Kūʻai nui 99% Micro Palmitoylethanolamide (PEA) Pahu
Hōʻike huahana
He aha ka pauka Palmitoylethanolamide?
ʻO ka pauka Palmitoylethanolamide, i hana ʻia i loko o ke kino, he mea hōʻeha ʻeha maoli i loko o ka ʻāpana momona momona amide endogenous a synthesized i loko o kou kino ponoʻī.Kapa mākou he endogenous.Hoʻohana nui ʻia ʻo Palmitoylethanolamide pea pauka i nā mea hoʻohui meaʻai haʻuki a me nā ʻano olakino olakino ma ka honua holoʻokoʻa, ʻoi loa ma United States, Australia, UK, Canada, a me nā ʻāina EU e like me Netherlands, Belgium, a me Italia.
He huaʻōlelo lōʻihi loa ʻo Palmitoylethanolamide pea pauka.Inā ʻo kou manawa mua kēia e ʻike ai, noʻonoʻo paha ʻoe pehea e hoʻopaʻanaʻau ai a haʻi paha.ʻAe, ʻo ka palmitoylethanolamide kahi huaʻōlelo i loaʻa i ʻekolu mau huaʻōlelo:
Palmitoyl / pɑːmɪ'tɔɪl/ +Ethanol / 'eθənɔːl/ +Amide / 'æmɪd/
I ko mākou ola i kēlā me kēia lā, ʻo ka PEA (ka leka mua o kēlā me kēia o nā huaʻōlelo ʻekolu) pili i ka palmitoylethanolamide no ka pōkole.Eia nō naʻe, he mea kanu ka PEA ponoʻī, a ua hoʻohana pū ʻia ka protein PEA i nā mea hoʻohui bodybuilding ma ke ʻano he kumu ʻai meaʻai o ka ʻike protein.Mai kuhi hewa iā lākou.
Ua hōʻike ʻia ʻo PEA e hoʻopaʻa i kahi mea loaʻa i loko o ka cell nucleus (kahi nuklear receptor) a hoʻohana i nā ʻano hana like ʻole e pili ana i ka ʻeha mau a me ka mumū.
ʻO nā waiwai kemika Palmitoylethanolamide
ʻO ka inoa IUPAC o PEA he N-(2-Hydroxyethyl) hexadecanamide.ʻO ka lāʻau Palmitoylethanolamide ka mea maʻamau i ka pauka, me ke ʻano mole a me ke kaumaha e like me C18H37NO2 a me 299.49.ʻO 544-31-0 ka helu CAS Registry o Palmitoylethanolamide a me ka ʻike kemika kū hoʻokahi.
ʻAʻole hiki ke hoʻoheheʻe ʻia ʻo Palmitoylethanolamide i ka wai a hiki ʻole ke hoʻoheheʻe ʻia i ka hapa nui o nā mea hoʻoheheʻe wai ʻē aʻe.No laila, ʻike paha ʻoe ma kahi o 99% o ka hoʻopau ʻana i nā ʻano hana o ka palmitoylethanolamide i loko o nā capsules a i ʻole nā gela palupalu.
ʻO Palmitoylethanolamide VS Phenylethylamine
ʻO kaʻoiaʻiʻo,ʻelua mau meaʻokoʻa loa.ʻAʻohe pilina ma waena o lākou.ʻO Phenylethylamine a i ʻole Phenylethylamine HCl ka mea i ʻike nui ʻia ma ke ʻano he naʻau a me ka hoʻohaʻahaʻa kaumaha i loko o nā meaʻai haʻuki.ʻOiai ʻo Palmitoylethanolamide ka pauka i kaulana ʻia ma ke ʻano he painkiller.ʻO ka pilina, ua hoʻopau ʻia nā pūhui ʻelua e like me PEA, a kapa ʻia ʻo PEA pauda.No laila, mai kuhi hewa iā lākou.
ʻO Palmitoylethanolamide vs anandamide
ʻO ka nui o kā mākou mea kūʻai aku e kūʻai aku i ka pauka palmitoylethanolamide nui ka makemake ʻO ka pauka anandamide nui a me ka aila anandamide mai iā mākou.No laila, he aha ka pilina ma waena o lākou?
ʻO ka Palmitoylethanolamide pea pauka a me ka anandamide he endogenous fatty acid amides i loko o ko mākou kino kanaka.
Wahi a Wikipedia, ʻo Palmitoylethanolamide PEA a me nā mea pili e like me ka anandamide e like me nā hopena synergistic i nā hiʻohiʻona o ka ʻeha a me ka analgesia.
Hōʻike nā ana gas-chromatography / mass-spectrometry i nā kiʻekiʻe o ka anandamide a me ka PEA i ka ʻili e lawa ai ka hoʻoulu ʻana o ka tonic o nā mea hoʻokipa cannabinoid kūloko.
I loko o kahi noiʻi, hōʻike ka ʻikepili i ka anandamide a me ka PEA e hoʻāla i nā mea hoʻokaʻawale pharmacologically a hiki ke hana ʻia kēia mau mea ʻelua i ka manawa like i nā kiko.I ka wā i hoʻopili ʻia ai i nā helu like, ua kāohi ka anandamide a me ka PEA i ka wā mua o ka hana ʻeha i hoʻoulu ʻia e formalin me ka mana e like me ka 100 paʻi ʻoi aku ka nui ma mua o kēlā me kēia pūhui i kaʻawale (Fig. 3a).Ua like ka potentiation synergistic like i ka hopena hope, kahi i loaʻa ʻole ai ka anandamide i ka wā i hāʻawi wale ʻia (Figs 1a a me 3b).ʻO ka hoʻokele mua ʻana o ka CB1 a i ʻole CB2 antagonists i kāohi i ka pane.
ʻO Anandamide a me PEA synergistically keʻakeʻa i ka nociception-evoked formalin.
a, Māhele mua.
b, Late phase (nā ʻāpana hāmama, anandamide; nā daimana piha, PEA; nā pōʻai piha, anandamide me PEA).Ua lawelawe ʻia nā helu like o anandamide a me PEA e i.pl.Hoʻokomo ʻia ma nā ʻano i hōʻike ʻia ma ka abscissa.
Eia kekahi, hiki i ka FAAH enzyme ke wāwahi i ka anandamide a me ka palmitoylethanolamide i ke kino.Inā hoʻohui ʻia ka pauka PEA a me ka AEA, e lōʻihi ka manawa no ka FAAH e hana a no laila e lōʻihi ka hopena maikaʻi.
Nā kumu meaʻai Palmitoylethanolamide
Loaʻa kekahi mau kumu kūlohelohe i ka Palmitoylethanolamide.
E ʻike paha ʻoe i ka soy lecithin, soybean, egg yolk, peanut (Arachis hypogaea), a me Medicago sativa kekahi o nā kumu meaʻai kiʻekiʻe.Eia nō naʻe, ʻo ka helu ʻana o ke kaumaha he ng/g (nanogram/gram).Ua like ka 6700 ng/g me 6.7mg/kilo, ʻo ia hoʻi he 6.7mg PEA wale nō i loko o 1 kilo soybean.He haʻahaʻa loa ka neʻe ʻana o ka palmitoylethanolamide i nā meaʻai kūlohelohe e hoʻokō i kā mākou pono i kēlā me kēia lā.ʻO ka mākeke āpau ka nui ʻo Palmitoylethanolamide, kiʻekiʻe i ka noʻonoʻo a haʻahaʻa i ke kumukūʻai hana.ʻO ka ʻepekema Aogubio kahi mea hoʻolako nui o ka palmitoylethanolamide raw pauka.Inā he nīnau kāu e pili ana i ka PEA, e ʻoluʻolu e kelepona mai iā mākou.
Mechanism o ka hana o Palmitoylethanolamide PEA
Hana ʻia ʻo Palmitoylethanolamide PEA ma ka hoʻopili ʻana i nā mea loaʻa like ʻole a pololei ʻole paha, e like me PPAR-a, CB1, CB2, GPR119, GPR55, etc.
ʻO ka Palmitoylethanolamide PEA pauka e hoʻonui i nā pae endogenous o AEA (anandamide) a me 2-AG (2-arachidonoyl-glycerol) ma o ka pale ʻana i ka hana a i ʻole ka hōʻike ʻana o FAAH, a i ʻole ma o nā mīkini ʻike ʻole ʻē aʻe, e hoʻāla pololei i nā mea hoʻokipa CB2 a me TRPV1 (transient receptor. ʻano vanilloid type-1 channel).ʻO ka PEA, hiki paha ma o ka hoʻololi ʻana o nā mea loaʻa TRPV1, hoʻoikaika i nā hana a AEA a me 2-AG ma TRPV1 mau mea hoʻokipa.
ʻO PPAR-α a me GPR55 nā mea loaʻa pololei.Hoʻopili ka PPAR-a receptor i ke ʻano, ka ʻeha, a me ka neuroinflammation.ʻO ka PEA i hoʻopaʻa ʻia i nā mea loaʻa PPAR-a hoʻokumu i nā heterodimers me nā retinoic acid receptors.Hana ʻia ka dimer ma ke ʻano he mea hoʻolaha kumu transcription o nā mea pane pane peroxisome proliferator.
Hoʻoulu ʻia ka PPAR-a i ka hana ʻana o nā neurosteroids intracellular, e hoʻololi ana i nā kahawai calcium a me nā kahawai potassium conductance nui e alakaʻi ana i nā neurons hyperpolarized.Hōʻike kēia i ka hana antiseizure o PEA i nā ʻano holoholona.
Hoʻopaʻa ʻo Palmitoylethanolamide i ka hana nui o nā mast cell a me glial cell a hoʻihoʻi i kā lākou hana maʻamau.Ma ke ala, ʻoki ʻo Palmitoylethanolamide i ka hana o ka enzyme pro-inflammatory COX.Nui aʻe nā hana e hōʻike ana i ka hana ʻana o ka palmitoylethanolamide (i helu ʻia ma lalo o kēia ʻaoʻao.)
Nā Pōmaikaʻi Palmitoylethanolamide
ʻAʻole i loiloi ʻia nā mea hoʻohui meaʻai ʻo Palmitoylethanolamide e ka Food and Drug Administration, a ʻaʻole i manaʻo ʻia e ʻike, mālama, hoʻōla a pale i kekahi maʻi.Eia nō naʻe, manaʻo ka nui o nā huahana palmitoylethanolamide i manaʻo ʻia e hoʻopaʻa a mālama i nā ʻeha anti-inflammatory no nā kūlana olakino i manaʻo ʻia, e like me ka ʻeha neuropathic.
- PEA no ka ʻeha Neuropathic
I loko o hoʻokahi pivotal, pālua-makapō, placebo-controlled hoʻokolokolo ma 636 sciatic maʻi ʻeha, hoʻemi nui ʻia ka ʻeha e 50% ma hope o 3 mau pule o ka mālama ʻana.
ʻAʻole i wehewehe ʻia nā pilina lāʻau a i ʻole nā hopena pilikia i kēia manawa.
- PEA no ke kumu anti inflammatory
ʻO ka ʻeha ʻo ia ka ʻeha.He mea koʻikoʻi ka hana inflammatory i ka hoʻomohala ʻana o ka Neuropathic Pain.
ʻO Palmitoylethanolamide kahi mea anti-inflammatory a pro-resolving lipid mediator e hoʻohuli i ka hoʻoulu ʻana o ka mast cell a hoʻoponopono i nā ʻano o nā cell glial.ʻO ka hoʻomau ʻole ʻana ma waena o ka pro-inflammatory a me ka pro-resolving mediators e hōʻike ana e hana nei ka neuroinflammation mau.
