Igicuruzwa Cyinshi 99% Ifu ya Micro Palmitoylethanolamide (PEA)
Ibisobanuro ku bicuruzwa
Ifu ya Palmitoylethanolamide ni iki?
Ifu ya Palmitoylethanolamide, ikorerwa mu mubiri, ni ibintu bisanzwe bibabaza ububabare mu cyiciro cya endogenous fatty acide amide kandi bigashyirwa mu mubiri wawe.Tuyita endogenous.Ifu ya Palmitoylethanolamide ikoreshwa cyane mu kongera imirire ya siporo hamwe n’ubuzima bw’ubuzima ku isi hose, cyane cyane muri Amerika, Ositaraliya, Ubwongereza, Kanada, n’ibihugu by’Uburayi nk’Ubuholandi, Ububiligi, n'Ubutaliyani.
Palmitoylethanolamide ifu yamashanyarazi nijambo rirerire.Niba aribwo bwa mbere uhuye nabyo, ushobora kwibaza uburyo bwo gufata mu mutwe cyangwa kubivuga.Nibyiza, palmitoylethanolamide nijambo rigizwe namagambo atatu:
Palmitoyl / pɑːmɪ'tɔɪl / + Ethanol / 'eθənɔːl / + Amide /' æmɪd /
Mubuzima bwacu bwa buri munsi, PEA (inyuguti yambere ya buri jambo uko ari itatu) yerekeza kuri palmitoylethanolamide mugihe gito.Nyamara, PEA ubwayo ni igihingwa, kandi proteine ya PEA nayo ikoreshwa mubyongeweho byubaka umubiri nkibikomoka ku bimera bikomoka kuri poroteyine.Ntukibeshye.
PEA yerekanwe guhuza reseptor muri nucleus selile (reseptor nucleaire) kandi ikora imirimo itandukanye yibinyabuzima bijyanye n'ububabare budakira no gutwika.
Palmitoylethanolamide imiterere yimiti
IUPAC izina rya PEA ni N- (2-Hydroxyethyl) hexadecanamide.Ubusanzwe Palmitoylethanolamide iba muburyo bwa poro, hamwe na formule ya molekile nuburemere nka C18H37NO2 na 299.49.544-31-0 ni Palmitoylethanolamide ya CAS Umubare wiyandikisha hamwe nindangamuntu idasanzwe.
Palmitoylethanolamide ntigishobora gushonga mumazi kandi ntigikemuka nabi mubindi byinshi byamazi yo mumazi.Kubwibyo, ushobora gusanga hafi 99% ya dosiye yarangiye ya palmitoylethanolamide iri muri capsules cyangwa geles yoroshye.
Palmitoylethanolamide VS Phenylethylamine
Mubyukuri, nibintu bibiri bitandukanye rwose.Nta sano iri hagati yabo.Phenylethylamine cyangwa Phenylethylamine HCl izwi cyane nk'imyumvire no kugabanya ibiro mu mirire myinshi ya siporo.Mugihe ifu ya Palmitoylethanolamide izwi cyane nkumuti ubabaza.Ihuza nuko ibice byombi bigufi muri make nka PEA, kandi byitwa ifu ya PEA.Ntukibeshye rero.
Palmitoylethanolamide vs anandamide
Benshi mubakiriya bacu bagura ifu ya palmitoylethanolamide ninshi nabo barabishaka Ifu ya anandamide ninshi hamwe namavuta ya anandamide.Noneho, ni irihe sano riri hagati yabo?
Ifu ya Palmitoylethanolamide yamashanyarazi na anandamide ni aside irike ya aside irike mumibiri yacu.
Nk’uko Wikipedia ibivuga, Palmitoylethanolamide PEA hamwe nibindi bifitanye isano nka anandamide bisa nkaho bigira ingaruka zifatika muburyo bwububabare na analgesia.
Ibipimo bya gazi-chromatografiya / ibipimo bya mass-spekrometrike byerekana ko urwego rwa anandamide na PEA mu ruhu ruhagije kugirango rutere imbaraga za tonic zakira urumogi.
Mu bushakashatsi bumwe, amakuru yerekana ko anandamide na PEA bakora imiti itandukanye ya farumasi kandi ko ibyo bintu byombi bishobora gukorerwa icyarimwe mubice.Iyo batewe inshinge zingana, anandamide na PEA byabujije icyiciro cyambere cyimyitwarire yububabare buterwa na formaline hamwe nububasha bwikubye inshuro 100 kurenza buri kintu cyose gitandukanye (Ishusho 3a).Imbaraga zisa nkizo zabayeho mugice cyanyuma, aho anandamide itagize ingaruka mugihe yatanzwe wenyine (Isanamu 1a na 3b).Ubuyobozi bwambere bwaba CB1 cyangwa CB2 barwanya byanze bikunze igisubizo.
Anandamide na PEA bahujwe no kubuza nociception iterwa na formaline.
a, Icyiciro cya mbere.
b, Icyiciro cyatinze (kwaduka kwaduka, anandamide; diyama yuzuye, PEA; uruziga rwuzuye, anandamide wongeyeho PEA).Ingano ingana na anandamide na PEA byayobowe na i.pl.Gutera inshinge kuri dosiye yerekanwe kuri abscissa.
Byongeye kandi, enzyme ya FAAH ibasha kumenagura anandamide na palmitoylethanolamide mumubiri.Niba hiyongereyeho ifu ya PEA na AEA, bizatwara igihe kinini kugirango FAAH ikore bityo bimare ingaruka nziza.
Palmitoylethanolamide isoko y'ibiryo
Amasoko amwe amwe asanga arimo Palmitoylethanolamide.
Urashobora kubona ko soya lecithine, soya, umuhondo w'igi, ibishyimbo (Arachis hypogaea), na Medicago sativa biri mubisoko byambere byibiribwa.Nyamara, kubara uburemere ni ng / g (nanogram / garama).6700 ng / g ingana na 6.7mg / kilo, bivuze ko PEA 6.7mg gusa iri muri kilo 1 ya soya.Ubwinshi bwa palmitoylethanolamide mubiribwa karemano ni bike cyane kugirango duhuze ibyo dukeneye buri munsi.Isoko ryose rikeneye ni ryinshi Palmitoylethanolamide, yibanda cyane hamwe nigiciro gito cyo gukora.Siyanse ya Aogubio nisoko ryinshi rya palmitoylethanolamide ifu mbisi.Niba ufite ikibazo kijyanye na PEA, wumve neza.
Uburyo bwibikorwa bya Palmitoylethanolamide PEA
Palmitoylethanolamide PEA ikora yibasira reseptors zitandukanye muburyo butaziguye cyangwa butaziguye, nka PPAR-a, CB1, CB2, GPR119, GPR55, nibindi.
Ifu ya Palmitoylethanolamide PEA yongerera urwego rwa endogenous ya AEA (anandamide) na 2-AG (2-arachidonoyl-glycerol) binyuze mukubuza ibikorwa cyangwa imvugo ya FAAH, cyangwa hakoreshejwe ubundi buryo butazwi, butangiza byimazeyo CB2 na TRPV1 (reseptor transitive) ubushobozi bwa vanilloid ubwoko-1 umuyoboro).PEA, birashoboka binyuze muri allosteric modulation ya reseptor ya TRPV1, iha imbaraga ibikorwa bya AEA na 2-AG kubakira TRPV1.
PPAR-α na GPR55 ni reseptors itaziguye.PPAR-reseptor ihuza imyumvire, ububabare, na neuroinflammation.PEA ihambiriye kuri PPAR-yakira ikora heterodimers hamwe na reseptor aside aside.Dimer ikora nkibintu byandikirwa porotokoro ya peroxisome ikwirakwiza ibintu.
Gukora PPAR-a byongera umusaruro wa neurosteroide yo mu nda, ihindura imiyoboro ya calcium hamwe numuyoboro munini wa potasiyumu biganisha kuri neuron hyperpolarize.Ibi bibarwa kubikorwa bya antiseizure ya PEA mubyitegererezo byinyamaswa.
Palmitoylethanolamide ihagarika ibikorwa birenze urugero bya mast selile na glial selile kandi igarura ibikorwa bisanzwe.Nkuko byavuzwe, Palmitoylethanolamide nayo igabanya ibikorwa bya enzyme ya pro-inflammatory COX.Hariho ubundi buryo bwerekana uburyo palmitoylethanolamide ikora (urutonde hepfo yuru rupapuro.)
Inyungu za Palmitoylethanolamide
Ibiryo byitwa Palmitoylethanolamide ntabwo byigeze bisuzumwa n’ubuyobozi bushinzwe ibiryo n’ibiyobyabwenge, kandi ntibigamije gusuzuma, kuvura, gukiza cyangwa gukumira indwara iyo ari yo yose.Nyamara, ibicuruzwa byinshi bya palmitoylethanolamide byemeza ko bigamije gusuzuma no kuvura ububabare bwo kurwanya indwara ziterwa n’uburwayi, nk’ububabare bwa neuropathique.
- PEA kubabara Neuropathic
Mu igeragezwa rimwe rikomeye, rihumye-rihumye, rigenzurwa na platbo ku barwayi 636 barwaye ububabare bwa sciatic, ubukana bwagabanutse cyane 50% nyuma yibyumweru 3 bivurwa.
Nta mikoranire yibiyobyabwenge cyangwa ingaruka mbi zasobanuwe kugeza ubu.
- PEA hagamijwe kurwanya inflammatory
Gutwika bisobanura ububabare.Inzira yo gutwika ifite akamaro kanini mugutezimbere ububabare bwa Neuropathique.
Palmitoylethanolamide ni anti-inflammatory kandi ikemura ibibazo bya lipid mediator yanga gukora selile ya mast kandi ikagenga imyitwarire ya glial selile.Ubusumbane burambye hagati yabatera inkunga no gukemura ibibazo byerekana ko neuroinflammation idakira ibaho.
