Wholesale Bulk 99% Micro Palmitoylethanolamide (PEA ) Powder
Tlhaloso ea Sehlahisoa
Palmitoylethanolamide phofo ke eng?
Palmitoylethanolamide phofo, e hlahisoang 'meleng, ke motsoako oa tlhaho oa painkiller sehlopheng sa endo native fatty acid amide mme e entsoe ka har'a' mele oa hau.Re e bitsa endogenous.Palmitoylethanolamide pea powder e sebelisoa haholo lipapaling tsa phepo ea lipapali le mekhoa e kopanetsoeng ea bophelo bo botle lefatšeng ka bophara, haholo-holo United States, Australia, UK, Canada le linaheng tsa EU tse kang Netherlands, Belgium le Italy.
Palmitoylethanolamide pea powder ke lentsoe le lelelele haholo.Haeba e le lekhetlo la pele u e fumana, u ka 'na ua ipotsa hore na u e tšoara joang ka hlooho kapa ua e bitsa joang.Hantle, palmitoylethanolamide ke lentsoe le nang le mantsoe a mararo:
Palmitoyl / pɑːmɪ'tɔɪl/ +Ethanol / 'eθənɔːl/ +Amide / 'æmɪd/
Bophelong ba rona ba letsatsi le letsatsi, PEA (tlhaku ea pele ea lentsoe le leng le le leng la mantsoe a mararo) e bua ka palmitoylethanolamide ka bokhutšoanyane.Leha ho le joalo, PEA ka boeona ke semela, 'me protheine ea PEA e boetse e sebelisoa ho li-supplement tsa ho haha' mele e le mohloli oa meroho oa protheine.O seke wa di fosa.
PEA e 'nile ea bontšoa hore e tlama ho receptor ka har'a nucleus ea sele (mokelikeli oa nyutlelie)' me e na le mesebetsi e mengata e mengata ea likokoana-hloko e amanang le bohloko bo sa foleng le ho ruruha.
Palmitoylethanolamide lik'hemik'hale
Lebitso la IUPAC la PEA ke N-(2-Hydroxyethyl) hexadecanamide.Raw Palmitoylethanolamide hangata e le phofo, e nang le foromo ea molek'hule le boima ba 'mele joaloka C18H37NO2 le 299.49 ka ho latellana.544-31-0 ke Palmitoylethanolamide's Registry Number ea CAS le boitsebiso bo ikhethang ba lik'hemik'hale.
Palmitoylethanolamide e batla e sa qhibidihe ka metsing mme ha e qhibidihe hantle ho tse ding tse ngata tse nang le metsi.Ka hona, u ka fumana hore hoo e ka bang 99% ea litlhare tse phethiloeng tsa palmitoylethanolamide li ka har'a li-capsules kapa li-gel tse bonolo.
Palmitoylethanolamide VS Phenylethylamine
Ha e le hantle, ke metsoako e 'meli e fapaneng ka ho feletseng.Ha ho na kamano pakeng tsa bona.Phenylethylamine kapa Phenylethylamine HCl e tsejoa haholo e le motsoako oa maikutlo le ho theola boima ba 'mele lijong tse ngata tsa lipapali.Le hoja phofo ea Palmitoylethanolamide e tsejoa ka ho fetisisa e le painkiller.Khokahano ke hore metsoako ka bobeli e khutsufatsoe joalo ka PEA, 'me e bitsoa phofo ea PEA.Kahoo u se ke ua ba fosetsa.
Palmitoylethanolamide vs anandamide
Boholo ba bareki ba rona ba rekang phofo e ngata ea palmitoylethanolamide le bona ba thahasella Bongata ba phofo ea anandamide le oli ea anandamide ho tsoa ho rona.Ka hona, kamano pakeng tsa bona ke efe?
Ka bobeli Palmitoylethanolamide pea powder le anandamide ke li-amide tsa mafura tse mafura 'meleng ea rona ea batho.
Ho latela Wikipedia, Palmitoylethanolamide PEA le metsoako e amanang le eona joalo ka anandamide e bonahala e na le litlamorao ho mefuta ea bohloko le analgesia.
Litekanyo tsa khase-chromatography / mass-spectrometry li bonts'a hore maemo a anandamide le PEA letlalong a lekane ho baka ts'ebetso ea tonic ea li-receptor tsa lehae tsa cannabinoid.
Phuputsong e 'ngoe, datha e bonts'a hore anandamide le PEA li kenya tšebetsong li-receptor tse fapaneng tsa pharmacologically le hore lintho tsena tse peli li ka hlahisoa ka nako e le ngoe ka har'a lisele.Ha e kenngoa hammoho ka tekanyo e lekanang, anandamide le PEA li ile tsa thibela mohato oa pele oa boitšoaro bo bohloko bo bakoang ke formalin ka potency e ka bang 100 e kholo ho feta e 'ngoe le e' ngoe ea metsoako ka thoko (Setšoantšo sa 3a).Ho na le matla a tšoanang a synergistic nakong ea morao-rao, moo anandamide e neng e se na phello ha e fanoa e le mong (Figs 1a le 3b).Tsamaiso ea pejana ea bahanyetsi ba CB1 kapa CB2 e thibetse karabelo ka botlalo.
Anandamide le PEA synergistically inhibit formalin-evoked nociception.
a, Mokhahlelo oa pele.
b, Karolo ea morao-rao (li-square tse bulehileng, anandamide; litaemane tse tletseng, PEA; li-circles tse tletseng, anandamide hammoho le PEA).Likarolo tse lekanang tsa anandamide le PEA li ne li tsamaisoa ke i.pl.Ente ka litekanyetso tse bontšitsoeng ho abscissa.
Ho phaella moo, enzyme ea FAAH e khona ho senya bobeli ba anandamide le palmitoylethanolamide 'meleng.Haeba ho eketsoa phofo e ngata ea PEA le AEA, ho tla nka nako e eketsehileng hore FAAH e sebetse 'me kahoo e tšoarelle liphello tse ntle tse telele.
Mehloli ea lijo ea Palmitoylethanolamide
Mehloli e meng ea tlhaho e fumanoa e na le Palmitoylethanolamide.
U ka hlokomela hore soy lecithin, soya, yolk ea mahe, peanut (Arachis hypogaea), le Medicago sativa ke tse ling tsa mehloli e ka sehloohong ea lijo.Leha ho le joalo, tekanyo ea boima ba ho bala ke ng/g (nanogram/gram).6700 ng/g e lekana le 6.7mg/kilo, ho bolelang hore ke 6.7mg PEA feela e leng k’hilograma e le ’ngoe ea soya.Khokahano ea palmitoylethanolamide lijong tsa tlhaho e tlase haholo ho fihlela tlhoko ea rona ea letsatsi le letsatsi.Litlhoko tsohle tsa 'maraka ke Palmitoylethanolamide e ngata, e phahameng ka ho tsepamisa maikutlo le litšenyehelo tse tlase tsa tlhahiso.Saense ea Aogubio ke mofani oa thepa e ngata ea palmitoylethanolamide phofo e tala.Haeba u na le lipotso mabapi le PEA, ikutloe u lokolohile ho ikopanya le rona.
Mokhoa oa ts'ebetso oa Palmitoylethanolamide PEA
Palmitoylethanolamide PEA e sebetsa ka ho ama li-receptor tse fapaneng ka kotloloho kapa ka tsela e sa tobang, joalo ka PPAR-a, CB1, CB2, GPR119, GPR55, jj.
Palmitoylethanolamide PEA phofo e eketsa maemo a ho qetela a AEA (anandamide) le 2-AG (2-arachidonoyl-glycerol) ka ho thibela ts'ebetso kapa polelo ea FAAH, kapa ka mekhoa e meng e sa tsejoeng, e sebetsang ka ho toba CB2 le TRPV1 receptors (motlakase oa nakoana). mocha o ka bang teng oa mofuta oa 1 oa vanilloid).PEA, mohlomong ka ho feto-fetoha ha allosteric ea li-receptor tsa TRPV1, e matlafatsa liketso tsa AEA le 2-AG ho li-receptor tsa TRPV1.
PPAR-α le GPR55 ke li-receptor tse tobileng.PPAR-a receptor e hokahanya maikutlo, bohloko le neuroinflammation.PEA e tlameletsoeng ho PPAR-a li-receptors e theha li-heterodimers tse nang le li-retinoic acid receptors.Dimer e sebetsa joalo ka mohlohlelletsi oa transcript factor ea likarolo tsa karabo ea peroxisome proliferator.
Ts'ebetso ea PPAR-a e eketsa tlhahiso ea intracellular neurosteroids, e fetolang likanale tsa calcium le likanale tse kholo tsa potasiamo tse lebisang ho li-neurone tse kholo.Sena se ikarabella bakeng sa ts'ebetso ea ho thibela ho ts'oaroa ha PEA mefuteng ea liphoofolo.
Palmitoylethanolamide e thibela ts'ebetso e feteletseng ea lisele tsa mast le lisele tsa glial mme e khutlisetsa ts'ebetso ea tsona e tloaelehileng.Ka tsela, Palmitoylethanolamide e boetse e fokotsa ts'ebetso ea enzyme ea pro-inflammatory COX.Ho na le mekhoa e meng e bonts'ang hore na palmitoylethanolamide e sebetsa joang (e thathamisitsoeng botlaaseng ba leqephe lena.)
Palmitoylethanolamide Melemo
Li-supplement tsa lijo tsa Palmitoylethanolamide ha li so hlahlojoe ke Tsamaiso ea Lijo le Lithethefatsi, 'me ha lia rereloa ho hlahloba, ho phekola, ho phekola kapa ho thibela lefu leha e le lefe.Leha ho le joalo, mefuta e mengata ea lihlahisoa tsa palmitoylethanolamide e lumela hore e reretsoe ho hlahloba le ho phekola mahlaba a anti-inflammatory bakeng sa maemo a belaelloang a bongaka, joalo ka bohloko ba neuropathic.
- PEA bakeng sa Bohloko ba Neuropathic
Tekong e le 'ngoe ea bohlokoa, e foufetseng habeli, e laoloang ke placebo ho bakuli ba bohloko ba sciatic ba 636, matla a bohloko a fokotsehile ka matla ka 50% ka mor'a libeke tsa 3 tsa phekolo.
Ha ho litšebelisano tsa lithethefatsi kapa litla-morao tse thata tse hlalositsoeng ho fihlela joale.
- PEA bakeng sa morero oa ho thibela ho ruruha
Ho ruruha ho bolela bohloko.Ts'ebetso ea ho ruruha ke ea bohlokoa haholo ho nts'etsopele ea Neuropathic Pain.
Palmitoylethanolamide ke mokena-lipakeng oa anti-inflammatory le pro-resolving lipid e hanang ts'ebetso ea mast cell le ho laola boitšoaro ba lisele tsa glial.Ho se leka-lekane ho tsitsitseng pakeng tsa bakena-lipakeng ba pro-inflammatory le pro-resolving ho bontša hore neuroinflammation e sa foleng ea etsahala.
