Wholesale Bulk 99% Micro Palmitoylethanolamide (PEA ) Poda
Product Description
Chii chinonzi Palmitoylethanolamide powder?
Palmitoylethanolamide poda, inogadzirwa mumuviri, ndeye yakasikwa painkiller musanganiswa mune endo native fatty acid amide chikamu uye yakagadzirwa mukati memuviri wako wega.Tinoti endogenous.Palmitoylethanolamide pea poda inoshandiswa zvakanyanya mumitambo yezvokudya zvinovaka muviri uye maitiro ehutano akabatana pasi rose, kunyanya muUnited States, Australia, UK, Canada, uye EU nyika dzakadai seNetherlands, Belgium, neItaly.
Palmitoylethanolamide pea poda ishoko rakanaka refu.Kana iri nguva yako yekutanga kuiona, unogona kushamisika kuti unoibata sei nemusoro kana kuidaidza.Zvakanaka, palmitoylethanolamide ishoko rine mazwi matatu:
Palmitoyl / pɑːmɪ'tɔɪl/ +Ethanol / 'eθənɔːl/ +Amide / 'æmɪd/
Muhupenyu hwedu hwezuva nezuva, PEA (tsamba yekutanga yerimwe remazwi matatu) inoreva palmitoylethanolamide kwenguva pfupi.Nekudaro, PEA pachayo chirimwa, uye puroteni yePEA inoiswawo mune zvekuvaka muviri semuriwo sosi yemapuroteni.Usavafungira zvisizvo.
PEA yakaratidzwa kuti inosunga kune receptor mu cell nucleus (nuclear receptor) uye inoshandisa zvakasiyana-siyana zvehupenyu hwehupenyu hune chokuita nekurwadziwa kusingaperi uye kuzvimba.
Palmitoylethanolamide kemikari zvivakwa
IUPAC zita rePEA ndiN-(2-Hydroxyethyl) hexadecanamide.Raw Palmitoylethanolamide inowanzo muhupfu, ine molecule formula uye uremu seC18H37NO2 uye 299.49 maererano.544-31-0 ndiyo Palmitoylethanolamide's CAS Registry Nhamba uye yakasarudzika makemikari kuzivikanwa.
Palmitoylethanolamide haigone kunyungudika mumvura uye haina kunyungudika mune mamwe akawanda aqueous solvents.Naizvozvo, iwe unogona kuona kuti ingangoita 99% yeakapedzwa dosage mafomu epalmitoylethanolamide ari mumakapisi kana akapfava gels.
Palmitoylethanolamide VS Phenylethylamine
Muchokwadi, iwo maviri akasiyana zvachose zvinhu.Hapana hukama huri pakati pavo.Phenylethylamine kana Phenylethylamine HCl inonyanya kuzivikanwa semafungiro uye uremu chigadziro mumitambo yakawanda yezvokudya.Nepo Palmitoylethanolamide poda inonyanya kuzivikanwa sepainkiller.Kubatana kwacho ndekwekuti ese ari maviri makomisheni akapfupikiswa sePEA, uye anonzi PEA poda.Saka usavafungira zvisizvo.
Palmitoylethanolamide vs anandamide
Vazhinji vevatengi vedu vanotenga yakawanda palmitoylethanolamide poda vanofarirawo Bulk anandamide poda uye anandamide mafuta kubva kwatiri.Naizvozvo, chii chiri hukama pakati pavo?
Ose ari maviri Palmitoylethanolamide pea poda uye anandamide ndiwo endo native fatty acid amides mumiviri yedu yevanhu.
Sekureva kweWikipedia, Palmitoylethanolamide PEA uye makomisheni ane hukama akadai seanandamide anoita kunge ane synergistic mhedzisiro mumhando dzemarwadzo uye analgesia.
Gas-chromatography/mass-spectrometry zviyero zvinoratidza kuti mazinga eanandamide nePEA muganda anokwana kukonzera tonic activation yemunharaunda cannabinoid receptors.
Mune imwe ongororo, iyo data inoratidza kuti anandamide nePEA activate pharmacologically distinct receptors uye kuti zvinhu zviviri izvi zvinogona kugadzirwa panguva imwe chete mumatishu.Kana yaiswa jekiseni pamwe chete mumari yakaenzana, anandamide nePEA yakadzivisa chikamu chekutanga chemaitiro ekurwadziwa kwe formalin-yakakonzera simba ne potency inenge inenge 100 yakakura kudarika imwe neimwe yezvikamu zvakasiyana (Fig. 3a).Imwe yakafanana synergistic potentiation yakaitika munguva yekupedzisira, iyo anandamide yakanga isina mhedzisiro payakapihwa yega (Figs 1a uye 3b).Kwekutanga kutonga kwevanopikisa CB1 kana CB2 kwakavharisa mhinduro.
Anandamide uye PEA synergistically inhibit formalin-evoked nociception.
a, Chikamu chekutanga.
b, Late phase (yakavhurika masikweya, anandamide; madhaimani akazadzwa, PEA; akazadzwa madenderedzwa, anandamide pamwe nePEA).Huwandu hwakaenzana hweanandamide nePEA hwakapihwa ne i.pl.Jekiseni pamadosi anoratidzwa pane abscissa.
Mukuwedzera, iyo FAAH enzyme inokwanisa kuputsa zvose anandamide uye palmitoylethanolamide mumuviri.Kana mamwe PEA uye AEA powder akawedzerwa, zvinotora nguva yakawanda kuti FAAH ishande uye nokudaro inogara kwenguva yakareba migumisiro yakanaka.
Palmitoylethanolamide chikafu masosi
Mamwe masosi masosi anowanikwa aine Palmitoylethanolamide.
Unogona kuona kuti soy lecithin, soyabhinzi, zai yolk, nzungu (Arachis hypogaea), uye Medicago sativa zviri pakati pezvepamusoro zvekudya.Nekudaro, iyo yekuverenga huremu unit ndeye ng/g (nanogram/gram).6700 ng/g yakaenzana ne6.7mg/kilo, zvichireva kuti 6.7mg PEA chete iri mukirogiramu imwe chete yesoya.Iko kusungirirwa kwepalmitoylethanolamide mukudya kwechisikigo kwakadzikira zvakanyanya kuti tisangane nezvinodiwa zvedu zvezuva nezuva.Zvese zvinodikanwa pamusika ndezvizhinji Palmitoylethanolamide, yakakwira mukusungwa uye yakaderera mumutengo wekugadzira.Aogubio sainzi mutengesi wepalmitoylethanolamide mbishi poda.Kana uine chero mibvunzo maererano nePEA, ingo sununguka kutibata.
Maitiro ekuita kwePalmitoylethanolamide PEA
Palmitoylethanolamide PEA inoshanda nekubata zvakasiyana-siyana zvinogamuchirwa zvakananga kana zvisina kunanga, sePPAR-a, CB1, CB2, GPR119, GPR55, nezvimwe.
Palmitoylethanolamide PEA powder inowedzera mazinga ekupedzisira eAEA (anandamide) uye 2-AG (2-arachidonoyl-glycerol) kuburikidza nekuvharidzirwa kwebasa kana kutaura kweFAAH, kana kuburikidza nedzimwe nzira dzisingazivikanwi, dzinoshandisa zvakananga CB2 uye TRPV1 receptors (nguva pfupi receptor. inogona vanilloid mhando-1 chiteshi).PEA, zvichida kuburikidza neallosteric modulation yeTRPV1 receptors, inogona kuita zviito zveAEA uye 2-AG paTRPV1 receptors.
PPAR-α uye GPR55 ndiwo akananga receptors.Iyo PPAR-a receptor inopindirana manzwiro, kurwadziwa, uye neuroinflammation.PEA yakasungwa kuPPAR-a receptors inoumba heterodimers ine retinoic acid receptors.Iyo dimer inoita seyakanyorwa chinhu chinosimudzira peroxisome proliferator mhinduro zvinhu.
Kuita kwePPAR-a kunowedzera kugadzirwa kwe intracellular neurosteroids, iyo inoshandura nzira dzecalcium uye hombe conductance potassium nzira inotungamira kune hyperpolarized neurons.Izvi zvinokonzeresa chiitiko chekurwisa kubatwa kwePEA mumhando dzemhuka.
Palmitoylethanolamide inovhara kuita kwakawandisa kwemaseru maseru uye glial maseru uye kudzoreredza kuita kwavo kwakajairika.Nenzira, Palmitoylethanolamide zvakare inocheka pasi basa reiyo pro-kuzvimba enzyme COX.Kune mamwe maitiro anoratidza kuti palmitoylethanolamide inoshanda sei (yakanyorwa pazasi chaipo peji ino.)
Palmitoylethanolamide Benefits
Palmitoylethanolamide dietary supplements haina kuongororwa neFood and Drug Administration, uye haina kuitirwa kuongorora, kurapa, kurapa kana kudzivirira chero chirwere.Nekudaro, akawanda palmitoylethanolamide chigadzirwa mabhureki anotenda kuti inotarisirwa kuongorora uye kurapa anti-kuzvimba marwadzo kune anofungidzirwa mamiriro ekurapa, akadai sekurwadziwa kweuropathic.
- PEA yeNeuropathic Pain
Mune imwe yakakosha, kaviri-mapofu, placebo-inodzorwa muedzo mu636 sciatic marwadzo varwere, kurwadziwa kwakanyanya kunoderedzwa zvakanyanya ne50% mushure memavhiki e3 ekurapwa.
Hapana kusangana kwezvinodhaka kana mhedzisiro inonetsa yakatsanangurwa kusvika zvino.
- PEA yechinangwa chekurwisa kuzvimba
Kuzvimba zvinoreva kurwadziwa.Iyo yekuzvimba maitiro ndeyekukosha kukuru mukuvandudzwa kweNeuropathic Pain.
Palmitoylethanolamide ndeye anti-kuzvimba uye pro-kugadzirisa lipid murevereri iyo inodzika pasi mast cell activation uye inogadzirisa glial cell maitiro.Kusawirirana kwakasimba pakati pepro-inflammatory uye pro-resolving mediators kunoratidza kuti chronic neuroinflammation iri kuitika.
