Lag luam wholesale Bulk 99% Micro Palmitoylethanolamide (PEA) hmoov
Product Description
Palmitoylethanolamide hmoov yog dab tsi?
Palmitoylethanolamide hmoov, tsim nyob rau hauv lub cev, yog ib tug natural painkiller muaj nyob rau hauv endogenous fatty acid amide qeb thiab synthesized nyob rau hauv koj lub cev.Peb hu nws endogenous.Palmitoylethanolamide pea hmoov yog siv dav hauv cov khoom noj khoom haus kis las thiab cov qauv kev noj qab haus huv sib koom ua ke thoob ntiaj teb, tshwj xeeb tshaj yog hauv Tebchaws Meskas, Australia, UK, Canada, thiab EU lub teb chaws xws li Netherlands, Belgium, thiab Ltalis.
Palmitoylethanolamide pea hmoov yog ib lo lus ntev zoo nkauj.Yog tias nws yog koj thawj zaug los hla nws, koj yuav xav paub yuav ua li cas sau lossis hais nws.Zoo, palmitoylethanolamide yog ib lo lus uas muaj peb lo lus:
Palmitoyl / pɑːmɪ'tɔɪl/ + Ethanol / 'eθənɔːl/ + Amide / 'æmɪd/
Hauv peb lub neej niaj hnub, PEA (thawj tsab ntawv ntawm txhua ntawm peb lo lus) hais txog palmitoylethanolamide luv luv.Txawm li cas los xij, PEA nws tus kheej yog cov nroj tsuag, thiab PEA cov protein kuj tseem siv rau hauv kev tsim khoom noj khoom haus raws li cov neeg tsis noj nqaij cov ntsiab lus protein.Tsis txhob ua yuam kev lawm.
PEA tau ua pov thawj los khi rau ib qho receptor nyob rau hauv lub cell nucleus (ib tug nuclear receptor) thiab exerts ib tug zoo ntau yam ntawm biological functions muaj feem xyuam rau cov mob thiab o.
Palmitoylethanolamide tshuaj muaj zog
Lub npe IUPAC ntawm PEA yog N-(2-Hydroxyethyl) hexadecanamide.Raw Palmitoylethanolamide feem ntau yog nyob rau hauv hmoov daim ntawv, nrog molecule mis nyuj thiab hnyav li C18H37NO2 thiab 299.49 feem.544-31-0 yog Palmitoylethanolamide's CAS Registry Number thiab cov cim tshuaj lom neeg.
Palmitoylethanolamide yog xyaum insoluble hauv dej thiab tsis zoo soluble nyob rau hauv feem ntau lwm cov kuab tshuaj aqueous.Yog li, koj tuaj yeem pom tias yuav luag 99% ntawm cov tshuaj tiav tiav ntawm palmitoylethanolamide yog nyob rau hauv cov tshuaj ntsiav lossis cov gels muag.
Palmitoylethanolamide VS Phenylethylamine
Qhov tseeb, lawv yog ob qho khoom xyaw sib txawv kiag li.Tsis muaj kev sib raug zoo ntawm lawv.Phenylethylamine los yog Phenylethylamine HCl yog feem ntau hu ua lub mus ob peb vas thiab poob phaus muaj nyob rau hauv ntau yam kev ua si khoom noj khoom haus.Thaum Palmitoylethanolamide hmoov yog nrov npe hu ua tshuaj tua kab mob.Qhov kev sib txuas yog tias ob lub tebchaw yog abbreviated li PEA, thiab hu ua PEA hmoov.Yog li tsis txhob yuam lawv.
Palmitoylethanolamide vs anandamide
Ntau ntawm peb cov neeg siv khoom uas yuav ntau cov hmoov palmitoylethanolamide kuj txaus siab rau Bulk anandamide hmoov thiab anandamide roj los ntawm peb.Yog li ntawd, qhov kev sib raug zoo ntawm lawv yog dab tsi?
Ob leeg Palmitoylethanolamide pea hmoov thiab anandamide yog endogenous fatty acid amides nyob rau hauv peb tib neeg lub cev.
Raws li Wikipedia, Palmitoylethanolamide PEA thiab lwm yam sib txuas xws li anandamide zoo li muaj kev sib koom ua ke hauv cov qauv ntawm qhov mob thiab kev ua xua.
Gas-chromatography/mass-spectrometry ntsuas qhia tau hais tias cov theem ntawm anandamide thiab PEA nyob rau hauv daim tawv nqaij yog txaus los ua ib tug tonic activation ntawm lub zos cannabinoid receptors.
Nyob rau hauv ib txoj kev tshawb no, cov ntaub ntawv qhia tau hais tias anandamide thiab PEA qhib pharmacologically txawv receptors thiab hais tias ob yam khoom no yuav ua tau ib txhij nyob rau hauv cov ntaub so ntswg.Thaum txhaj tshuaj ua ke hauv qhov sib npaug, anandamide thiab PEA inhibited theem pib ntawm formalin-evoked tus cwj pwm mob nrog lub zog uas yog kwv yees li 100 npaug ntau dua li txhua qhov sib xyaw sib cais (Fig. 3a).Ib qho kev sib koom ua ke zoo sib xws tau tshwm sim nyob rau theem lig, uas anandamide tsis muaj txiaj ntsig thaum muab ib leeg (Figs 1a thiab 3b).Kev tswj hwm yav dhau los ntawm CB1 lossis CB2 antagonists tag nrho thaiv cov lus teb.
Anandamide thiab PEA synergistically inhibit formalin-evoked nociception.
a, Thaum ntxov.
b, Theem lig (qhib squares, anandamide; ntim pob zeb diamond, PEA; puv lub voj voog, anandamide ntxiv rau PEA).Qhov sib npaug ntawm anandamide thiab PEA tau tswj hwm los ntawm i.pl.Kev txhaj tshuaj ntawm cov koob tshuaj qhia rau ntawm abscissa.
Tsis tas li ntawd, FAAH enzyme tuaj yeem rhuav tshem ob qho tib si anandamide thiab palmitoylethanolamide hauv lub cev.Yog tias ntxiv PEA thiab AEA hmoov ntxiv, nws yuav siv sijhawm ntau dua rau FAAH ua haujlwm thiab yog li siv sijhawm ntev dua.
Palmitoylethanolamide cov khoom noj
Qee qhov chaw ntuj pom muaj Palmitoylethanolamide.
Tej zaum koj yuav pom tias cov kua lecithin, taum pauv, qe qe, txiv laum huab xeeb (Arachis hypogaea), thiab Medicago sativa yog cov khoom noj zoo tshaj plaws.Txawm li cas los xij, qhov ntsuas qhov hnyav yog ng / g (nanogram / gram).6700 ng / g yog sib npaug rau 6.7mg / kg, txhais tau hais tias tsuas yog 6.7mg PEA yog nyob rau hauv 1 kilo ntawm soybean.Cov concentration ntawm palmitoylethanolamide hauv cov khoom noj ntuj yog tsawg dhau los ua kom tau raws li peb qhov kev xav tau niaj hnub.Txhua qhov kev lag luam xav tau yog ntau Palmitoylethanolamide, siab nyob rau hauv concentration thiab qis hauv kev tsim nqi.Aogubio science yog ib lub chaw muag khoom loj ntawm palmitoylethanolamide nyoos hmoov.Yog tias koj muaj lus nug txog PEA, tsuas yog xav tiv tauj peb.
Mechanism ntawm kev txiav txim ntawm Palmitoylethanolamide PEA
Palmitoylethanolamide PEA ua haujlwm los ntawm kev cuam tshuam ntau yam receptors ncaj qha lossis tsis ncaj, xws li PPAR-a, CB1, CB2, GPR119, GPR55, thiab lwm yam.
Palmitoylethanolamide PEA hmoov nce qib endogenous ntawm AEA (anandamide) thiab 2-AG (2-arachidonoyl-glycerol) los ntawm inhibition ntawm kev ua lossis kev qhia ntawm FAAH, lossis los ntawm cov txheej txheem tsis paub ntxiv, uas ncaj qha qhib CB2 thiab TRPV1 receptors (hloov receptors. muaj peev xwm vanilloid hom-1 channel).PEA, tejzaum nws yog los ntawm allosteric modulation ntawm TRPV1 receptors, potentiates cov kev ua ntawm AEA thiab 2-AG ntawm TRPV1 receptors.
PPAR-α thiab GPR55 yog cov receptors ncaj qha.PPAR-ib qho receptor mediates lub siab, mob, thiab neuroinflamation.PEA khi rau PPAR-ib qho receptors tsim heterodimers nrog retinoic acid receptors.Lub dimer ua raws li kev hloov pauv hloov pauv ntawm peroxisome proliferator teb cov ntsiab lus.
Kev ua kom PPAR-a ua rau muaj kev tsim tawm ntawm intracellular neurosteroids, uas hloov calcium raws thiab loj conductance potassium raws ua rau hyperpolarized neurons.Qhov no suav nrog kev ua txhaum cai ntawm PEA hauv cov qauv tsiaj.
Palmitoylethanolamide thaiv cov kev ua haujlwm ntau dhau ntawm cov hlwb mast thiab cov hlwb glial thiab rov ua haujlwm zoo li qub.Los ntawm txoj kev, Palmitoylethanolamide kuj txo cov kev ua ntawm cov pro-inflammatory enzyme COX.Muaj ntau cov txheej txheem qhia tias palmitoylethanolamide ua haujlwm li cas (teev nyob rau hauv qab ntawm nplooj ntawv no.)
Cov txiaj ntsig ntawm Palmitoylethanolamide
Palmitoylethanolamide kev noj zaub mov tsis tau raug soj ntsuam los ntawm Lub Chaw Tswj Xyuas Khoom Noj thiab Tshuaj, thiab tsis yog npaj los kuaj xyuas, kho, kho lossis tiv thaiv kab mob.Txawm li cas los xij, ntau cov khoom lag luam palmitoylethanolamide ntseeg tias nws yog npaj los kuaj xyuas thiab kho cov tshuaj tiv thaiv kab mob rau kev xav tias mob, xws li mob neuropathic.
- PEA rau Neuropathic Mob
Hauv ib qho pivotal, ob-dig muag, kev sim tshuaj placebo hauv 636 cov neeg mob sciatic mob, qhov mob hnyav tau txo qis los ntawm 50% tom qab 3 lub lis piam ntawm kev kho mob.
Tsis muaj kev cuam tshuam tshuaj los yog teeb meem tshwm sim tau piav qhia txog tam sim no.
- PEA rau kev tiv thaiv kab mob
Inflammation txhais tau tias mob.Cov txheej txheem inflammatory yog qhov tseem ceeb hauv kev loj hlob ntawm Neuropathic Mob.
Palmitoylethanolamide yog ib qho tshuaj tiv thaiv kab mob thiab txhawb kev daws teeb meem lipid tus neeg nruab nrab uas txo qis kev ua haujlwm ntawm tes thiab tswj cov cwj pwm glial cell.Qhov kev tsis sib haum xeeb ntawm cov kws kho mob pro-inflammatory thiab kev daws teeb meem qhia tau hais tias mob neuroinflammation tshwm sim.
