Jumla Mai Girma 99% Micro Palmitoylethanolamide (PEA) Foda
Bayanin Samfura
Menene Palmitoylethanolamide foda?
Palmitoylethanolamide foda, wanda aka samar a cikin jiki, wani sinadari ne na maganin kashe zafi a cikin nau'in fatty acid amide na endogenous kuma yana hade cikin jikin ku.Mun kira shi endogenous.Palmitoylethanolamide pea foda ana amfani dashi sosai a cikin kayan abinci mai gina jiki na wasanni da tsarin haɗin gwiwa na kiwon lafiya a duk duniya, musamman a Amurka, Australia, UK, Kanada, da ƙasashen EU kamar Netherlands, Belgium, da Italiya.
Palmitoylethanolamide foda ce kyakkyawa doguwar kalma.Idan shine karon farko da kuka fara haduwa dashi, kuna iya mamakin yadda zaku haddace ko furta shi.To, palmitoylethanolamide kalma ce da ta ƙunshi kalmomi uku:
Palmitoyl / pɑːmɪ'tɔɪl/ +Ethanol / 'eθənɔːl/ +Amide / 'æmɪd/
A cikin rayuwarmu ta yau da kullun, PEA (harafin farko na kowane kalmomi uku) yana nufin palmitoylethanolamide a takaice.Duk da haka, PEA kanta shuka ce, kuma ana amfani da furotin na PEA a cikin abubuwan gina jiki a matsayin tushen ganyayyaki na abun ciki na furotin.Kar ku gane su ba daidai ba.
An nuna PEA don ɗaure mai karɓa a cikin kwayar halitta (mai karɓar nukiliya) kuma yana aiki da nau'o'in ayyukan ilimin halitta da suka danganci ciwo mai tsanani da kumburi.
Abubuwan sinadarai na Palmitoylethanolamide
Sunan IUPAC na PEA shine N- (2-Hydroxyethyl) hexadecanamide.Raw Palmitoylethanolamide yawanci yana cikin foda, tare da dabarar kwayoyin halitta da nauyi kamar C18H37NO2 da 299.49 bi da bi.544-31-0 shine Lambar Rijista ta CAS ta Palmitoylethanolamide da ainihin sinadarai na musamman.
Palmitoylethanolamide kusan ba ya narkewa a cikin ruwa kuma baya narkewa a yawancin sauran kaushi mai ruwa.Sabili da haka, zaku iya gano cewa kusan kashi 99% na ƙayyadaddun ƙirar ƙirar palmitoylethanolamide suna cikin capsules ko gels masu laushi.
Palmitoylethanolamide VS Phenylethylamine
A gaskiya ma, su biyu ne gaba ɗaya daban-daban sinadaran.Babu wata alaka a tsakaninsu.Phenylethylamine ko Phenylethylamine HCl an fi sani da yanayi da asarar nauyi a yawancin abincin wasanni.Yayin da Palmitoylethanolamide foda aka fi sani da maganin kashe zafi.Haɗin kai shine cewa an rage su duka mahadi kamar PEA, kuma ana kiran su PEA foda.Don haka kar a yi musu kuskure.
Palmitoylethanolamide vs anandamide
Yawancin abokan cinikinmu waɗanda ke siyan palmitoylethanolamide foda kuma suna sha'awar Bulk anandamide foda da man anandamide daga gare mu.Don haka meye alakar su?
Dukansu Palmitoylethanolamide pea foda da anandamide sune endogenous fatty acid amides a cikin jikin mu.
Bisa ga Wikipedia, Palmitoylethanolamide PEA da abubuwan da ke da alaƙa irin su anandamide suna da alama suna da tasirin daidaitawa a cikin samfuran zafi da analgesia.
Gas-chromatography / mass-spectrometry ma'auni ya nuna cewa matakan anandamide da PEA a cikin fata sun isa su haifar da kunna tonic na masu karɓar cannabinoid na gida.
A cikin binciken daya, bayanan ya nuna cewa anandamide da PEA suna kunna masu karɓa na pharmacologically kuma ana iya samar da waɗannan abubuwa guda biyu lokaci guda a cikin kyallen takarda.Lokacin da aka yi masa allura tare a daidai adadin, anandamide da PEA sun hana farkon lokaci na yanayin zafi na formalin da aka yi amfani da shi tare da karfin da ya kai kusan 100 ninka fiye da kowane mahaɗan daban (Fig. 3a).Irin wannan ƙarfin haɗin gwiwar ya faru a ƙarshen zamani, wanda anandamide ba shi da wani tasiri lokacin da aka ba shi kadai (Figs 1a da 3b).Tun da farko gudanarwa na ko dai CB1 ko CB2 antagonists gaba ɗaya sun toshe amsa.
Anandamide da PEA tare da haɗin gwiwa suna hana haɓakar nociception na formalin.
a, Farkon lokaci.
b, Late lokaci (bude murabba'ai, anandamide; lu'u-lu'u masu cika, PEA; cika da'ira, anandamide da PEA).Daidai adadin anandamide da PEA an gudanar da su ta i.pl.Allura a allurai da aka nuna akan abscissa.
Bugu da ƙari, FAAH enzyme yana iya rushe duka anandamide da palmitoylethanolamide a cikin jiki.Idan an ƙara ƙarin PEA da foda AEA, zai ɗauki ƙarin lokaci don FAAH don yin aiki kuma ta haka yana daɗaɗa tasiri mai kyau.
Palmitoylethanolamide tushen abinci
Ana samun wasu tushen halitta sun ƙunshi Palmitoylethanolamide.
Kuna iya lura cewa lecithin waken soya, waken soya, gwaiduwa kwai, gyada (Arachis hypogaea), da Medicago sativa suna cikin manyan hanyoyin abinci.Koyaya, sashin ƙididdige nauyi shine ng/g (nanogram/gram).6700 ng/g daidai yake da 6.7mg/kilo, ma'ana cewa kawai 6.7mg PEA yana cikin kilo 1 na waken soya.Matsakaicin palmitoylethanolamide a cikin abinci na halitta ya yi ƙasa da ƙasa don biyan bukatunmu na yau da kullun.Duk buƙatun kasuwa shine babban Palmitoylethanolamide, mai girma cikin maida hankali da ƙarancin ƙima.Kimiyyar Aogubio babban mai samar da palmitoylethanolamide raw foda ne.Idan kuna da wasu tambayoyi game da PEA, kawai jin daɗin tuntuɓar mu.
Hanyar aikin Palmitoylethanolamide PEA
Palmitoylethanolamide PEA yana aiki ta hanyar shafar masu karɓa daban-daban kai tsaye ko a kaikaice, kamar PPAR-a, CB1, CB2, GPR119, GPR55, da sauransu.
Palmitoylethanolamide PEA foda yana haɓaka matakan endogenous na AEA (anandamide) da 2-AG (2-arachidonoyl-glycerol) ta hanyar hana ayyukan ko magana na FAAH, ko ta hanyar ƙarin hanyoyin da ba a sani ba, waɗanda ke kunna CB2 da TRPV1 masu karɓa kai tsaye (mai karɓa na wucin gadi). yiwuwar tashar vanilloid type-1).PEA, mai yiwuwa ta hanyar daidaitawar allosteric na masu karɓar TRPV1, yana ƙarfafa ayyukan AEA da 2-AG a masu karɓar TRPV1.
PPAR-a da GPR55 masu karɓa ne kai tsaye.Mai karɓar PPAR-a yana daidaita yanayi, zafi, da neuroinflammation.PEA da ke daure zuwa PPAR-a masu karɓa suna samar da heterodimers tare da masu karɓar retinoic acid.Dimer yana aiki azaman mai tallata nau'in rubutu na abubuwan amsawar proliferator na peroxisome.
Kunna PPAR-a yana ƙaruwa da samar da ƙwayoyin neurosteroids na ciki, wanda ke canza tashoshi na calcium da manyan tashoshin potassium da ke haifar da hyperpolarized neurons.Wannan yana ba da lissafin ayyukan antiseizure na PEA a cikin ƙirar dabba.
Palmitoylethanolamide yana toshe yawan ayyukan mast da ƙwayoyin glial kuma suna dawo da ayyukansu na yau da kullun.Af, Palmitoylethanolamide kuma yana rage ayyukan da ake kira COX enzyme pro-inflammatory.Akwai ƙarin hanyoyin da ke nuna yadda palmitoylethanolamide ke aiki (wanda aka jera a ƙasan wannan shafin.)
Amfanin Palmitoylethanolamide
Palmitoylethanolamide na abinci mai gina jiki ba a tantance shi ta Hukumar Abinci da Magunguna ba, kuma ba a yi niyya don ganowa, magani, warkewa ko hana kowace cuta ba.Koyaya, yawancin samfuran samfuran palmitoylethanolamide sun yi imanin an yi niyya don tantancewa da kuma kula da radadin kumburin da ake zargi da yanayin likita, kamar ciwon neuropathic.
- PEA don Ciwon Neuropathic
A cikin mahimmancin mahimmanci, makafi biyu, gwajin gwaji na placebo a cikin 636 sciatic ciwon marasa lafiya, zafi mai tsanani yana raguwa da 50% bayan makonni 3 na jiyya.
Ba a bayyana mu'amalar magunguna ko illolin da ke tattare da matsala ba ya zuwa yanzu.
- PEA don dalilai na rigakafin kumburi
Kumburi yana nufin zafi.Tsarin kumburi yana da mahimmanci a cikin ci gaban Neuropathic Pain.
Palmitoylethanolamide mai hana kumburi ne kuma mai warware matsalar lipid matsakanci wanda ke juyar da kunna mast cell kuma yana daidaita halayen glial cell.Rashin daidaituwa mai dorewa tsakanin masu shiga tsakani na masu kumburi da masu warwarewa ya nuna cewa ciwon kumburi na kullum yana faruwa.
