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High Quality 5000FU/G – 20000FU/G Nattokinase powder

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  • Appearance: Yellow white-off white Powder
  • Standard: GMP, Kosher, HALAL, ISO9001, HACCP
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    Products Description

    Nattokinase Extract is an enzyme extracted and purified from a Japanese food called Natto. Natto is a food made from fermented soybeans that has been eaten in Japan for many years. Natto is produced by fermentation by adding the bacterium Bacillus natto, a beneficial bacteria, to boiled soybeans. The resulting nattokinase enzyme is produced when the bacterium acts on the soybeans. While other soy foods contain enzymes, it is only the natto preparation that contains the specific nattokinase enzyme.

    Enzymatic Properties

    The enzyme is stable in a pH range from 6.0 to 10.0 with the optimum between 7.0 to 9.0. The optimum temperature is 50ºC with a sharp drop over 60ºC.

    Activity

    One (1) FU unit is defined as the amount of the enzyme which increases the absorbency of the filtrate at 275 nm by 0.01 per minute under the conditions of the assay (JBSL). The acceptance criteria for all enzyme assays is: NLT 85.0% and NMT 115.0% of the declared units of enzyme activity.*

    Function & Application

    Nattokinase (NK for short), also known as subtilisin, is a serine protease produced by Bacillus subtilisl natto during the fermentation of natto. It has the functions of dissolving thrombus, reducing blood viscosity, improving blood circulation, softening and increasing blood vessel elasticity.

     A significant function of nattokinase is to dissolve thrombus. Mimugu F et al. used the clot lysis analysis method to determine the fibrinolytic activity of nattokinase, and compared it with Plasmin, and found that the fibrinolytic activity of nattokinase was 4 times that of Plasmin; MiLsugu. F. When nattokinase was injected intravenously into a chemically induced thrombosis model, it was found that there was obvious thrombolysis, and it showed a higher fibrinolytic ability than plasmin and elastase. The above studies indicate that nattokinase exhibits strong fibrinolytic activity both in vitro and in vivo. Nattokinase can also activate plasminogen in the body, thereby increasing the amount of endogenous plasmin. in addition. After oral administration of nattokinase in healthy people, the following effects appear:
    • Obviously shorten the dissolution time (ELT) of euglobulin;
    • Increased fibrinolytic activity in plasma;
    • The amount of t-PA in plasma has increased. Due to NK's safety, stability and good thrombolytic effect, it may be used as an oral agent for thrombosis treatment.

    Basic Analysis

    Analysis Description Test Method
    Activity NLT20000FU/G UV
    Identity Nattokinase FTIR
    Moisture NMT 10% Ohaus MB-45
    Arsenic (As) < 2 ppm ICP-MS/AOAC 993.14
    Cadmium (Cd) < 2 ppm ICP-MS/AOAC 993.14
    Lead (Pb) < 2 ppm ICP-MS/AOAC 993.14
    Mercury (Hg) < 0.5 ppm ICP-MS/AOAC 993.14
    Microbial Analysis
    TPC <10,000 CFU/g Soleris / AOAC 990.12
    E.coli Negative/10g Soleris / AOAC 991.14
    Entero <100 CFU/g AOAC 2003.01
    Salmonella Negative/25g BAM Ch. 5 / AOAC 2011.03
    Yeast <1,000 CFU/g Soleris / AOAC 997.02
    Mold <1,000 CFU/g Soleris / AOAC 997.02
    Coliforms <100 CFU/g Soleris / AOAC 991.14

    Gmo statement

    We hereby declare that, to the best of our knowledge, this product was not produced from or with GMO plant material.

    Ingredient statement

    Statement Option #1: Pure Single Ingredient
    This 100% single ingredient does not contain or use any additives, preservatives, carriers and/or processing aids in its manufacturing process.
    Statement Option #2: Multiple Ingredients
    Must include all/any additional sub ingredients contained in and/or used in its manufacturing process.

    Gluten free statement

    We hereby declare that, to the best of our knowledge, this product is gluten-free and was not manufactured with any ingredients containing gluten.

    (Bse)/ (Tse) Statement

    We hereby confirm that, to the best of our knowledge, this product is free of BSE/TSE.

    Cruelty-free statement

    We hereby declare that, to the best of our knowledge, this product has not been tested on animals.

    Kosher statement

    We hereby confirm that this product has been certified to Kosher standards.

    Vegan Statement

    We hereby confirm that this product has been certified to Vegan standards.

    Food Allergen Information

    ALLERGENS PRESENCE ABSENCE PROCESS COMMENT
    Milk or milk derivatives No Yes No
    Egg or egg derivatives No Yes No
    Fish or fish derivatives No Yes No
    Shellfish, crustaceans, mollusks & their derivatives No Yes No
    Peanuts or peanut derivatives No Yes No
    Tree nuts or their derivatives No Yes No
    Soy or soy derivatives No Yes No
    Wheat or wheat derivatives No Yes No

    Trans Fat

    This product does not contain any trans fats.

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