukethe amanani amancane kakhulu (0.06-0.42 mg nge-100 g) ye-NMN.
Izinzuzo ze-spermidine &nicotinamide mononucleotide (NMN):
I-Spermidine ibophezela ku-NMN, ikhulise ngempumelelo izinzuzo zayo
I-Spermidine kanye ne-autophagy:I-Spermidine nayo idlala indima ebalulekile ezinqubweni eziningi ezibalulekile zezinto eziphilayo，Ikhono le-spermidine lokuvusa i-autophagy kucatshangwa ukuthi iyindlela eyinhloko ebonakala sengathi yehlisa ijubane ukuguga futhi isekela ukuphila isikhathi eside.
I-Spermidine anti-inflammatory properties:Kwamukelwa kabanzi ukuthi nakuba ukuvuvukala kunendima ewusizo ekwelapheni kwesilonda nokuxosha amagciwane ahlaselayo, ukuvuvukala okuqhubekayo okuhlobene nokuguga, okuvame ukubizwa ngokuthi ukuvuvukala, kuyingozi. Ukuvuvukala okungapheli kuvimbela ukuvuselelwa kwezicubu ezinempilo, kubangela ukuthi amangqamuzana omzimba angasebenzi kahle, futhi kungasheshisa ngisho nesivinini lapho amangqamuzana anempilo eqala ukuphaphatheka. I-Spermidine ibonakala inciphisa lokhu kuvuvukala okungapheli futhi ingase ibambezele indlela eyodwa lapho amangqamuzana nezicubu ziguga.
I-Spermidine futhi ingase ibambezele ukuguga:Ngaphambili kokuphila isikhathi eside, ukuphathwa kwe-spermidine kuboniswe ukwandisa isikhathi sokuphila ezifundweni eziningi zezilwane futhi kuvimbele i-fibrosis yesibindi kanye ne-hepatocellular carcinoma. Lokhu kubonakala kunjalo nangokudla okucebile kuma-polyamines. Kukhona nobunye ubufakazi obubonisa ukuthi kuthuthukisa ukumelana nokucindezeleka nokuthi ukwehla okuhlobene neminyaka ye-spermidine kusekela ukuqala kwezifo ezihlobene nobudala.
I-Spermidine inganciphisa ukwehla kwengqondo:Ucwaningo olwanyatheliswa ngo-2021 kumagazini i-Cell Reports lunikeza i-akhawunti enemininingwane ye-spermidine yokudla ethuthukisa ukuqonda nokusebenza kwe-mitochondrial ezimpukaneni namagundane, ngedatha yomuntu engase ibe khona ukuyiqeda. Nakuba lolu cwaningo lwaluthakazelisa, lwalunemikhawulo ethile, futhi idatha eyengeziwe yokuphendula umthamo iyadingeka ngaphambi kokuba kuthathwe isiphetho esiqinile mayelana nezinzuzo ekuqapheliseni komuntu.
Ithuthukisa Umsebenzi Wengqondo:I-NMN ikhonjiswe ukuthi ithuthukisa ukuqonda kumagundane ane-Alzheimer's futhi yehlise ama-brain plaque kanye neurodegenration kumagundane e-Alzheimer's. Nakuba i-Alzheimer's iyisifo sokuphela, abantu abadala abaningi nabo bahlushwa ukuphazamiseka kwengqondo - ukungakwazi ukufunda, ukukhumbula, nokucabanga kahle. Lokhu kuphazamiseka kwengqondo okuhlobene neminyaka kuvinjwe i-NMN kumagundane. Ukukhubazeka kwengqondo ngezinye izikhathi kuhlotshaniswa nokucindezeleka, okuye kwaboniswa ukuthi kuncishiswe yi-NMN kumagundane.
Ngenxa yokuthi imithambo yethu yegazi iye ingasebenzi njengoba sikhula, ukugeleza kwegazi kuye ebuchosheni kuyaphazamiseka, okuholela ekulimaleni kwengqondo. I-NMN ikhonjiswe ukuthi yandisa ukugeleza kwegazi ebuchosheni futhi ithuthukise ukusebenza kwengqondo kumagundane. Lapho imithambo yegazi ebuchosheni bethu ivaleka, singaba nesifo sohlangothi, lapho izicubu zethu zobuchopho zilimale. I-NMN iye yaboniswa hhayi nje ukubambezeleka kokuqala kwe-stroke, kodwa futhi ukuvimbela ukulimala kwe-stroke, nokuthuthukisa ukuqonda nempilo ye-mitochondrial ngemva kokushaywa yi-stroke kumagundane.
Ithuthukisa Ukusebenza Kwemisipha:Sithembele emisipha yethu yamathambo ukuze sinyakaze, sizinze, namandla. Njengoba sikhula, imisipha yethu ilahlekelwa amandla ayo okuvuselela nokukhula, okuholela ekwehleni okuhlobene neminyaka emandleni emisipha nobukhulu obubizwa ngokuthi i-sarcopenia. Kanye nokuba buthakathaka kwemisipha, siphinde sikhathale futhi sibe nokukhuthazela okuncane ngokomzimba. I-NMN ibonakala ihlehlisa lezi zimo, njengoba omunye wabathuthi bayo uboniswe ukwandisa amandla nokukhuthazela ngokomzimba kumagundane.
Ikhuthaza Inhliziyo Enempilo: I-NMN ikhonjiswe ukuvikela ekuhlulekeni kwenhliziyo kumagundane. Izicubu zethu zenhliziyo ziyigugu, njengoba akwaziwa ukuthi ziyakhula. Esikhundleni salokho, izicubu ezilimele zibonakala ngezibazi (fibrosis), okuholela ekungasebenzi kahle kwenhliziyo. I-NMN ibuyisela ukusebenza kwenhliziyo yegundane ngokunciphisa izibazi. Ishaya njalo futhi njalo, inhliziyo idinga amandla amaningi. Kulokhu, kudinga i-mitochondria enempilo. I-NMN ithuthukisa umzimba wenhliziyo futhi ivikele ekuhlulekeni kwenhliziyo, ngokwengxenye ngokuvuselela i-mitochondria.
Ivikela Ukukhuluphala kanye nesifo sikashukela:Ukukhuluphala ngokweqile kuhlotshaniswa nenqwaba yokushoda kwe-metabolic, okuhlanganisa ukumelana ne-insulin - lapho amangqamuzana engakwazi ukusebenzisa i-glucose ngenxa yokungasebenzi kahle kokusayina kwe-insulin - okungaholela kushukela. I-Mitochondria iyindawo yokugcina yamangqamuzana lapho ukudla esikudlayo kuguqulwe kube amandla, okuwenza kubaluleke kakhulu kumetabolism kanye nezifo ezihlobene. I-NMN ikhonjiswe ukuthi iphinda kabili inani le-mitochondria esibindini samagundane akhuluphele, okungavikela ekukhuluphaleni. Ukukhuthaza ukuwohloka kwamafutha nge-NMN kungasiza futhi abantu abakhuluphele ukuba balahlekelwe amafutha.
Usizo lwe-NMN ngokuguga: Amazinga e-NMN kanye ne-NAD ngokwemvelo ehla ngokukhula, ngakho abacwaningi abaningi baphakamise ukuthi ukuthatha izithasiselo ze-NMN kungasiza ngokukhathazeka kwezempilo okuhlobene neminyaka.
Ucwaningo olwenziwa emadodeni angu-10 aseJapane luthole ukuthi ukuthatha i-NMN (100, 250, noma 500 mg) kwenyusa amazinga e-NMN byproducts egazini, kuhlanganise ne-NAD.Ukumelana ne-insulin kungakhula nge-ageTrusted Source futhi kungesinye sezizathu ezenza ukuthi isifo sikashukela sivame kakhulu kubantu abadala. abadala. Ukuthatha izithako ze-NMN kuye kwaboniswa ukunciphisa ukozela nokuthuthukisa ukuphendula kwemisipha kubantu abadala asebekhulile, okungase kuthuthukise kokubili impilo engokomzimba nengqondo ngeminyaka.
Umthamo
Uma kubhekwa idatha elinganiselwe etholakalayo ekuthatheni izithasiselo ze-NMN, kunzima ukunquma umthamo ofanele. Ucwaningo luye lwathola izinzuzo zezempilo ngemithamo ephansi njenge-250 mg ye-NMN ngosuku, kanye nesilinganiso se-Spermidine se-10 - 20 mg.
Uma unentshisekelo, sicela ukhululeke ukuxhumana ne-XI'AN AOGU BIOTECH !
Isikhathi sokuthumela: Dec-29-2022
