Iholeyili enkulu 99% Micro Palmitoylethanolamide (PEA ) Umgubo
Ingcaciso yeMveliso
Yintoni iPalmitoylethanolamide powder?
I-Palmitoylethanolamide powder, eveliswe emzimbeni, sisithako sendalo esibulala iintlungu kudidi lwe-amide ye-amide enamafutha kwaye yenziwe ngaphakathi komzimba wakho.Siyibiza ngokuba yi-endogenous.I-Palmitoylethanolamide pea powder isetyenziswa ngokubanzi kwizongezelelo zezondlo zezemidlalo kunye neefomyula zezempilo ezidibeneyo kwihlabathi jikelele, ngakumbi e-United States, e-Australia, e-UK, eCanada, nakwi-EU amazwe afana neNetherlands, iBelgium, ne-Italy.
I-Palmitoylethanolamide pea powder ligama elide kakhulu.Ukuba lixesha lakho lokuqala ukudibana nayo, unokuzibuza ukuba uyikhumbula njani okanye uyibize njani.Ewe, i-palmitoylethanolamide ligama elinamagama amathathu:
Palmitoyl / pɑːmɪ'tɔɪl/ +Ethanol / 'eθənɔːl/ +Amide / 'æmɪd/
Kubomi bethu bemihla ngemihla, i-PEA (incwadi yokuqala yegama ngalinye kumagama amathathu) ibhekisela kwi-palmitoylethanolamide ngokufutshane.Nangona kunjalo, i-PEA ngokwayo sisityalo, kwaye iprotheni ye-PEA iyasetyenziswa kwizongezelelo zokwakha umzimba njengomthombo wemifuno womxholo weprotheyini.Musa ukubaphatha kakubi.
I-PEA ibonakaliswe ukuba ibophe kwi-receptor kwi-nucleus yeseli (i-nyukliya receptor) kwaye yenza imisebenzi eyahlukeneyo yezinto eziphilayo ezinxulumene nentlungu engapheliyo kunye nokuvuvukala.
Palmitoylethanolamide iipropati zeekhemikhali
Igama le-IUPAC le-PEA yi-N-(2-Hydroxyethyl) hexadecanamide.I-Palmitoylethanolamide eluhlaza ngokuqhelekileyo i-powder form, kunye ne-molecule ye-molecule kunye nobunzima njenge-C18H37NO2 kunye ne-299.49 ngokulandelanayo.I-544-31-0 yiNombolo yeRegistry yeCAS yePalmitoylethanolamide kunye nesazisi esisodwa sekhemikhali.
I-Palmitoylethanolamide ayinakunyibilika emanzini kwaye ayinyibiliki kakuhle kuninzi lwezinye izinyibilikisi ezinamanzi.Ke ngoko, unokufumanisa ukuba phantse i-99% yokwenziwa kwedosi egqityiweyo ye-palmitoylethanolamide ikwii-capsules okanye iigels ezithambileyo.
Palmitoylethanolamide VS Phenylethylamine
Enyanisweni, zizithako ezimbini ezahlukeneyo ngokupheleleyo.Akukho budlelwane phakathi kwabo.I-Phenylethylamine okanye i-Phenylethylamine HCl iyaziwa kakhulu njengemvakalelo kunye nesithako sokulahlekelwa kwesisindo kwisondlo sezemidlalo ezininzi.Ngelixa i-Palmitoylethanolamide powder iyaziwa ngokuba yi-painkiller.Uqhagamshelwano kukuba zombini iikhompawundi zifinyeziwe njenge-PEA, kwaye zibizwa ngokuba ngumgubo we-PEA.Ngoko ke musa ukubaphatha kakubi.
Palmitoylethanolamide vs anandamide
Uninzi lwabathengi bethu abathenga isambuku sepalmitoylethanolamide powder nabo banomdla Ubuninzi be-anandamide powder kunye neoli ye-anandamide evela kuthi.Ngoko ke, yintoni ubudlelwane phakathi kwabo?
Zombini i-Palmitoylethanolamide ye-pea powder kunye ne-anandamide zii-amide ezinamafutha e-asidi emizimbeni yethu yabantu.
Ngokutsho kweWikipedia, iPalmitoylethanolamide PEA kunye neekhompawundi ezinxulumene ne-anandamide zibonakala zineempembelelo ze-synergistic kwiimodeli zentlungu kunye ne-analgesia.
Imilinganiselo yegesi-chromatography / i-mass-spectrometry ibonisa ukuba amanqanaba e-anandamide kunye ne-PEA elukhumbeni anele ukuba enze i-tonic activation ye-receptors yendawo ye-cannabinoid.
Kolunye uphononongo, idatha ibonisa ukuba i-anandamide kunye ne-PEA zenza i-pharmacologically i-receptors eyahlukileyo kwaye ezi zinto zimbini zinokuveliswa ngaxeshanye kwiithishu.Xa ijojowe kunye ngamanani alinganayo, i-anandamide kunye ne-PEA ivimbele isigaba sokuqala sokuziphatha okubuhlungu kwe-formalin-evoked nge-potency eyayimalunga ne-100 fold enkulu kuneyodwa yee-compounds ngokwahlukileyo (Umfanekiso 3a).I-synergistic potentiation efanayo yenzeke kwisigaba sokugqibela, apho i-anandamide yayingenayo impembelelo xa inikwe yodwa (iFigs 1a kunye ne-3b).Ulawulo lwangaphambili lwe-CB1 okanye i-CB2 yabachasi luthintele ngokupheleleyo impendulo.
I-Anandamide kunye ne-PEA i-synergistically inhibit formalin-evoked nociception.
a, isigaba sokuqala.
b, Isigaba samva (izikwere ezivulekileyo, i-anandamide; iidayimani ezizaliswe, i-PEA; izangqa ezizaliswe, i-anandamide kunye ne-PEA).Izixa ezilinganayo ze-anandamide kunye ne-PEA zilawulwa yi-i.pl.Isitofu kwiidosi eziboniswe kwi-abscissa.
Ukongeza, i-enzyme ye-FAAH iyakwazi ukuphula zombini i-anandamide kunye ne-palmitoylethanolamide emzimbeni.Ukuba ngaphezulu kwe-PEA kunye ne-AEA powder yongezwa, kuya kuthatha ixesha elide ukuba i-FAAH isebenze kwaye ngaloo ndlela ihlala imiphumo emihle.
Palmitoylethanolamide imithombo yokutya
Eminye imithombo yendalo ifunyenwe iqulethe iPalmitoylethanolamide.
Unokuqaphela ukuba i-soy lecithin, i-soya, i-yolk yeqanda, i-peanut (i-Arachis hypogaea), kunye ne-Medicago sativa ziphakathi kwemithombo yokutya ephezulu.Nangona kunjalo, iyunithi yobunzima bokubala ngu-ng / g (nanogram / gram).I-6700 ng/g ilingana ne-6.7mg/kilo, oku kuthetha ukuba kuphela i-6.7mg ye-PEA kwi-1 kilogram yembotyi yesoya.Ukugxininiswa kwepalmitoylethanolamide kukutya kwendalo kuphantsi kakhulu ukuhlangabezana neemfuno zethu zemihla ngemihla.Yonke imfuno yemarike sisimbuku sePalmitoylethanolamide, ephezulu ekugxininiseni kwaye ephantsi kwindleko yokuvelisa.Isayensi ye-Aogubio ngumthengisi omkhulu we-palmitoylethanolamide powder eluhlaza.Ukuba unayo nayiphi na imibuzo malunga ne-PEA, zive ukhululekile ukuqhagamshelana nathi.
Inkqubo yesenzo sePalmitoylethanolamide PEA
I-Palmitoylethanolamide PEA isebenza ngokuchaphazela i-receptors ezahlukeneyo ngokuthe ngqo okanye ngokungathanga ngqo, njenge-PPAR-a, CB1, CB2, GPR119, GPR55, njl.
I-Palmitoylethanolamide PEA powder yandisa amanqanaba angapheliyo e-AEA (anandamide) kunye ne-2-AG (2-arachidonoyl-glycerol) ngokuthintela umsebenzi okanye ukubonakaliswa kwe-FAAH, okanye ngeendlela ezongezelelweyo ezingaziwayo, ezenza ngokuthe ngqo i-CB2 kunye ne-TRPV1 i-receptors (i-receptor yesikhashana). i-vanilloid enokubakho uhlobo-1 umjelo).I-PEA, mhlawumbi ngokusebenzisa i-allosteric modulation ye-TRPV1 receptors, iyakwazi ukwenza izenzo ze-AEA kunye ne-2-AG kwi-TRPV1 receptors.
I-PPAR-α kunye ne-GPR55 zi-receptors ezithe ngqo.I-PPAR-i-receptor idibanisa imo, intlungu, kunye ne-neuroinflammation.I-PEA ebotshelelwe kwi-PPAR-i-receptors yenza i-heterodimers kunye ne-retinoic acid receptors.I-dimer isebenza njenge-transcription factor promotor ye-peroxisome proliferator response elements.
Ukusebenza kwe-PPAR-a kwandisa imveliso ye-intracellular neurosteroids, eguqula iziteshi ze-calcium kunye neendlela ezinkulu ze-potassium ezikhokelela kwii-neurons ze-hyperpolarized.Oku kubalela umsebenzi wokuchasa i-PEA kwiimodeli zezilwanyana.
I-Palmitoylethanolamide ivimba umsebenzi ogqithisileyo weeseli ze-mast kunye neeseli ze-glial kwaye zibuyisela umsebenzi wazo oqhelekileyo.Ngendlela, i-Palmitoylethanolamide ikwanciphisa umsebenzi we-enzyme ye-COX ye-pro-inflammatory.Kukho iindlela ezininzi ezibonisa indlela esebenza ngayo ipalmitoylethanolamide (ezidweliswe ezantsi kweli phepha.)
Palmitoylethanolamide Benefits
I-Palmitoylethanolamide izongezo zokutya azikavavanywa nguLawulo lokuTya kunye neDrugs, kwaye azenzelwanga ukuxilonga, ukunyanga, ukunyanga okanye ukukhusela nasiphi na isifo.Nangona kunjalo, uninzi lweemveliso zepalmitoylethanolamide zikholelwa ukuba zenzelwe ukuxilonga kunye nokunyanga iintlungu ezichasene nokudumba kweemeko zonyango ezikrokrelekayo, ezinjengeentlungu ze-neuropathic.
- I-PEA ye-Neuropathic Pain
Kwilingo elilodwa elibalulekileyo, eliphindwe kabini elingaboniyo, elilawulwa yi-placebo kwizigulane ze-636 zentlungu ye-sciatic, ubunzima bentlungu buncitshiswa kakhulu nge-50% emva kweeveki ze-3 zonyango.
Akukho ukusebenzisana kweziyobisi okanye iziphumo ebezingalindelekanga ezibi ezichaziweyo ukuza kuthi ga ngoku.
- I-PEA ngenjongo yokuchasana nokudumba
Ukudumba kuthetha intlungu.Inkqubo yokuvuvukala ibaluleke kakhulu ekuphuhliseni i-Neuropathic Pain.
I-Palmitoylethanolamide yi-anti-inflammatory kunye ne-pro-sombululo ye-lipid mediator ejika ukusebenza kweeseli ze-mast kwaye ilawule ukuziphatha kweeseli ze-glial.Ukungalingani okuzinzileyo phakathi kwabalamli be-pro-ukudumba kunye ne-pro-resolving kubonisa ukuba i-neuroinflammation engapheliyo iyenzeka.
