I-Wholesale Bulk 99% Micro Palmitoylethanolamide (PEA ) Powder
Incazelo Yomkhiqizo
Iyini i-Palmitoylethanolamide powder?
I-Palmitoylethanolamide powder, ekhiqizwe emzimbeni, iyisithako semvelo esidambisa izinhlungu esigabeni se-endogenous fatty acid amide futhi yahlanganiswa ngaphakathi komzimba wakho. Siyibiza ngokuthi i-endogenous. I-Palmitoylethanolamide pea powder isetshenziswa kabanzi kuzithako zokudla okunomsoco wezemidlalo kanye namafomula ezempilo ahlangene emhlabeni wonke, ikakhulukazi e-United States, e-Australia, e-UK, eCanada, namazwe e-EU afana neNetherlands, Belgium, ne-Italy.
I-Palmitoylethanolamide pea powder iyigama elide kakhulu. Uma kungokokuqala ukuthi uhlangane nayo, ungase uzibuze ukuthi uyibamba kanjani ngekhanda noma uyibize kanjani. Yebo, i-palmitoylethanolamide yigama eliqukethe amagama amathathu:
Palmitoyl / pɑːmɪ'tɔɪl/ +Ethanol / 'eθənɔːl/ +Amide / 'æmɪd/
Ekuphileni kwethu kwansuku zonke, i-PEA (uhlamvu lokuqala lwegama ngalinye kwamathathu) ibhekisela ku-palmitoylethanolamide ngamafuphi. Kodwa-ke, i-PEA ngokwayo iyisitshalo, futhi iphrotheni ye-PEA isetshenziselwa izithako zokwakha umzimba njengomthombo wemifino wokuqukethwe kwamaprotheni. Ungawatholi kahle.
I-PEA iboniswe ukuthi ibophezela ku-receptor ku-nucleus yeseli (i-nuclear receptor) futhi yenza imisebenzi eminingi yezinto eziphilayo ezihlobene nobuhlungu obungapheli nokuvuvukala.
Palmitoylethanolamide chemical properties
Igama le-IUPAC le-PEA lithi N-(2-Hydroxyethyl) hexadecanamide. I-Palmitoylethanolamide eluhlaza ngokuvamile i-powder, enefomula ye-molecule nesisindo njenge-C18H37NO2 kanye ne-299.49 ngokulandelanayo. I-544-31-0 iyinombolo ye-CAS Registry ye-Palmitoylethanolamide kanye nobunikazi bamakhemikhali obuhlukile.
I-Palmitoylethanolamide ayincibiliki emanzini futhi ayincibiliki kahle kwezinye izincibilikisi ezinamanzi. Ngakho-ke, ungathola ukuthi cishe i-99% yokwakhiwa kwemithamo eqediwe ye-palmitoylethanolamide iku-capsules noma ama-gel athambile.
Palmitoylethanolamide VS Phenylethylamine
Eqinisweni, ziyizithako ezimbili ezihluke ngokuphelele. Abukho ubudlelwano phakathi kwabo. I-Phenylethylamine noma i-Phenylethylamine HCl yaziwa kakhulu njengesithako semizwa nokulahlekelwa isisindo ekudleni kwezemidlalo eminingi. Ngenkathi i-Palmitoylethanolamide powder yaziwa kakhulu ngokuthi i-painkiller. Ukuxhumana ukuthi zombili izinhlanganisela zifushaniswa njenge-PEA, futhi zibizwa nge-PEA powder. Ngakho ungawatholi kahle.
Palmitoylethanolamide vs anandamide
Amakhasimende ethu amaningi athenga ngobuningi be-palmitoylethanolamide powder nawo anentshisekelo kuwo Ubuningi be-anandamide powder namafutha e-anandamide avela kithi. Ngakho-ke, buyini ubudlelwano phakathi kwabo?
Kokubili i-Palmitoylethanolamide pea powder kanye ne-anandamide zingama-amide anamafutha acid emizimbeni yethu yabantu.
Ngokusho kwe-Wikipedia, i-Palmitoylethanolamide PEA nezinhlanganisela ezihlobene njenge-anandamide zibonakala zinemiphumela ye-synergistic kumamodeli obuhlungu kanye ne-analgesia.
Izilinganiso ze-Gas-chromatography/mass-spectrometry zibonisa ukuthi amazinga e-anandamide ne-PEA esikhumbeni anele ukuze abangele ukusebenza kwe-tonic kwama-receptors wendawo we-cannabinoid.
Kolunye ucwaningo, idatha ikhombisa ukuthi i-anandamide ne-PEA zenza kusebenze ama-receptor ahlukene ngokwemithi nokuthi lezi zinto ezimbili zingakhiqizwa kanyekanye ezicutshini. Uma ijojowe ndawonye ngamanani alinganayo, i-anandamide ne-PEA ivimbele isigaba sokuqala sokuziphatha okubuhlungu okubangelwa i-formalin nge-potency eyayicishe ibe yi-100 enkulu kuneyodwa yezinhlanganisela ngokwehlukana (Fig. 3a). Amandla afanayo e-synergistic enzeka esigabeni sekwephuzile, lapho i-anandamide ingazange ibe nomthelela lapho inikezwa iyodwa (Amakhiwane 1a kanye ne-3b). Ukuphathwa kwangaphambilini kwabaphikisi be-CB1 noma i-CB2 kuvimbe impendulo.
I-Anandamide ne-PEA zivimbela ngokuhlanganyela i-nociception ye-formalin-evoked.
a, Isigaba sokuqala.
b, Isigaba sakamuva (izikwele ezivulekile, i-anandamide; amadayimane agcwele, i-PEA; imibuthano egcwele, i-anandamide kanye ne-PEA). Amanani alinganayo e-anandamide ne-PEA alawulwa yi-i.pl. Umjovo ngemithamo ekhonjiswe ku-abscissa.
Ngaphezu kwalokho, i-enzyme ye-FAAH iyakwazi ukudiliza kokubili i-anandamide ne-palmitoylethanolamide emzimbeni. Uma i-PEA eyengeziwe ne-AEA powder yengezwa, kuzothatha isikhathi esiningi ukuze i-FAAH isebenze futhi ngaleyo ndlela ihlala isikhathi eside imiphumela emihle.
Palmitoylethanolamide imithombo yokudla
Eminye imithombo yemvelo itholakala ukuthi iqukethe i-Palmitoylethanolamide.
Ungase uqaphele ukuthi i-soy lecithin, ubhontshisi wesoya, isikhuphasha seqanda, amantongomane (i-Arachis hypogaea), ne-Medicago sativa ziphakathi kwemithombo yokudla ephezulu. Nokho, iyunithi yesisindo esibalayo yi-ng/g (nanogram/gram). 6700 ng/g ilingana no-6.7mg/kilo, okusho ukuthi i-PEA engu-6.7mg kuphela ekukhilogremu elingu-1 likabhontshisi wesoya. Ukuhlushwa kwe-palmitoylethanolamide ekudleni kwemvelo kuphansi kakhulu ukuze kuhlangatshezwane nesidingo sethu sansuku zonke. Sonke isidingo semakethe yinqwaba yePalmitoylethanolamide, esezingeni eliphezulu futhi ephansi ezindlekweni zokukhiqiza. Isayensi ye-Aogubio ingumphakeli ngobuningi be-palmitoylethanolamide powder eluhlaza. Uma unemibuzo mayelana ne-PEA, vele ukhululeke ukusithinta.
Indlela yokusebenza yePalmitoylethanolamide PEA
I-Palmitoylethanolamide PEA isebenza ngokuthinta ama-receptors ahlukahlukene ngokuqondile noma ngokungaqondile, njenge-PPAR-a, CB1, CB2, GPR119, GPR55, njll.
I-Palmitoylethanolamide PEA powder yandisa amazinga angapheli we-AEA (anandamide) kanye ne-2-AG (2-arachidonoyl-glycerol) ngokuvimbela umsebenzi noma inkulumo ye-FAAH, noma ngezinye izindlela ezingaziwa ezingaziwa, ezisebenza ngokuqondile i-CB2 ne-TRPV1 receptors (i-receptor yesikhashana Isiteshi esingaba khona se-vanilloid type-1). I-PEA, ngokunokwenzeka ngokusebenzisa i-allosteric modulation ye-TRPV1 receptors, inika amandla izenzo ze-AEA ne-2-AG kuma-receptors e-TRPV1.
I-PPAR-α ne-GPR55 ama-receptors aqondile. I-PPAR-a receptor ilamula imizwa, ubuhlungu, kanye ne-neuroinflammation. I-PEA eboshelwe ku-PPAR-a ama-receptors enza ama-heterodimers ane-retinoic acid receptors. I-dimer isebenza njengomgqugquzeli wesici sokuloba sezinto zokuphendula ze-peroxisome proliferator.
Ukusebenza kwe-PPAR-a kukhulisa ukukhiqizwa kwe-intracellular neurosteroids, eshintsha iziteshi ze-calcium kanye neziteshi ezinkulu ze-potassium eziholela kuma-neuron e-hyperpolarized. Lokhu kubala umsebenzi we-PEA wokulwa nokubanjwa yimizwa kumamodeli ezilwane.
I-Palmitoylethanolamide ivimba umsebenzi oweqile wamaseli e-mast namaseli e-glial futhi ibuyisela umsebenzi wawo ojwayelekile. Ngendlela, i-Palmitoylethanolamide iphinde yehlise umsebenzi we-enzyme ye-pro-inflammatory COX. Kunezindlela eziningi ezibonisa ukuthi i-palmitoylethanolamide isebenza kanjani (ebhalwe phansi phansi kwaleli khasi.)
Palmitoylethanolamide Izinzuzo
Izithako zokudla ze-Palmitoylethanolamide azikahlolwa yi-Food and Drug Administration, futhi azihloselwe ukuxilonga, ukwelapha, ukwelapha noma ukuvimbela noma yisiphi isifo. Kodwa-ke, izinhlobo eziningi zomkhiqizo we-palmitoylethanolamide zikholelwa ukuthi kuhloswe ngazo ukuxilonga nokwelapha izinhlungu zokulwa nokuvuvukala kwezimo zezokwelapha ezisolwayo, njengobuhlungu be-neuropathic.
- I-PEA ye-Neuropathic Pain
Esivivinyweni esisodwa esibalulekile, esiyimpumputhe esiphindwe kabili, esilawulwa yi-placebo ezigulini ezibuhlungu ze-sciatic ze-636, ukuqina kobuhlungu kuncishiswa kakhulu nge-50% ngemva kwamasonto e-3 yokwelashwa.
Akukho ukusebenzisana kwezidakamizwa noma imiphumela emibi enzima echazwe kuze kube manje.
- I-PEA ngenjongo yokulwa nokuvuvukala
Ukuvuvukala kusho ubuhlungu. Inqubo yokuvuvukala ibaluleke kakhulu ekuthuthukisweni kwe-Neuropathic Pain.
I-Palmitoylethanolamide ingumxhumanisi we-lipid ophikisana nokuvuvukala futhi oxazulula pro-evala ukusebenza kwe-mast cell futhi ilawule ukuziphatha kwe-glial cell. Ukungalingani okuqhubekayo phakathi kwabaxazululi be-pro-inflammatory kanye ne-pro-resolving kubonisa ukuthi i-neuroinflammation engapheli iyenzeka.
