Ufa Wochuluka 99% Micro Palmitoylethanolamide (PEA )
Mafotokozedwe Akatundu
Kodi Palmitoylethanolamide powder ndi chiyani?
Palmitoylethanolamide ufa, wopangidwa m'thupi, ndi mankhwala opha ululu m'gulu lamafuta acid amide ndipo amapangidwa mkati mwa thupi lanu.Timachitcha kuti endogenous.Palmitoylethanolamide ufa wa nandolo umagwiritsidwa ntchito kwambiri pazakudya zopatsa thanzi komanso njira zolumikizirana zaumoyo padziko lonse lapansi, makamaka ku United States, Australia, UK, Canada, ndi mayiko a EU monga Netherlands, Belgium, ndi Italy.
Palmitoylethanolamide pea ufa ndi mawu otalika kwambiri.Ngati ndi nthawi yanu yoyamba kuzipeza, mutha kudabwa momwe mungalowere kapena kuzitchulira.Chabwino, palmitoylethanolamide ndi mawu omwe ali ndi mawu atatu:
Palmitoyl / pɑːmɪ'tɔɪl/ +Ethanol / 'eθənɔːl/ +Amide / 'æmɪd/
M'moyo wathu watsiku ndi tsiku, PEA (chilembo choyamba cha mawu atatu aliwonse) chimatanthawuza palmitoylethanolamide mwachidule.Komabe, PEA palokha ndi chomera, ndipo mapuloteni a PEA amagwiritsidwanso ntchito muzowonjezera zomanga thupi monga gwero lazamasamba la mapuloteni.Osawalakwitsa.
PEA yasonyezedwa kuti imamangiriza ku receptor mu cell nucleus (nyukiliya receptor) ndipo imakhala ndi ntchito zosiyanasiyana zamoyo zokhudzana ndi kupweteka kosalekeza ndi kutupa.
Palmitoylethanolamide mankhwala katundu
Dzina la IUPAC la PEA ndi N-(2-Hydroxyethyl) hexadecanamide.Palmitoylethanolamide yaiwisi yaiwisi nthawi zambiri imakhala mu mawonekedwe a ufa, yokhala ndi mamolekyu ndi kulemera kwake monga C18H37NO2 ndi 299.49 motsatira.544-31-0 ndi Palmitoylethanolamide's Registry Number ya CAS ndi chidziwitso chapadera cha mankhwala.
Palmitoylethanolamide imakhala yosasungunuka m'madzi ndipo imasungunuka bwino muzosungunulira zina zambiri zamadzi.Chifukwa chake, mutha kupeza kuti pafupifupi 99% yamankhwala omaliza a palmitoylethanolamide ali mu makapisozi kapena ma gels ofewa.
Palmitoylethanolamide VS Phenylethylamine
Ndipotu, ndi zinthu ziwiri zosiyana kwambiri.Palibe ubale pakati pawo.Phenylethylamine kapena Phenylethylamine HCl imadziwika kwambiri ngati kusinthasintha komanso kuchepa thupi pazakudya zambiri zamasewera.Ngakhale Palmitoylethanolamide ufa amadziwika kuti ndi painkiller.Kulumikizana ndiko kuti mankhwala onsewa amafupikitsidwa ngati PEA, ndipo amatchedwa PEA powder.Choncho musawalakwitse.
Palmitoylethanolamide vs anandamide
Makasitomala athu ambiri omwe amagula ufa wochuluka wa palmitoylethanolamide nawonso ali ndi chidwi Ufa wambiri wa anandamide ndi mafuta a anandamide kuchokera kwa ife.Chifukwa chake, pali ubale wotani pakati pawo?
Onse a Palmitoylethanolamide nandolo ufa ndi anandamide ndi endogenous fatty acid amides m'matupi athu aumunthu.
Malinga ndi Wikipedia, Palmitoylethanolamide PEA ndi mankhwala ofananirako monga anandamide amawoneka kuti ali ndi zotsatira za synergistic mumitundu ya zowawa ndi analgesia.
Miyezo ya gas-chromatography/mass-spectrometry ikuwonetsa kuti milingo ya anandamide ndi PEA pakhungu ndiyokwanira kuyambitsa kuyatsa kwa ma cannabinoid receptors amderalo.
Pakafukufuku wina, deta ikuwonetsa kuti anandamide ndi PEA amatsegula ma receptor osiyana ndi mankhwala komanso kuti zinthu ziwirizi zitha kupangidwa nthawi imodzi m'magulu.Pamene jekeseni pamodzi muyeso yofanana, anandamide ndi PEA analetsa gawo loyambirira la khalidwe lopweteka la formalin ndi potency yomwe inali pafupifupi 100 yochuluka kuposa mankhwala aliwonse payekha (mkuyu 3a).Mphamvu yofananira yofananira idachitika kumapeto kwa gawo, pomwe anandamide analibe mphamvu atapatsidwa yekha (Figs 1a ndi 3b).Kuwongolera koyambirira kwa otsutsa a CB1 kapena CB2 kudalepheretsa kuyankha.
Anandamide ndi PEA synergistically inhibit formalin-evoked nociception.
a, Gawo loyamba.
b, Mochedwa gawo (mabwalo otseguka, anandamide; diamondi zodzaza, PEA; mabwalo odzaza, anandamide kuphatikiza PEA).Zofanana za anandamide ndi PEA zidayendetsedwa ndi i.pl.Jekeseni pa Mlingo wasonyezedwa pa abscissa.
Kuonjezera apo, puloteni ya FAAH imatha kusokoneza anandamide ndi palmitoylethanolamide m'thupi.Ngati zambiri za PEA ndi AEA ufa zikuwonjezeredwa, zidzatenga nthawi yochuluka kuti FAAH igwire ntchito ndipo motero imakhala ndi zotsatira zabwino.
Zakudya za Palmitoylethanolamide
Zina mwachilengedwe zimapezeka kuti zili ndi Palmitoylethanolamide.
Mutha kuzindikira kuti soya lecithin, soya, yolk ya dzira, mtedza (Arachis hypogaea), ndi Medicago sativa ndi zina mwazakudya zapamwamba.Komabe, gawo lowerengera kulemera ndi ng/g (nanogram/gram).6700 ng/g ndi wofanana ndi 6.7mg/kilo, kutanthauza kuti 6.7mg PEA yokha ili mu kilogalamu imodzi ya soya.Kuchuluka kwa palmitoylethanolamide muzakudya zachilengedwe ndikotsika kwambiri kuti tikwaniritse zosowa zathu zatsiku ndi tsiku.Zomwe zimafunikira pamsika ndizochuluka Palmitoylethanolamide, zokhazikika komanso zotsika mtengo wopanga.Sayansi ya Aogubio ndiwopereka zambiri za palmitoylethanolamide ufa waiwisi.Ngati muli ndi mafunso okhudzana ndi PEA, ingomasukani kulankhula nafe.
Njira ya zochita za Palmitoylethanolamide PEA
Palmitoylethanolamide PEA imagwira ntchito pokhudza ma receptor osiyanasiyana mwachindunji kapena mwanjira ina, monga PPAR-a, CB1, CB2, GPR119, GPR55, etc.
Palmitoylethanolamide PEA powder imawonjezera ma AEA (anandamide) ndi 2-AG (2-arachidonoyl-glycerol) kupyolera mu kulepheretsa ntchito kapena mawu a FAAH, kapena kudzera mu njira zina zosadziwika bwino, zomwe zimayambitsa mwachindunji CB2 ndi TRPV1 zolandilira (zolandira zosakhalitsa). kuthekera kwa vanilloid mtundu-1 njira).PEA, mwinamwake kupyolera mu allosteric modulation ya TRPV1 zolandilira, potentiate zochita za AEA ndi 2-AG pa TRPV1 zolandilira.
PPAR-α ndi GPR55 ndi zolandilira mwachindunji.PPAR-a receptor imayanjanitsa malingaliro, ululu, ndi neuroinflammation.PEA yomangidwa ku PPAR-a receptors amapanga ma heterodimers okhala ndi retinoic acid receptors.Dimer imagwira ntchito ngati transcript factor proliferator ya peroxisome proliferator reaction elements.
Kutsegula kwa PPAR-a kumawonjezera kupanga kwa intracellular neurosteroids, yomwe imasintha njira za calcium ndi njira zazikulu za potaziyamu zomwe zimatsogolera ku hyperpolarized neurons.Izi zimachititsa kuti PEA ikhale yotsutsana ndi kugwidwa kwa nyama.
Palmitoylethanolamide imaletsa ntchito yochulukirapo ya mast cell ndi ma cell a glial ndikubwezeretsa ntchito yawo yanthawi zonse.Mwa njira, Palmitoylethanolamide imachepetsanso ntchito ya puloteni yotupa COX.Pali njira zambiri zowonetsera momwe palmitoylethanolamide imagwirira ntchito (yolembedwa m'munsimu patsamba lino.)
Ubwino wa Palmitoylethanolamide
Zakudya zowonjezera zakudya za Palmitoylethanolamide sizinayesedwe ndi Food and Drug Administration, ndipo sizinapangidwe kuti zizindikire, kuchiza, kuchiza kapena kupewa matenda aliwonse.Komabe, mitundu yambiri ya mankhwala a palmitoylethanolamide amakhulupirira kuti idapangidwa kuti izindikire ndikuchiza zowawa zotsutsana ndi zotupa pazamankhwala omwe akuwakayikira, monga ululu wa neuropathic.
- PEA ya Neuropathic Pain
Pachiyeso chimodzi chofunika kwambiri, chosawona kawiri, choyendetsedwa ndi placebo mwa odwala 636 opweteka a sciatic, kupweteka kwakukulu kumachepetsedwa kwambiri ndi 50% pambuyo pa masabata a 3 a chithandizo.
Palibe kuyanjana kwamankhwala kapena zovuta zoyipa zomwe zafotokozedwa pano.
- PEA ndi cholinga choletsa kutupa
Kutupa kumatanthauza kupweteka.Njira yotupa ndiyofunikira kwambiri pakukula kwa Neuropathic Pain.
Palmitoylethanolamide ndi anti-inflammatory and pro-resolving lipid mkhalapakati yemwe amaletsa kuyambitsa kwa mast cell ndikuwongolera machitidwe a cell a glial.Kusalinganika kosalekeza pakati pa oyimira pakati pa pro-inflammatory ndi pro-resolving akuwonetsa kuti neuroinflammation yosatha ikuchitika.
