Nnukwu nnukwu 99% Micro Palmitoylethanolamide (PEA) ntụ ntụ

Kedu ihe bụ Palmitoylethanolamide ntụ ntụ?

Palmitoylethanolamide ntụ ntụ, nke emepụtara n'ime ahụ, bụ ihe na-egbu mgbu sitere n'okike n'ụdị fatty acid amide endogenous ma mekwaa n'ime ahụ gị.Anyị na-akpọ ya endogenous.A na-etinye ntụ ntụ Palmitoylethanolamide n'ọtụtụ ebe na mgbakwunye nri nri egwuregwu yana usoro ahụike nkwonkwo n'ụwa niile, ọkachasị na United States, Australia, UK, Canada, na mba EU dị ka Netherlands, Belgium, na Italy.

Palmitoylethanolamide ntụ ntụ bụ ezigbo ogologo okwu.Ọ bụrụ na ọ bụ nke mbụ ị ga-ahụ ya, ị nwere ike ịnọ na-eche ka esi eburu ya n'isi ma ọ bụ kpọọ ya.Ọfọn, palmitoylethanolamide bụ okwu nwere mkpụrụokwu atọ:

Palmitoyl / pɑːmɪ'tɔɪl/ +Ethanol / 'eθənɔːl/ +Amide / 'æmɪd/

Na ndụ anyị kwa ụbọchị, PEA (akwụkwọ ozi mbụ nke ọ bụla n'ime okwu atọ) na-ezo aka na palmitoylethanolamide maka mkpụmkpụ.Otú ọ dị, PEA n'onwe ya bụ osisi, a na-etinyekwa protein PEA n'ime ihe mgbakwunye anụ ahụ dị ka isi iyi protein ndị anaghị eri anụ.Aghọtala ha ihe ọjọọ.

E gosipụtara PEA iji jikọta onye na-anabata ya na cell cell (onye na-anabata ihe nuklia) ma na-arụ ọrụ dịgasị iche iche nke ndụ metụtara mgbu na mgbu na-adịghị ala ala.

Njirimara chemical Palmitoylethanolamide

Aha IUPAC nke PEA bụ N- (2-Hydroxyethyl) hexadecanamide.Raw Palmitoylethanolamide na-abụkarị n'ụdị ntụ ntụ, yana usoro molecule na ịdị arọ dị ka C18H37NO2 na 299.49 n'otu n'otu.544-31-0 bụ Nọmba Ndekọ CAS nke Palmitoylethanolamide na njirimara kemịkal pụrụ iche.

Palmitoylethanolamide bụ ihe a na-adịghị ahụkebe na mmiri, ọ naghị esikwa ya ike n'ọtụtụ ihe mgbaze mmiri ndị ọzọ.Ya mere, ị nwere ike ịchọpụta na ihe fọrọ nke nta ka ọ bụrụ 99% nke usoro ọgwụgwọ palmitoylethanolamide emechara dị na capsules ma ọ bụ gels dị nro.

Palmitoylethanolamide VS Phenylethylamine

N'ezie, ha bụ ihe abụọ dị iche iche.Ọ dịghị mmekọrịta dị n'etiti ha.Phenylethylamine ma ọ bụ Phenylethylamine HCl bụ ihe a kacha mara amara dị ka ihe mmetụta uche na mbelata ibu n'ọtụtụ nri egwuregwu.Ọ bụ ezie na Palmitoylethanolamide ntụ ntụ bụ nke a maara nke ọma dị ka ihe mgbu.Njikọ ahụ bụ na a na-ebelata ogige abụọ ahụ dị ka PEA, ma kpọọ PEA ntụ ntụ.Ya mere, aghọtala ha.

Palmitoylethanolamide vs anandamide

Ọtụtụ n'ime ndị ahịa anyị na-azụta nnukwu palmitoylethanolamide ntụ ntụ nwekwara mmasị Nnukwu anandamide ntụ ntụ na mmanụ anandamide sitere na anyị.Ya mere, olee ihe jikọrọ ha?

Ma Palmitoylethanolamide pea ntụ ntụ na anandamide bụ endogenous fatty acid amides na ahụ mmadụ anyị.

Dị ka Wikipedia si kwuo, Palmitoylethanolamide PEA na ogige ndị metụtara ya dị ka anandamide yiri ka ọ nwere mmetụta synergistic na ụdị mgbu na analgesia.

Gas-chromatography / mass-spectrometry nha na-egosi na ọkwa nke anandamide na PEA na akpụkpọ ahụ zuru ezu iji mee ka ọrụ tonic nke ndị na-anabata cannabinoid mpaghara.

N'otu nnyocha, data na-egosi na anandamide na PEA na-eme ka ndị na-anabata ọgwụ dị iche iche na-emepụta ọgwụ na-emepụta ihe abụọ a n'otu oge na anụ ahụ.Mgbe a na-agbanye ọnụ n'otu nha nha, anandamide na PEA gbochiri mmalite mmalite nke omume mgbu nke formalin na-akpata site na ike nke dị ihe dị ka 100 okpukpu karịa nke ọ bụla n'ime ogige ndị dị iche iche (Fig 3a).Otu ike nke synergistic yiri nke ahụ mere na njedebe oge, nke anandamide enweghị mmetụta mgbe e nyere naanị ya (Figs 1a na 3b).Nlekọta mbụ nke CB1 ma ọ bụ CB2 antagonists gbochiri nzaghachi ahụ kpamkpam.

Anandamide na PEA synergistically na-egbochi nociception nke formalin.

a, Oge mmalite.

b, Oge ngwụcha (oghere mepere emepe, anandamide; diamond jupụtara, PEA; okirikiri jupụtara, anandamide gbakwunyere PEA).Anandamide nha nhata na PEA bụ ndị i.pl na-elekọta.Ịgba ọgwụ na doses egosiri na abscissa.

Na mgbakwunye, FAAH enzyme nwere ike imebi ma anandamide na palmitoylethanolamide n'ime ahụ.Ọ bụrụ na agbakwunyere PEA na ntụ ntụ AEA, ọ ga-ewekwu oge maka FAAH na-arụ ọrụ ma si otú ahụ na-adịru ogologo oge mmetụta dị mma.